White Sox vs Guardians Best Bets, Expert Picks & ALDS Game 5 Predictions Tonight

Robert Criscola - Betting Analyst at Covers.com
Robert Criscola • Betting Analyst 11+ years betting experience
Updated: Oct 10, 2026 , 12:16 PM ET • 4 min read

Get the top picks from our MLB experts for tonight's do-or-die Game 5 of the ALDS between the White Sox and the Guardians, featuring Miguel Vargas.

Chicago White Sox Miguel Vargas MLB
Photo By - Reuters Connect. Chicago White Sox third baseman Miguel Vargas (20) celebrates after hitting a home run.

Our White Sox vs. Guardians expert picks for Game 5 are all over the place!

We've got one expert on each side of the fence in this win-or-go-home affair, plus a White Sox vs. Guardians props play to consider.

Don't miss our White Sox vs. Guardians predictions for Saturday, Oct. 10.

White Sox vs Guardians expert picks for Game 5

Pick Probability
Dustin Saracini Dustin Saracini: Vargas 2+ hits + runs + RBI 46%
Todd Cordell Todd Cordell: CHW ML 44%
Quinn Allen Quinn Allen: CLE ML 57%

Probabilities courtesy of Polymarket. For help understanding Polymarket probabilities, see our odds calculator.

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Dustin Saracini's expert pick: Miguel Vargas 2+ hits + runs + RBI

Price: 46¢ at Polymarket

Miguel Vargas was one of the most productive hitters in the White Sox lineup all season, and now we're getting him at this price in an elimination game against a pitcher he's historically crushed? Sign me up.

Vargas is 7-for-15 against Gavin Williams (.295 xBA, .548 xSLG) with a home run to his name. He's cashed this prop in three of four games this series, giving me the confidence I need to hit the button.

Todd Cordell's expert pick: White Sox moneyline

Price: 44¢ at Polymarket

I like the Chicago White Sox to take Game 5 and advance to the next round.

The Cleveland Guardians have not shown much life at the plate in this series. They have hit just .214 with a putrid xBA of .164 and xwOBA of .251.

Very rarely are they making elite contact, generating just two barrels over 102 batted ball events.

Gavin Williams will give the Guardians a fighting chance, but his feast-or-famine approach (elite K%, putrid hard-hit rate) will likely lead to some damage against a White Sox team that finished fifth in home runs.

Quinn Allen's expert pick: Guardians moneyline

Price: 57¢ at Polymarket

I'm backing the Guardians tonight behind Gavin Williams. He's been lights-out in this series, posting a 0.60 FIP while not allowing a single barrel.

Cleveland also draws a favorable matchup against Sean Burke, who's already surrendered three home runs this postseason with a 47.8% hard-hit rate.

This could still be a tight Game 5, but with Williams suppressing quality contact and Burke giving up plenty of it, Cleveland owns the more trustworthy pitching matchup.

How to watch White Sox vs Guardians

Location Progressive Field, Cleveland, OH
Date Saturday, Oct. 10, 2026
Kickoff 8 p.m. ET
TV TBS

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Robert Criscola - Covers.com
Betting Analyst

Robert M. Criscola’s road to becoming a Covers publishing editor began with an internship at Metro New York, which eventually turned into a freelance job at MetroBet covering many sports from a wagering angle, including horse racing. He continued to focus on “The Sport of Kings” by writing for shapperdacapper.com, danonymousracing.com, and informer.fanxt.com before joining the team at the TwinSpires Edge in 2019 as a regular contributor and weekend editor. “Crisco” began writing game previews for Covers in 2022 and joined the editing team in 2023.

His best advice for sports bettors? Bet with your head, not over it.

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