Cubs vs Cardinals Prediction, Picks & Odds for Today’s MLB Game

Cardinals SP Michael McGreevy is not overpowering, as the rookie right-hander primarily pitches to contact. That bodes poorly against the lefty-heavy Cubs, who will ride Michael Busch and Pete Crow-Armstrong to victory.

Neil Parker - Analyst at Covers.com
Neil Parker • Betting Analyst
Jun 24, 2025 • 11:05 ET • 4 min read

MLB

Match starts: 3 hrs
STL
45 %
CHC
55 %
EXPERT PICK - MONEYLINE
Chi. Cubs -109 Chi. Cubs -109
Read Analysis
Pete Crow-Armstrong Chicago Cubs MLB
Photo By - Imagn Images. Pete Crow-Armstrong reacts after hitting a home run.

The St. Louis Cardinals took the series opener against the Chicago Cubs, and the division rivals will hit Busch Stadium for Game 2 on Tuesday, June 24.

My top Cubs vs. Cardinals predictions and MLB picks anticipate that the Chicago bats will lead the way to victory.

Cubs vs Cardinals prediction

My Cubs vs Cardinals best bet: Cubs moneyline (-109 at Pinnacle)

Cubs vs Cardinals same-game parlay (SGP)

Cubs -1.5

Michael Busch Over 1.5 hits + runs + RBI

Pete Crow-Armstrong Over 1.5 hits + runs + RBI

Cubs vs Cardinals odds

Cubs vs Cardinals live odds

Cubs vs Cardinals opening odds

  • Moneyline: Chicago -120 | St. Louis +100
  • Run line: Chicago -1.5 (+140) | St. Louis +1.5 (-168)
  • Over/Under: Over 9 (-110) | Under 9 (-110)

Cubs vs Cardinals trend

The Chicago Cubs have hit the moneyline in 42 of their last 70 games (+8.05 Units / 8% ROI). Find more MLB betting trends for Cubs vs. Cardinals.

How to watch Cubs vs Cardinals and game info

Location Busch Stadium, St. Louis, MO
Date Tuesday, 6-24-2025
First pitch 7:45 p.m. ET
TV Marquee, FDSNMW
Cubs starting pitcher Jameson Taillon
(7-4, 3.84 ERA)
Cardinals starting pitcher Michael McGreevy
(1-1, 2.70 ERA)

Cubs vs Cardinals latest injuries

Cubs vs Cardinals weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Neil Parker - Covers
Betting Analyst

Neil Parker is, first and foremost, a sports fan. A huge supporter of the Cowboys, Cubs, and Maple Leafs, he has managed to parlay his passion into writing gigs with Sportsbook Review, USA TODAY, theScore, DraftKings Playbook, and RotoWire, among many others. He also co-hosted the Daily Fantasy Edge podcast and can now be seen offering expert golf and hockey advice on Covers’ Before you Bet broadcast.

Neil takes a numbers-based approach to his handicapping and complements his in-depth statistical analysis with a keen eye on the markets to provide the best available odds. He loves to lean on his rolodex of idioms to offset his inner nerd. When it comes to wagering, he throws down on anything that catches his eye at bet365, Betway and BetVictor. He also keeps a close eye on CoolBet because the polar bear brand often has outlier NHL and NFL moneyline prices.

Neil graduated with honors from St. Thomas University in 2007 before completing his BEd at Acadia University in 2010. After teaching a myriad of courses and subjects, he found a groove delivering fun lessons to exceptional learners in non-traditional classroom environments. If his decade-plus teaching run taught him anything about sports betting, it’s to stay the course and use the summer – or offseason – to refresh and prepare to be better in the year to come.

Neil’s top pieces of advice for recreational bettors are to stay within your means and to remember sportsbooks aren’t bank accounts. Don’t be afraid to pull those winnings and treat yourself to a lifetime experience courtesy of a big win.

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