Week 5 of the college football season has arrived, and fans can expect heavyweight clashes between top-ranked contenders, chippy programs with something to prove, and underdogs eager to pull off statement wins.
The atmosphere will be electric in packed stadiums from coast to coast, with every snap magnified under the spotlight.
It’s wall-to-wall action, and we’ve got ChatGPT in the war room.
The generative AI chatbot has crunched the odds, sized up the matchups, and is dropping fearless NCAAF picks and analysis for every Week 5 game featuring an AP Top 25 team.
Strap in. The fireworks are about to fly!
NCAAF Week 5 moneyline picks
| Matchup | Pick |
|---|---|
No. 8  Florida State vs  Virginia |
-255 |
No. 24  TCU vs  Arizona State |
-132 |
No. 16  Georgia Tech vs  Wake Forest |
-600 |
No. 21  USC vs No. 23  Illinois |
-240 |
No. 22  Notre Dame vs  Arkansas |
-178 |
 Utah State vs No. 18  Vanderbilt |
-2100 |
No. 1  Ohio State vs  Washington |
-320 |
No. 4  LSU vs No. 13  Mississippi |
-120 |
 Auburn vs No. 9  Texas A&M |
-230 |
No. 11  Indiana vs  Iowa |
-300 |
No. 15  Tennessee vs  Mississippi State |
-310 |
 Arizona vs No. 14  Iowa State |
-240 |
No. 6  Oregon vs No. 2  Penn State |
-166 |
No. 17  Alabama vs No. 5  Georgia |
-152 |
 Massachusetts vs No. 20  Missouri |
NA |
No. 25  BYU vs  Colorado |
-240 |
Odds courtesy of FanDuel.
No. 8 Florida State vs Virginia
Moneyline prediction: Florida State (-255)
Odds: Florida State -6.5; total 59.5
Florida State is favored by nearly a touchdown on the road, with a -255 moneyline. Virginia has struggled to keep pace with top-tier opponents, and FanDuel’s odds reflect that.
The Seminoles’ offensive balance and athleticism on defense should prove too much. Straight-up, Florida State is the pick.
No. 24 TCU vs Arizona State
Moneyline prediction: Arizona State (-132)
Odds: Arizona State -2.5; total 55.5
This matchup is lined tightly, but Arizona State gets the nod as a small home favorite.
TCU could make things interesting with explosive plays, but AI gives the edge to the Sun Devils at home.
No. 16 Georgia Tech vs Wake Forest
Moneyline prediction: Georgia Tech (-600)
Odds: Georgia Tech -13.5; total 52.5
The Yellow Jackets are among the heaviest favorites of the week, laying nearly two touchdowns with a -600 moneyline.
Wake Forest offers value against the spread but is a long shot to win outright. AI sides with the oddsmakers here.
No. 21 USC vs No. 23 Illinois
Moneyline prediction: USC (-240)
Odds: USC -6.5; total 60.5
Two ranked teams square off in a Big Ten/Pac-12 crossover clash. Illinois has shown resilience, but straight-up, the Trojans’ offensive depth and playmaking give them an edge.
Illinois could cover, but USC is the prediction to win outright.
No. 22 Notre Dame vs Arkansas
Moneyline prediction: Notre Dame (-178)
Odds: Notre Dame -4.5; total 64.5
Notre Dame enters this SEC road test as a slight favorite, and FanDuel’s line reflects a tight contest.
Arkansas can make things messy at home, but Notre Dame’s ability to grind with its offensive line and limit turnovers makes the Irish the safer straight-up pick.
In a high-total game, expect fireworks, but AI rolls with the ranked team.
Utah State vs No. 18 Vanderbilt
Moneyline prediction: Vanderbilt (-2100)
Odds: Vanderbilt -22.5; total 59.5
Vanderbilt is one of the biggest favorites on the board this week, laying more than three touchdowns against Utah State. The Commodores’ moneyline is steep at -2100, reflecting how lopsided this matchup looks on paper.
Utah State’s best shot is a backdoor cover, but AI isn’t overthinking it. Straight-up, Vanderbilt cruises.
