The defending champion Ohio State Buckeyes look to extend their 12-game winning streak when they visit Purdue, which has dropped 15 straight Big Ten contests.
Ohio State is 7-0-1 against the spread this season, though the Boilermakers have shown more competitiveness in recent weeks.
Find out who I like in my Ohio State vs. Purdue predictions and college football picks for Saturday, November 8.
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Ohio State vs Purdue prediction
Ohio State vs Purdue best bet: Julian Sayin Under 2.5 passing touchdowns (+132)
Julian Sayin is having an incredible debut season as the Ohio State Buckeyes quarterback and is now the favorite to win the Heisman trophy. He now has 23 passing touchdowns on the season to only three interceptions.
However, as bad as the Purdue Boilermakers have been with 15 straight losses in conference play, they've been surprisingly good at keeping opposing passes out of the endzone. Not a single opposing quarterback has thrown for more than two touchdown passes in a game this season.
As good as Sayin has been this season, he does have three games with two or fewer passing touchdowns. This game is also likely to be a blowout, and if Sayin doesn’t get his passing touchdowns early, there will be no reason for him to throw late.
The Boilermakers have given up most of their points through the ground game and turnovers. I believe this game script will lead to fewer passing opportunities for Sayin, and we're getting very good odds on him to do something the Boilermakers have forced in every game this season.
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Ohio State vs Purdue same-game parlay
To add to my best bet, I'm going to add both Buckeyes running backs to make plays; Bo Jackson to get the yards, and CJ Donaldson to find paydirt.
Ohio State vs Purdue SGP
- Julian Sayin Under 2.5 passing touchdowns
- Bo Jackson Over 70.5 rushing yards
- CJ Donaldson anytime touchdown
Our deep-ball SGP: Bang for your Buckeye!
Jeremiah Smith has been racking up the catches and yards this season, and he'll do so again this weekend against Purdue.
Ohio State vs Purdue SGP
- Julian Sayin Under 2.5 passing touchdowns
- Bo Jackson Over 70.5 rushing yards
- CJ Donaldson anytime touchdown
- Jeremiah Smith Over 85.5 receiving yards
Ohio State vs Purdue game predictions
Ohio State vs Purdue moneyline prediction
Ohio State is a 29.5-point favorite for a reason. The Buckeyes will cruise and stay undefeated.
Ohio State vs Purdue spread prediction
Even though the Buckeyes are perfect against the spread this season, I like the points with Purdue.
Ohio State vs Purdue Over/Under prediction
Most of the money is on the Under, moving the total from 49.5 to 48.5.
Ohio State vs Purdue odds
- Spread: Ohio State -29.5 | Purdue +29.5
- Moneyline: Ohio State -10000 | Purdue +2500
- Over/Under: Over 48.5 | Under 48.5
Ohio State vs Purdue trend to know
Purdue has cashed the Under in nine of its last 13 games. Find more college football betting trends for Ohio State vs Purdue.
How to watch Ohio State vs Purdue
| Location | Ross-Ade Stadium, West Lafayette, IN |
| Date | Saturday, November 8, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | BTN |
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Ohio State vs Purdue weather
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Odds are correct at the time of publishing and are subject to change.
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