It’s a classic NFC West showdown at Levi’s Stadium on Sunday, November 9, with the Los Angeles Rams heading north to face the San Francisco 49ers.
This matchup has been golden for the underdog, with the pup covering the spread in 13 of the past 14 meetings between the two clubs.
My Rams vs. 49ers predictions and NFL picks expect Puka Nacua to leave his mark on another close, high-scoring affair.
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Rams vs 49ers prediction
Rams vs 49ers Best bet: Puka Nacua Over 91.5 receiving yards (-114)
Even with the Los Angeles Rams steamrolling the New Orleans Saints in Week 9, and go-to receiver Puka Nacua receiving his final target with 6:25 remaining in the second quarter, he still put up 95 receiving yards while catching seven of eight looks.
It was the fifth time in eight games the reigning Pro Bowler topped 90 receiving yards. Even with a bye week and missing a game, Nacua is fourth in receiving yards (711) and tied for second in receptions (61).
He’s also pacing the NFL in PFF receiving grade with an elite 83.6% catch rate while being targeted on 36.9% of his routes. Nacua also caught 10 of 12 targets for 85 yards against the San Francisco 49ers in Week 5, which, while below this total, still stands as a high-end stat line.
I’m expecting Nacua to be similarly involved this week. The 49ers have been beaten through the air this season, with ranks of 26th in PFF coverage grade and 25th in pass defense DVOA, while also allowing the eighth-highest EPA per dropback and catch percentage to opposing wide receivers.
Rams vs 49ers same-game parlay
The underdog has covered in 13 of the past 14 meetings between these NFC West rivals since 2019, including in five straight games. This spread is giving the Rams a lot of credit on the road, so I like plugging my nose and taking the points with San Fran at Levi's Stadium in Week 10.
While Jauan Jennings has been relatively quiet with 12 receptions for 117 yards on 19 targets the past three weeks, there’s big upside. His 6.2 yards per target is way below his 8.6 mark last year, and the Niners will need to attack through the air to keep up with the Rams on Sunday.
Of course, while the Los Angeles pass defense stacks up with the best of the best statistically, the Rams have still allowed 12 wide receivers to rack up 46 or more receiving yards through eight games.
Rams vs 49ers SGP
- 49ers +4.5
- Jauan Jennings Over 46.5 receiving yards
- Puka Nacua Over 91.5 receiving yards
Our big-ticket SGP: Counting on Kyren
Kyren Williams has found the end zone 37 times across 36 games the past three years, including in 26 of 36, and he’s also piled up 10 red-zone touches the past three.
Rams vs 49ers SGP
- 49ers +4.5
- Jauan Jennings Over 46.5 receiving yards
- Puka Nacua Over 91.5 receiving yards
- Kyren Williams anytime touchdown
Rams vs 49ers odds
- Spread: Rams -4.5 | 49ers +4.5
- Moneyline: Rams -220 | 49ers +184
- Over/Under: Over 49.5 | Under 49.5
More NFL picks and odds from Covers
Rams vs 49ers trend to know
The underdog has covered the spread in 13 of the past 14 games between the Los Angeles Rams and San Francisco 49ers. Find more NFL betting trends for Rams vs. 49ers.
How to watch Rams vs 49ers
| Location | Levi's Stadium, Santa Clara, CA |
| Date | Sunday, November 9, 2025 |
| Kickoff | 4:25 p.m. ET |
| TV | FOX |
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