Week 10 rolls in like a blitz, so we’re calling an audible. We fed FanDuel’s latest NFL odds into ChatGPT and instructed the large language model to pick straight-up moneyline winners.
The AI bot weighed measurable inputs like recent form, travel and rest, matchup tendencies, and situational performance before determining who will be cashing tickets.
Love it or fade it, the NFL picks are in and the receipts are ready. Fire up the apps, grab the remote, and let’s ride the algorithm all the way to profit!
Week 10 NFL moneyline picks
| Matchup | Pick |
|---|---|
 Raiders vs  Broncos |
-500 |
 Falcons vs  Colts |
-270 |
 Ravens vs  Vikings |
-220 |
 Patriots vs  Buccaneers |
-142 |
 Jaguars vs  Texans |
-104 |
 Browns vs  Jets |
+108 |
 Saints vs  Panthers |
-250 |
 Giants vs  Bears |
-190 |
 Bills vs  Dolphins |
-510 |
 Cardinals vs  Seahawks |
-310 |
 Rams vs  49ers |
-205 |
 Lions vs  Commanders |
-500 |
 Steelers vs  Chargers |
-154 |
 Eagles vs  Packers |
+118 |
Lines courtesy of FanDuel.
Raiders vs Broncos: Broncos (-500)
Denver’s defense has been carrying form, and the altitude edge on a short week matters against a travel-weary opponent. With the Broncos priced as the favorite on FanDuel and hosting in prime time, the path to a straight-up win runs through limiting early negative plays and leaning on field position.
Read our full Raiders vs. Broncos predictions.
Falcons vs Colts: Colts (-270)
FanDuel lists Indianapolis as the favored side for this neutral-window kickoff in Berlin, and its offensive balance is the cleaner profile if this turns into a possession game. Atlanta’s best chance is a ball-control script, but Indy’s red-zone finishing has tracked better of late. We’re backing the favorite on the moneyline.
Ravens vs Vikings: Ravens (-220)
Market support has tilted toward Baltimore this week, with FanDuel showing the Ravens favored on the road. Baltimore’s pass rush vs. a Vikings front that can be volatile tips the straight-up call, and the Ravens’ late-down efficiency travels.
Patriots vs Buccaneers: Buccaneers (-142)
At home, Tampa Bay carries favorite status at FanDuel and the better turnover differential trend. The Bucs’ ability to win field position and avoid self-inflicted errors should be enough in a lower-variance. We’re keeping it simple and backing the home favorite.
Jaguars vs Texans: Texans (-104)
Houston’s offense has earned consistent market respect, and FanDuel has the Texans favored at home. In a matchup likely decided by red-zone finishing, we’ll side with the steadier passing operation in its own building.
Browns vs Jets: Jets (+108)
A defensive-tilt profile makes variance king, but special-teams edges nudges this into a modest ML lean toward New York. Expect a field-position slog where the home crowd and short fields matter.
Saints vs Panthers: Panthers (-250)
Carolina deserves the -250 moneyline tag because its formula is built for a low-variance result at home: a run-first script behind an improving line, efficient early-down sequencing, and a defense that limits explosives and wins field position.
Against a Saints offense that has struggled to finish drives and protect in obvious passing downs, the Panthers can control pace, shorten the game, and leverage favorable field position. Special teams have been steady, and home noise amplifies pass-rush timing. Carolina projects as the steadier side to close out a one-score script late.
Giants vs Bears: Bears (-190)
With Chicago the favorite at Soldier Field, this sets up as a trenches game where the Bears’ run game and QB mobility are useful levers. In a straight-up market, home-field plus slightly better late-down metrics decide the lean.
Bills vs Dolphins: Bills (-510)
FanDuel has Buffalo as a substantial favorite, and the matchup history has leaned heavily their way. If the Bills protect the ball, their down-to-down success rate should carry. Miami’s best path is explosives, but the moneyline call is Buffalo.
Cardinals vs Seahawks: Seahawks (-310)
Seattle is the prohibitive moneyline favorite at home, and the matchup leans toward the Seahawks’ pass rush and crowd noise dictating Arizona’s cadence and protection. In a straight-up context, Seattle’s floor is simply higher.
Rams vs 49ers: Rams (-205)
The Rams are rightful moneyline favorites at -205 because their offense has been humming and travel-friendly: Matthew Stafford is pushing the ball efficiently off play-action, and Los Angeles has finished drives with touchdowns in recent weeks. Protection has held up, letting quick-game and deep shots coexist, while Puka Nacua’s availability restores spacing and third-down reliability.
Sean McVay’s scripted starts often create an early lead, which unleashes a pass rush that thrives when opponents become one-dimensional. Special teams have tilted hidden yardage, and the Rams have handled late-game four-minute situations well.
Lions vs Commanders: Lions (-500)
Detroit continues to draw market confidence, and FanDuel lists the Lions as substantial favorites. Their balanced offense led by Jared Goff, plus red-zone creativity travels, and Washington’s margin for error is thin if Detroit’s early-down efficiency holds. We’re laying the chalk on the ML with Jayden Daniels out.
Steelers vs Chargers: Chargers (-154)
Prime time in L.A. favors the Chargers, and the matchup tilts toward the home side’s explosive-pass potential and pass rush. Pittsburgh needs takeaways to swing it; absent that, the Chargers are the better straight-up bet.
Eagles vs Packers: Eagles (+118)
The Eagles’ lines on both sides of the ball tend to travel, and their short-yardage edge can be decisive in a one-score script. Behind a mauling offensive front, Philadelphia sustains drives by winning early downs and converting fourth-and-shorts with the league’s reliable sneak variations.
That rhythm protects the defense, which rushes with four, squeezes explosives, and forces quarterbacks into hurried throws.
In Lambeau’s elements, trench control matters even more: clean pockets for timing routes, downhill doubles for the run game, and manageable third downs. If they avoid turnovers and penalties, the Eagles’ line play tilts hidden yardage and situational football.
ChatGPT has gone 90-44 so far this season for +37.82 units.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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