No. 1 Ohio State vs Washington
Moneyline prediction: Ohio State (-320)
Odds: Ohio State -8.5; total 52.5
The nation’s top team travels west to face Washington. FanDuel sets the Buckeyes as more than a touchdown favorite, with a -320 moneyline.
Washington has firepower, but AI sticks with Ohio State’s overwhelming depth and track record. It’s Buckeyes all the way.
No. 4 LSU vs No. 13 Mississippi
Moneyline prediction: Mississippi (-120)
Odds: Mississippi -1.5; total 55.5
One of Saturday’s marquee matchups features a near pick’em line. Mississippi is laying just 1.5 points at home, with a slim -120 moneyline.
LSU at +100 is tempting, but AI gives the edge to the Rebels. Home field swings this prediction toward Mississippi in a thriller.
Auburn vs No. 9 Texas A&M
Moneyline prediction: Texas A&M (-230)
Odds: Texas A&M -6.5; total 52.5
This SEC West clash could have divisional implications. Auburn’s spread is within a touchdown, and the Tigers’ moneyline offers value, but straight-up, the Aggies are the safer side.
Texas A&M’s talent edge, especially defensively, should carry it in a tight one.
No. 11 Indiana vs Iowa
Moneyline prediction: Indiana (-300)
Odds: Indiana -7.5; total 48.5
Iowa comes in as the underdog, catching more than a touchdown. FanDuel pegs Indiana as a strong favorite at -300. The Hawkeyes’ style can shorten games and frustrate opponents, but Indiana’s balance on both sides of the ball gives it the edge in a straight-up bet.
No. 15 Tennessee vs Mississippi State
Moneyline prediction: Tennessee (-310)
Odds: Tennessee -7.5; total 62.5
This SEC matchup sets up as another high-scoring game, with the total north of 60. Tennessee’s moneyline sits at -310, and while Mississippi State has shown grit, the Volunteers’ explosive offense is hard to fade.
AI calls this one for Tennessee, trusting its scoring ability to push them past the Bulldogs.
Arizona vs No. 14 Iowa State
Moneyline prediction: Iowa State (-240)
Odds: Iowa State -6.5; total 48.5
Iowa State is favored by nearly a touchdown at home against Arizona. The Cyclones’ defense should be the difference-maker, limiting Arizona’s opportunities in what could be a lower-scoring affair.
With a -240 moneyline, AI is siding with the home team to take care of business straight-up.
No. 6 Oregon vs No. 3 Penn State
Moneyline prediction: Penn State (-166)
Odds: Penn State -3.5; total 52.5
The biggest Top-10 clash of Week 5 pits Penn State against Oregon. The Ducks' explosive playmaking makes them dangerous, but AI sides with Penn State’s overall balance.
In a matchup that could swing playoff implications, the Nittany Lions get the straight-up nod.
No. 17 Alabama vs No. 5 Georgia
Moneyline prediction: Georgia (-152)
Odds: Georgia -2.5; total 52.5
A heavyweight SEC showdown that will draw national attention. Georgia enters as a small road favorite, with a -152 moneyline.
Alabama’s pedigree makes it a live underdog, but AI sticks with Georgia’s depth and coaching stability in what should be a nail-biter. The Bulldogs are the straight-up call.
Massachusetts vs No. 20 Missouri
Moneyline prediction: Missouri
Odds: Missouri -44.5; total 56.5
FanDuel currently has Missouri’s moneyline locked, but the spread tells the story. Laying more than six touchdowns against Massachusetts, the Tigers are overwhelming favorites.
Even without an available moneyline, AI’s straight-up pick is Missouri with ease.
No. 25 BYU vs Colorado
Moneyline prediction: BYU (-240)
Odds: BYU -6.5; total 47.5
BYU rounds out the ranked slate as a one-score favorite over Colorado.
Colorado should compete, but BYU’s defensive edge and consistency earn the Cougars the straight-up prediction.
ChatGPT has gone 68-12 so far this season for +54.8 units.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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