Alabama will look to avenge last year's upset loss at the hands of Vanderbilt in a rematch that headlines the Week 6 college football slate. Meanwhile, Miami heads to Tallahassee for a date with Florida State.
I pick a side in those matchups and many more in my Week 6 ATS college football picks below.
College football picks against the spread for Week 6
| Matchup | Pick |
|---|---|
 Kentucky vs  Georgia |
(-20.5) |
 Wisconsin vs  Michigan |
(+16.5) |
 Vanderbilt vs  Alabama |
(+10.5) |
 Texas vs  Florida |
(-6.5) |
 Boise State vs  Notre Dame |
(+20.5) |
 Texas Tech vs  Houston |
(+11.5) |
 Minnesota vs  Ohio State |
(-23.5) |
 Miami vs  Florida State |
(+4.5) |
Lines courtesy of FanDuel as of 9-30.
Expert Week 6 CFB ATS picks
Kentucky vs Georgia (-20.5): Georgia -20.5
This is wrong place, wrong time for Kentucky. Georgia is coming off yet another Alabama loss and will be taking that frustration out on the visiting Wildcats.
Wisconsin vs Michigan (-16.5): Wisconsin +16.5
There's not a ton to love about Wisconsin at the moment, but this is still a ton of points for a Michigan team with a limited passing game.
Vanderbilt vs Alabama (-10.5): Vanderbilt +10.5
This number has crept past 10, and that's more than enough for me to justify taking the points. This is the same Vanderbilt team that sent Alabama into a deep spiral a year ago.
Texas (-6.5) vs Florida: Texas -6.5
I've seen more than enough from Florida's offense to know it can't be trusted: 33 points in its last three games, one of which was an upset home loss to South Florida. Lay the number.
Boise State vs Notre Dame (-20.5): Boise State +20.5
Notre Dame's offense is cooking right now, but so is Boise State's. I think the Broncos score just enough to keep this inside the number, and there's also room for a backdoor cover if needed.
Texas Tech (-11.5) vs Houston: Houston +12
Both of these teams enter at 4-0, but while Texas Tech's defensive line will lead the Red Raiders to victory, the Cougars can do enough on both sides to keep things in check.
Minnesota vs Ohio State (-23.5): Ohio State -23.5
It's just hard to imagine Minnesota (or most teams, for that matter) producing enough offense to keep this number in play.
Miami (-4.5) vs Florida State: Florida State +4.5
Miami's defense is the best unit in this game, but with the spread well beyond a field goal, I'll take the points with the home side in this rivalry affair.
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My college football ATS/ML record is 20-24 this season for -5.45 units.
Odds are correct at the time of publishing and are subject to change.
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