Jaguars 1st AFC South13-4

49ers 3rd NFC West12-5

4:05PM ET Sep 28, 2025

FOX

Jaguars @ 49ers Odds

Game Odds

Game Odds Jacksonville Jaguars vs. San Francisco 49ers
	Spread	Total	Moneyline
Sports.OddsComparison.BettingLines.Models.BettingSide.SpreadBettingSideVm Jacksonville	+5.5 -120	o45.5 -110	+185
Sports.OddsComparison.BettingLines.Models.BettingSide.SpreadBettingSideVm San Francisco	-5.5 -110	u47.5 -120	-165

Spread

Game Odds Jacksonville Jaguars vs. San Francisco 49ers
	JAC	SF
	+5.5 -120	-5.5 -110

Odds Comparison

ALL BOOKS	JAC	SF
DraftKings logo	+5.5 -120	-5.5 -110
bet365 logo	+3.0 -110	-3.0 -110
FanDuel logo	+3.5 -102	-3.5 -130
BetMGM logo	+3.0 -110	-3.0 -110
Caesars logo	+3.0 -112	-3.0 -110

Total

Game Odds vs.
	OVER	UNDER
	o45.5 -110	u47.5 -120

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o47.5 -110	u47.5 -120
bet365 logo	o46.0 -110	u46.0 -110
FanDuel logo	o46.5 -136	u46.5 +102
BetMGM logo	o45.5 -110	u45.5 -110
Caesars logo	o46.0 -112	u46.0 -109

Moneyline

Game Odds Jacksonville Jaguars vs. San Francisco 49ers
	JAC	SF
	+185	-165

Odds Comparison

ALL BOOKS	JAC	SF
DraftKings logo	+185	-245
bet365 logo	+140	-165
FanDuel logo	+172	-225
BetMGM logo	+145	-175
Caesars logo	+140	-176

Passing Yards

Brock Purdy Projection 241.23

Game Odds vs.
OVER	UNDER
o243.5 -113	u246.5 -135

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o243.5 -113	u243.5 -111
bet365 logo	-	-
FanDuel logo	o244.5 -112	u244.5 -112
BetMGM logo	o246.5 +100	u246.5 -135
Caesars logo	o244.5 -117	u244.5 -115

Trevor Lawrence Projection 239.97

Game Odds vs.
OVER	UNDER
o225.5 -113	u231.5 -112

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o225.5 -113	u225.5 -111
bet365 logo	-	-
FanDuel logo	o231.5 -112	u231.5 -112
BetMGM logo	o229.5 -115	u229.5 -115
Caesars logo	o228.5 -115	u228.5 -117

Rushing Yards

Christian McCaffrey Projection 66.28

Game Odds vs.
OVER	UNDER
o71.5 -115	u74.5 -115

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o71.5 -115	u71.5 -109
bet365 logo	-	-
FanDuel logo	o72.5 -112	u72.5 -112
BetMGM logo	o74.5 -115	u74.5 -115
Caesars logo	o72.5 -112	u72.5 -121

Travis Etienne Jr. Projection 53.12

Game Odds vs.
OVER	UNDER
o46.5 -112	u54.5 -135

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o48.5 -111	u48.5 -113
bet365 logo	-	-
FanDuel logo	o46.5 -112	u46.5 -112
BetMGM logo	o54.5 +100	u54.5 -135
Caesars logo	o48.5 +105	u48.5 -138

Brock Purdy Projection 24.8

Game Odds vs.
OVER	UNDER
o10.5 -118	u13.5 -112

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o12.5 -118	u12.5 -107
bet365 logo	-	-
FanDuel logo	o13.5 -112	u13.5 -112
BetMGM logo	o10.5 -118	u10.5 -110
Caesars logo	o12.5 -112	u12.5 -120

Trevor Lawrence Projection 11.38

Game Odds vs.
OVER	UNDER
o9.5 -120	u10.5 -110

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o10.5 -113	u10.5 -111
bet365 logo	-	-
FanDuel logo	o10.5 -112	u10.5 -112
BetMGM logo	o9.5 -120	u9.5 -110
Caesars logo	o10.5 -121	u10.5 -110

Brian Robinson Jr.

Game Odds vs.
OVER	UNDER
o19.5 -112	u22.5 -108

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o22.5 -116	u22.5 -108
bet365 logo	-	-
FanDuel logo	o19.5 -112	u19.5 -112
BetMGM logo	o20.5 -118	u20.5 -110
Caesars logo	o20.5 -112	u20.5 -120

Brian Thomas Jr.

Game Odds vs.
OVER	UNDER
o0.5 +375	u0.5 -600

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	-	-
bet365 logo	-	-
FanDuel logo	-	-
BetMGM logo	o0.5 +375	u0.5 -600
Caesars logo	-	-

Game Odds vs.
OVER	UNDER
o22.5 -111	u23.5 -105

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o22.5 -111	u22.5 -114
bet365 logo	-	-
FanDuel logo	o23.5 -112	u23.5 -112
BetMGM logo	o22.5 -120	u22.5 -110
Caesars logo	o23.5 -128	u23.5 -105

Receiving Yards

Receptions Made

Rushing Attempts

Passing Attempts

Passing Completions

Interceptions Thrown

Rush and Rec Yards

Passing and Rushing Yards

Pages Related to This Topic