The Crimson Tide have lost two of the last three Iron Bowls, as 3.5 and 6-point favorites. Oddsmakers don't expect them to falter this year, as they are more than three-touchdown chalk.
Oregon State RB Jermar Jefferson is averaging 7.2 yards per carry this season and gets to face an Oregon defense that was just gashed by UCLA for 267 rushing yards.
Spencer Rattler and the Sooners offense is hitting its stride right now, as the QB is coming off a four-touchdown performance in a 41-13 pasting of rival Oklahoma State.
The Colorado Buffaloes are off to a 2-0 start in the Pac-12 this season, led by QB Sam Noyer, who's thrown for 512 yards and three touchdowns.
With QB Spencer Sanders questionable to play Saturday, the Oklahoma State Cowboys will likely lean on their running game when Texas Tech comes to visit Stillwater.
Grad transfer QB Nick Starkel has been a key factor in San Jose State's turnaround this season, completing almost 71 percent of his passes for 980 yards for the 4-0 Spartans.
Both Stanford and Cal are 0-2 heading into their Thanksgiving rivalry matchup, but with an extra week to prepare, do the Cardinal have the advantage over the Golden Bears?
Quarterback Brock Purdy has helped put Iowa State in contention for its first-ever Big 12 championship. FanDuel Sportsbook opened the Cyclones 2.5-point underdogs at Texas.
Dillon Gabriel has thrown for 3,017 yards with 26 touchdowns and just three interceptions this season, guiding a UCF passing attack that is ranked first in the nation.
As COVID-19 continues to wreak havoc on the NCAA football season, Kyle Trask has wreaked havoc on opposing defenses, and now sits as the odds-on Heisman favorite (-134).
Ian Book led the Fighting Irish in not only passing but rushing in their win over Boston College, continuing the heroics that have him remaining a dark-horse Heisman candidate.
Mekhi Sargent is a dangerous cog in the run game that has helped propel Iowa to an average of 41.7 points over its last three games.
Iowa State's stop unit is quietly ranked in the Top 40 nationally in total defense, which could pose a problem for a Texas offense that has some overinflated numbers.
With a perfect record, including three dominant wins over ranked teams, plus the highest-scoring offense in the nation, Alabama remains the betting favorite to win the 2021 National Championship.
Wideout Whop Philyor and No. 10 Indiana hope their surprising season continues Saturday at No. 3 Ohio State. But oddsmakers aren't seeing it, as the Buckeyes are 20.5-point favorites in the Big Ten clash.
The Kentucky defense ranks 40th in total defense and is giving up just 21.3 and 214.1 passing yards per game. But they haven't faced an offense to the level of Mac Jones and the Crimson Tide.
CJ Verdell and Travis Dye join forces with QB Tyler Shough to form a three-headed monster that's spearheading Oregon's run game to 269 yards in each of their first two games.
The Ducks have rumbled for 269 rushing yards in each of their first two games. They take on a UCLA squad that has faced its share of difficulties on offense so far.
Tennessee gives up the fourth-most rushing yards per game in the SEC, which means a big day should be in order for Auburn RB Tank Bigsby, who averages nearly six yards per carry.
Freshman QB Graham Mertz has brought balance to the Wisconsin Badgers offense, which perfectly complements one of the nation's stingiest defenses.