Fresh off a statement win over Purdue, the Ohio State Buckeyes shift their focus to a road clash with the Penn State Nittany Lions.
Both teams could be vulnerable to a letdown tonight, but my Ohio State vs. Penn State predictions are fading the Nittany Lions on their home floor.
Here are my best free college basketball picks for this Big Ten clash on Wednesday, March 4.
Ohio State vs Penn State prediction
Ohio State vs Penn State best bet: Ohio State -7 (-110)
Penn State ranks 233rd nationally in adjusted defensive efficiency — the worst mark of any high-major program.
On the other end, things haven’t been much better. Since the start of February, the Nittany Lions are shooting just 29.6% from beyond the arc and sit 16th in the conference in turnover rate.
Ohio State already handled PSU 84-78 back in January and did so without center Christoph Tilly in the lineup. Penn State also knocked down 40% of its threes in that matchup — a number that is due for some regression tonight.
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Ohio State vs Penn State same-game parlay
OSU sharpshooter John Mobley Jr. poured in 25 points and buried five triples in the first meeting with Penn State. He'll torch a Nittany Lions squad that ranks 348th in the country in threes allowed per game (9.7).
Meanwhile, Buckeyes forward Amare Bynum has eclipsed 4.5 rebounds in four of his previous five games. He also snagged five rebounds in the previous meeting with PSU.
Ohio State vs Penn State SGP
- Ohio State -7
- John Mobley Over 15.5 points
- Amare Bynum Over 4.5 rebounds
Our beyond the arc SGP: Buckeyes Blowout
Since we're betting on OSU to cover due to Penn State's atrocious defense, let's also back star point guard Bruce Thornton (20.0 ppg, 3.7 apg) to eclipse his assists total.
Ohio State vs Penn State SGP
- Ohio State -7
- John Mobley Over 15.5 points
- Amare Bynum Over 4.5 rebounds
- Bruce Thornton Over 4.5 assists
Ohio State vs Penn State odds
- Spread: Ohio State -7 (-110) | Penn State +7 (-110)
- Moneyline: Ohio State -315 | Penn State +255
- Over/Under: Over 153 (-110) | Under 153 (-110)
Ohio State vs Penn State betting trend to know
The Buckeyes have covered the first-half spread in 10 of their last 15 games (+4.30 Units / 25% ROI). Find more college basketball betting trends for Ohio State vs. Penn State.
How to watch Ohio State vs Penn State
| Location | Bryce Jordan Center, University Park, PA |
| Date | Wednesday, March 4, 2026 |
| Tip-off | 7:30 p.m. ET |
| TV | Peacock |
Ohio State vs Penn State key injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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