The San Francisco Giants and San Diego Padres continue their three-game set tonight with two offenses still searching for consistency, which puts even more weight on the starting pitching matchup.
That’s good news for San Francisco.
With Logan Webb taking the ball against a Padres lineup that’s struggled to generate offense lately, my Giants vs. Padres predictions and MLB picks are backing the home side to take advantage in a low-scoring battle on Tuesday, May 5.
Who will win Padres vs Giants today: Giants ML (-127)
Logan Webb is the biggest reason to trust San Francisco here. The veteran right-hander has consistently handled the San Diego Padres well, including a win in his last outing against them, and this version of San Diego’s lineup looks far less threatening than in years past.
The Padres have struggled to string together quality at-bats lately, scoring just four runs in five May contests, especially against pitchers who can limit hard contact and work deep into games — two things Webb does extremely well.
With both offenses trending toward low-scoring performances, this game likely comes down to which starter gives his team the cleaner innings. Right now, that edge belongs to Webb and the Giants at a reasonable price.
COVERS INTEL: Logan Webb struck out five Padres in his first start this season, picking up the win after six solid innings of work. 
Padres vs Giants Over/Under pick: Under 7.5 (-115)
This matchup checks almost every box for a low-scoring game. San Diego enters averaging just 3.1 runs per game, dead last in home runs, while San Francisco’s offense hasn’t exactly inspired confidence either. Both teams sit near the bottom of the league in OPS and slugging percentage, making sustained rallies difficult to trust.
On the mound, Logan Webb gives the Giants a reliable edge in a game that already projects to be tight. Even Walker Buehler’s underlying matchup is manageable against a San Francisco lineup lacking consistent power production.
Unless defensive mistakes or bullpen implosions take over late, this feels more like a 3-2 or 4-2 type of game.
Padres vs Giants odds
- Moneyline: Padres +110 | Giants -130
- Run line: Padres +1.5 (-190) | Giants (-1.5 (+160)
- Over/Under: Over 7.5 | Under 7.5
Padres vs Giants trend
The Giants have played to the Under in six of their last seven games. Find more MLB betting trends for Padres vs. Giants.
How to watch Padres vs Giants and game info
| Location | Oracle Park, San Francisco, CA |
| Date | Tuesday, May 5, 2026 |
| First pitch | 9:45 p.m. ET |
| TV | Padres.TV, NBCSBA |
| Padres starting pitcher | Walker Buehler (1-2, 4.50 ERA) |
| Giants starting pitcher | Logan Webb (2-3, 4.30 ERA) |
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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