The Detroit Lions and Buffalo Bills kick off NFL Week 2 with a Thursday Night Football clash at the all-new Highmark Stadium in Orchard Park. The Bills favored by 5.5 points after an impressive road win over the Texans in Week 1.
The Lions also kicked off their season with a win, though they almost squandered a 21-0 lead to the lowly Saints. That performance has moved this spread in Buffalo's favor after opening at -3.5.
With our Covers experts having locked in their best Lions vs. Bills predictions, we'll walk you through all the ways you can watch Thursday Night Football, including how to stream the game through the best legal sports betting sites.
Lions vs Bills game info
| Location | Highmark Stadium, Orchard Park, N.Y. |
| Date | Thursday, Sept. 17, 2026 |
| Kickoff | 8:15 p.m. ET |
| TV | Prime Video |
How to live stream Lions vs Bills
Tonight's Week 2 clash between the Detroit Lions and Buffalo Bills kicks off at 8:15 p.m. ET from Highmark Stadium, as Josh Allen & Co. look to stay undefeated against a second straight quality opponent.
Fans can watch Lions vs. Bills nationally on Amazon Prime Video, but the matchup is also available through NFL+ on mobile devices, which carries live local and nationally televised prime-time games for subscribers.
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📺 How to watch Lions vs Bills on TV
Amazon Prime Video has the national television coverage of tonight's Week 2 Thursday Night Football matchup, with kickoff scheduled for 8:15 p.m. ET.
NFL+ subscribers can watch live prime-time games on supported mobile devices.
📻 How to listen to Lions vs Bills
Lions fans can listen to the game on 97.1 The Ticket (WXYT-FM), featuring play-by-play announcer Dan Miller and analyst Lomas Brown.
Bills fans can listen via the new flagship station 97 Rock (WGRF-FM) in Buffalo (Chris Brown on play-by-play and analyst Eric Wood) or through the Bills Radio Network affiliates across New York, Pennsylvania, and Florida.
Lions vs Bills predictions for Thursday Night Football
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🏈 What is Thursday Night Football?
Thursday Night Football has emerged as a powerhouse anchor for the NFL calendar, kickstarting each slate of action with a high-octane prime-time matchup. The tradition began in November 2006 when the NFL Network introduced the package to give fans an early jump on the weekend. Designed to satisfy an increasing appetite for mid-week gridiron action, it rapidly evolved from a late-season novelty into a weekly staple.
Over the years, Thursday Night Football has delivered fierce divisional rivalries and iconic spectacles like the vibrant Color Rush uniforms. In 2022, Amazon Prime Video took over as the exclusive national broadcaster, marking a historic leap into streaming and ushering the tradition into a digital era. Today, it stands as an essential fixture of the NFL's lineup, setting the tone for the week with top-tier talent and fast-paced energy under the lights.
📆 Thursday Night Football schedule
| Week | Date | Matchup | Time/Network |
|---|---|---|---|
| Week 1 | 9/10 | 49ers at Rams | 8:15 Prime Video |
| Week 2 | 9/17 | Lions at Bills | 8:15 Prime Video |
| Week 3 | 9/24 | Falcons at Packers | 8:15 Prime Video |
| Week 4 | 10/1 | Steelers at Browns | 8:15 Prime Video |
| Week 5 | 10/8 | Buccaneers at Cowboys | 8:15 Prime Video |
| Week 6 | 10/15 | Seahawks at Broncos | 8:15 Prime Video |
| Week 7 | 10/22 | Patriots at Bears | 8:15 Prime Video |
| Week 8 | 10/29 | Panthers at Packers | 8:15 Prime Video |
| Week 9 | 11/5 | Jaguars at Ravens | 8:15 Prime Video |
| Week 10 | 11/12 | Commanders at Giants | 8:15 Prime Video |
| Week 11 | 11/19 | Colts at Texans | 8:15 Prime Video |
| Week 12 | 11/27 | Broncos at Steelers | 8:15 Prime Video |
| Week 13 | 12/3 | Chiefs at Rams | 8:15 Prime Video |
| Week 14 | 12/10 | Vikings at Patriots | 8:15 Prime Video |
| Week 15 | 12/17 | 49ers at Chargers | 8:15 Prime Video |
| Week 16 | 12/24 | Texans at Eagles | 8:15 Prime Video |
| Week 17 | 12/31 | Ravens at Bengals | 8:15 Prime Video |
| Week 18 | 1/7 | There is no TNF matchup scheduled for Week 18. | N/A |
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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