The noon slate for this week's college football schedule is highlighted by a massive Big 12 showdown between No. 8 BYU and No. 9 Texas Tech, plus a Big Ten matchup that looked much better a month ago as Penn State hosts Indiana.
Covers' college football experts have a best bet for both of those games and more — read on for our college football picks and analysis!
College football best bets for Week 11 early games
| Game | Time (ET) Network |
Best bet |
|---|---|---|
 vs  |
12:00 | ABC | 1H -6.5 -105 |
 vs  |
12:00 | FOX | -14.5 -110 |
 vs  |
12:00 | ESPN | Bowens o43.5 rush -114 |
 vs  |
12:00 | TNT | Over 53.5 -110 |
 vs  |
12:00 | BTN | Sayin u2.5 pass TD +132 |
 vs  |
12:00 | ACCN | Under 55 -115 |
 vs  |
12:00 | ESPN2 | Over 55 -110 |
 vs  |
12:00 | ESPNU | -4.5 -106 |
 vs  |
1:00 | ESPN+ | -2 -110 |
CFB Week 11 preview with Andrew Caley and Douglas Farmer
College Football Week 11 LIVE stream with Douglas Farmer and @Covers_Caley https://t.co/x31udYVjYD
— Douglas Farmer (@D_Farmer) November 5, 2025
BYU vs Texas Tech best bet
Texas Tech 1H -6.5 (-105 at FanDuel)
With Behren Morton, the Red Raiders have covered the first-half spread in three of their four games against Power Four foes, the kind of early emphasis that will protect against late-game stresses if BYU is mounting an otherwise meaningless drive.
See our full analysis and Cougars/Red Raiders SGP in our BYU vs. Texas Tech predictions.
Indiana vs Penn State best bet
Indiana -14.5 (-110 at FanDuel)
There is no blueprint for success the Nittany Lions can follow to get a win — and once the Hoosiers force them to abandon the run, the game will get out of hand as Indiana wins by at least three scores.
See our full analysis and Hoosiers/Nittany Lions SGP in our Indiana vs. Penn State predictions.
Georgia vs Mississippi State best bet
Chauncey Bowens Over 43.5 rushing yards (-114 at FanDuel)
Bowens' production and volume are trending up, and now he draws a Mississippi State defense that has recently been a sieve against the run. A likely game script with Georgia leading throughout should create even more rushing volume as well, making it my second two-unit play of the season.
See our full analysis and all-Bulldogs SGP in our Georgia vs. Mississippi State predictions.
Colorado vs West Virginia best bet
Over 53.5 (-110 at FanDuel)
This game between Colorado and West Virginia should be pure chaos; two defenses that can’t stop explosive plays, two quarterbacks who’ll either light it up or throw it straight to the other team, and coaching that could make a Pop Warner dad blush.
See our full analysis and Buffaloes/Mountaineers SGP in our Colorado vs. West Virginia predictions.
Ohio State vs Purdue best bet
Julian Sayin Under 2.5 passing touchdowns (+132 at FanDuel)
As bad as Purdue has been in conference play, not a single opposing quarterback has thrown for more than two touchdown passes in a game this season. This game is also likely to be a blowout, and if Sayin doesn’t get his passing touchdowns early, there will be no reason for him to throw late.
See our full analysis and Buckeyes/Boilermakers SGP in our Ohio State vs. Purdue predictions.
SMU vs Boston College best bet
Under 55 (-115 at FanDuel)
Boston College ranks 12th-worst in the country in converting quality drives into points, sitting in the Bottom 20 in both rushing EPA and passing EPA. There is nothing encouraging about this offense, and it has actually gotten worse as the season has gone along. Plus, SMU has cashed six Unders in its last seven games... and its offense has fallen off in the last two weeks.
See full analysis, and more of Douglas' best bets for Week 11, in his college football predictions for Week 11.
James Madison vs Marshall best bet
Over 55 (-110 at FanDuel)
Marshall has had each of its last five games go Over the total... by an average of 22 points per game! JMU is in the mix for the Sun Belt title and has kept its foot on the pedal here in the second half of the season, and they'll do it again here.
See more picks and our college football Week 11 breakdown on the Covers YouTube channel.
Southern Miss vs Arkansas State best bet
Southern Miss -4.5 (-106 at FanDuel)
Looking at the most widely accepted college football metric, ESPN.com’s SP+ ratings, Southern Miss would be a nine-point favorite on a neutral field. Is Centennial Bank Stadium in Jonesboro really worth more than two points... let alone the 4.5 reflected by this spread?
See full analysis, and more of Douglas' best bets for Week 11, in his college football predictions for Week 11.
Bowling Green vs Eastern Michigan best bet
Eastern Michigan -2 (-110 at FanDuel)
Eastern Michigan is coming off a bye and Bowling Green has failed to cover the spread by more than three touchdowns per game on average.
See more picks and our college football Week 11 breakdown on the Covers YouTube channel.
Odds are correct at the time of publishing and are subject to change.
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