NFL Week 5 Picks: ChatGPT Predicts the Winner of Every Game

Week 5 is here and the NFL dial just got turned up to MAX.

Contenders are separating, upstarts are swaggering, and every snap feels like a season tipping point. We’ve got revenge games, unbeaten streaks, and prime-time chaos queued up under the bright lights.

Instead of leaving the picks to the talking heads, we've turned to artificial intelligence. Using the Week 5 moneyline odds from FanDuel, we asked ChatGPT to pick the straight-up winners of every single game on the schedule from the opening whistle on Thursday night to the final play on Monday.

Here’s how the AI sees Week 5 shaking out with its NFL picks. 

Week 5 NFL moneyline picks

Matchup	Pick
49ers vs  Rams	-480
Vikings vs  Browns	+160
Cowboys vs  Jets	-142
Broncos vs  Eagles	-198
Texans vs  Ravens	+108
Giants vs  Saints	-124
Raiders vs  Colts	-330
Dolphins vs  Panthers	-116
Buccaneers vs  Seahawks	-180
Titans vs  Cardinals	-430
Commanders vs  Chargers	-158
Lions vs  Bengals	-520
Patriots vs  Bills	-420
Chiefs vs  Jaguars	-178

Lines courtesy of FanDuel.

49ers vs Rams: Rams (-480)

With Brock Purdy ruled out (toe) and Mac Jones starting on a short week, the 49ers’ offense is stretched thin—Jauan Jennings and Ricky Pearsall are also out, while George Kittle (IR) and Brandon Aiyuk remain sidelined—shrinking San Francisco’s passing options and tilting leverage toward a ball-control, field-position game the Rams can script at home.

Vikings vs Browns:  Browns (+160)

Neutral-site mornings reward defenses that win the line of scrimmage and special teams that flip fields. Cleveland’s blueprint—front-four disruption and conservative, mistake-averse offense—fits the London template. Minnesota’s explosive spurts keep them live, but travel quirks and a likely Browns market edge on the moneyline nudge this call toward Cleveland.

Cowboys vs Jets:  Cowboys (-142)

Dallas’ pass rush and early-down efficiency make them a sturdy moneyline choice even in tricky road spots. If the Cowboys force obvious passing downs, they tilt field position and set up short scoring drives. 

Broncos vs Eagles: Eagles (-198)

Lincoln Financial Field is a high-variance place for visitors: crowd energy, physical fronts, and steady situational offense. The Eagles’ ability to own fourth-and-short and red-zone packages boosts straight-up win equity. Denver’s path is turnover-driven; absent that, Philly is the rightful side.

Texans vs Ravens:  Ravens (+108)

In a physical home environment, Baltimore’s ability to compress the red zone and control pace makes them a difficult fade. The Texans have the playmaking to spike, but sustained success outside script is tough at M&T. 

Giants vs Saints:  Saints (-124)

The Saints’ defense usually plays to the dome: noise, communication stress, and disguised coverage looks that punish long-developing plays. Offensively, New Orleans doesn’t need fireworks to win this straight-up—just a clean script and red-zone conversions. The market often backs the Saints at home in these profiles, and I do here, too.

Raiders vs Colts:  Colts (-330)

In games like these, lean to the home team with the sturdier trenches and fewer turnover landmines. Indy’s ability to sustain drives, protect the ball, and generate just enough pressure points to the Colts in a game where one short field could swing it.

Dolphins vs Panthers:  Dolphins (-116)

Speed travels. Miami’s explosive play rate and layered motion stress young secondaries, forcing one-on-one tackles in space. If Miami jumps ahead, the Panthers’ offense faces unfavorable down-and-distance and shorter fields for the Dolphins’ defense. Market position at FanDuel tends to reflect Miami’s higher weekly ceiling, and the spot supports it.

Buccaneers vs Seahawks: Seahawks (-180)

Crowd, travel, and weather angle into Seattle’s home-field advantage, and FanDuel’s board typically prices that in. The Seahawks’ offense doesn’t need to be vertical all afternoon; methodical drives plus a couple of scripted explosives usually suffice. Tampa Bay’s defense keeps this tight, but the straight-up edge leans Seattle at Lumen Field. 

Titans vs Cardinals:  Cardinals (-430)

State Farm Stadium has quietly been kind to Arizona. The Cardinals usually play with tempo and keep early downs on schedule at home; if they do that here, they can avoid predictable passing downs versus a physical Titans front. I give a slight nod to Arizona’s home splits. 

Commanders vs Chargers:  Chargers (-158)

The Chargers’ profile—high early-down success, aggressive fourth-down philosophy—translates to higher straight-up win equity in median game scripts, especially at home. Washington’s path involves explosives and short fields; absent multiple swings, LA’s offense is the more repeatable unit.

Lions vs Bengals:  Lions (-520)

FanDuel lists the Lions at -520 at Cincinnati, aligning with Detroit’s form and Cincinnati’s defensive profile. Jared Goff draws a Bengals pass defense ranked 30th by yards allowed, a favorable spot for Detroit’s play-action and intermediate game. The Lions have won three straight, including a 34-10 rout in Week 4, and head to Paycor for a 4:25 p.m. ET kickoff with a balanced script that travels—efficient early downs, red-zone finishing, and a stout front. Straight up, that’s a high-floor path.

Patriots vs Bills:  Bills (-420)

In prime time at Orchard Park, Buffalo’s blend of quarterback play and pass-rush pressure typically elevates floor and ceiling. On a pure moneyline, the Bills’ turnover margin and explosive-play edge are meaningful edges. New England can shorten the game, but sustained drives are harder on the road here.

Chiefs vs. Jaguars   Chiefs (-178)

The Chiefs’ late-down and two-minute edges remain among the league’s most bankable moneyline advantages, even outdoors on the road. Jacksonville can challenge with speed and creativity, but KC’s ability to win third down, protect the ball, and generate one or two chunk plays tilts the straight-up call.

ChatGPT has gone 48-15 so far this season for +28.6 units.

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