San Francisco @ Buffalo Game Overview

Buffalo (9-2) has won six straight games and is on the verge of a fifth consecutive AFC East crown. The Miami Dolphins (5-7) dropped a 30-17 decision to the Green Bay Packers on Thursday, a result that allows the Bills the chance to wrap up the division title with a win on Sunday.

Buffalo will be up against a San Francisco squad that may not have quarterback Brock Purdy for a second straight week.

Purdy was a limited practice participant on Wednesday and Thursday with the majority of his workload consisting of handoffs due to his ailing right shoulder. A full participant on Friday, Purdy is officially questionable for the game.

The 49ers (5-6) have lost back-to-back games entering a pivotal contest.

Buffalo had a bye last week following an impressive 30-21 home victory over the Kansas City Chiefs.

"To be at the bye week ... at 9-2 and obviously feeling confident about what we got going on here and the guys that we have in this locker room, it's a great feeling," Bills quarterback Josh Allen said.

Allen said it's too early to assume a playoff spot, while Buffalo cornerback Taron Johnson wants to prevent a letdown.

"I love where we're at, but at the same time, we just got to make sure that that we keep that same fire and not get complacent and just continue to play our best ball moving forward," Johnson said. "So even though we have a good record, we still have things we have to clean up and things we got to get better at."

Buffalo has scored at least 30 points in five consecutive games. Allen has passed for 18 touchdowns against five interceptions this season after throwing a career-worst 18 picks last season.

San Francisco got walloped last week without Purdy, falling 38-10 to the host Packers. Brandon Allen started at quarterback and completed 17 of 29 passes for 199 yards with one touchdown pass, one interception and one lost fumble.

Allen is 2-8 as an NFL starter. He received heavy work in practice in case Purdy's shoulder doesn't significantly improve.

The 49ers could use a big performance from running back Christian McCaffrey, who had just 31 yards on 11 carries and caught three passes for 37 yards against Green Bay.

McCaffrey missed the first eight games of the season with an Achilles tendon injury and has struggled to run the ball in his three appearances. He has 149 yards on 43 rushes for a paltry 3.5-yard average.

"When you lose and maybe you don't jump out on the stat sheet, your failures are highlighted," McCaffrey said Wednesday. "I'm happy I'm out here playing football and I just know with time it will come."

San Francisco tight end George Kittle had six receptions against the Packers to move into third place on the club's all-time list with 509 receptions. He passed franchise legends Dwight Clark (506) and Roger Craig (508).

Star defensive end Nick Bosa (hip, oblique) and left tackle Trent Williams (ankle) will sit out again. Both players missed the game against Green Bay. The Niners will also be without guard Aaron Banks (concussion), defensive tackle Jordan Elliott (concussion) and cornerback Deommodore Lenoir (knee).

Linebacker Dre Greenlaw, who tore his left Achilles tendon during last season's Super Bowl, was back at practice as a limited participant this week but will not play against Buffalo.

Star linebacker Fred Warner wasn't listed on San Francisco's injury report but said he fractured a bone in his ankle on Sept. 29 against the New England Patriots and has been playing through the injury.

"I get on that table before every game and get it shot up every single game just to be able to roll," Warner said. "But it's not an excuse. It's just what it is. That's the NFL."

Bills tight end Dalton Kincaid (knee) was ruled out for the contest. Linebacker Matt Milano (biceps) was a full participant at practice all week and could be activated from injured reserve for the contest. He is listed as questionable. Milano was hurt during the preseason.

Wide receiver Keon Coleman (wrist) and defensive tackle DeWayne Carter (wrist) are also questionable.

Buffalo averaged 39.5 points while winning the last two meetings with the 49ers, in 2016 and 2020.

--Field Level Media