Alabama will look to avenge last year's upset loss at the hands of Vanderbilt in a rematch that headlines the Week 6 college football slate. Meanwhile, Miami heads to Tallahassee for a date with Florida State.
I pick a side in those matchups and many more in my Week 6 ATS college football picks below.
College football picks against the spread for Week 6
| Matchup | Pick |
|---|---|
 Kentucky vs  Georgia |
(-20.5) |
 Wisconsin vs  Michigan |
(+16.5) |
 Vanderbilt vs  Alabama |
(+10.5) |
 Texas vs  Florida |
(-6.5) |
 Boise State vs  Notre Dame |
(+20.5) |
 Texas Tech vs  Houston |
(+11.5) |
 Minnesota vs  Ohio State |
(-23.5) |
 Miami vs  Florida State |
(+4.5) |
Lines courtesy of FanDuel.
Expert Week 6 NCAAF ATS picks
Kentucky vs Georgia (-20.5): Georgia -20.5
This is wrong place, wrong time for Kentucky. Georgia is coming off yet another Alabama loss and will be taking that frustration out on the visiting Wildcats.
Read our full Georgia vs. Kentucky predictions.
Wisconsin vs Michigan (-16.5): Wisconsin +16.5
There's not a ton to love about Wisconsin at the moment, but this is still a ton of points for a Michigan team with a limited passing game.
Read our full Wisconsin vs. Michigan predictions.
Vanderbilt vs Alabama (-10.5): Vanderbilt +10.5
This number has crept past 10, and that's more than enough for me to justify taking the points. This is the same Vanderbilt team that sent Alabama into a deep spiral a year ago.
Read our full Vanderbilt vs. Alabama predictions.
Texas (-6.5) vs Florida: Texas -6.5
I've seen more than enough from Florida's offense to know it can't be trusted: 33 points in its last three games, one of which was an upset home loss to South Florida. Lay the number.
Read our full Texas vs. Florida predictions.
Boise State vs Notre Dame (-20.5): Boise State +20.5
Notre Dame's offense is cooking right now, but so is Boise State's. I think the Broncos score just enough to keep this inside the number, and there's also room for a backdoor cover if needed.
Read our full Boise State vs. Notre Dame predictions.
Texas Tech (-11.5) vs Houston: Houston +12
Both of these teams enter at 4-0, but while Texas Tech's defensive line will lead the Red Raiders to victory, the Cougars can do enough on both sides to keep things in check.
Read our full Texas Tech vs. Houston predictions.
Minnesota vs Ohio State (-23.5): Ohio State -23.5
It's just hard to imagine Minnesota (or most teams, for that matter) producing enough offense to keep this number in play.
Read our full Minnesota vs. Ohio State predictions.
Miami (-4.5) vs Florida State: Florida State +4.5
Miami's defense is the best unit in this game, but with the spread well beyond a field goal, I'll take the points with the home side in this rivalry affair.
Read our full Miami vs. Florida State predictions.
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My college football ATS/ML record is 20-24 this season for -5.45 units.
Odds are correct at the time of publishing and are subject to change.
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