Reds vs Blue Jays Prediction, Odds & Home Run Pick for Today's MLB Game

Dustin Saracini -  - Betting Analyst at Covers.com
Dustin Saracini • Betting Analyst 14+ years betting experience
Updated: Sep 25, 2026 , 09:56 AM ET • 4 min read

I'm comfortably fading Nick Lodolo in this spot, who's having one of the worst seasons of his five-year career. Lodolo owns the highest xERA (6.42), xSLG (.486), xBA (.293) since breaking into the league in 2022.

mlb

Match starts: 5 hrs
Photo By - Reuters Connect - Toronto Blue Jays designated hitter George Springer (4) celebrates in the dugout.

Toronto may be limping to the finish line, but we'e going to ride with them today as part of our Reds vs. Blue Jays prediction.

The Toronto Blue Jays host the Cincinnati Reds for the final homestand of the season as -135 favorites at BET99. Can Jose Soriano give the fans something to cheer about?

Here are my free MLB picks for Friday, Sept. 25.

Reds vs Blue Jays predictions

Reds vs Blue Jays best bet: Toronto Blue Jays Moneyline (-135)

I'm comfortably fading Nick Lodolo in this spot, who's having one of the worst seasons of his five-year career. Lodolo owns the highest xERA (6.42), xSLG (.486), xBA (.293) since breaking into the league in 2022, and has coughed up three or more earned runs in five of his last six starts.

Jose Soriano will be making his final start at home and limited this team to a seven-inning, two-hit, 10-strikeout shutout earlier this year while he was still with the Los Angeles Angels. 

The Toronto Blue Jays may be limping to the finish line, but should be able to give the crowd something to cheer about today

I'd play this to -140.

Covers COVERS INTEL: The Reds ground into the second-most double plays per game (0.53) in Major League Baseball, which should play into Soriano's elite groundball rate (53.5%).

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Reds vs Blue Jays same-game parlay (SGP)

On top of having the worst season of his career, Lodolo's strikeout numbers are also incredibly low, punching out hitters at just a 17% clip.

This leads to balls in play, runners, and, ultimately, runs. Enter George Springer, who is likely playing in his final games as a Blue Jay. Expect him to have himself a series in what should be an emotional exit.

Reds vs Blue Jays SGP

  • Toronto Blue Jays moneyline
  • George Springer 2+ H/R/RBI
  • Nick Lodolo Under 4.5 strikeouts

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Regulated Alberta sports betting has officially launched, allowing sportsbooks to operate under provincial oversight.

You can sign up and join BET99 — one of the best Alberta betting apps — now to get in on the Blue Jays action!

Reds vs Blue Jays home run pick: George Springer (+475)

Springer loves lefties, and he mashes at home, owning a .813 OPS at the Rogers Centre this season. With his emotional exit incoming, expect him to lock in for the final series.

Lodolo is the perfect guy to tee off on, coming in with a .486 xSLG against. Bombs away for the Blue Jays tonight.

2026 Transparency Record
  • Best bets: 12-16, -2.87 units 
  • SGPs: 5-25, -0.80 units

Reds vs Blue Jays odds

  • Moneyline: Cincinnati (+115) | Toronto (-135)
  • Run line: Cincinnati +1.5 (-175) | Toronto -1.5 (+150)
  • Over/Under: Over 7.5 (-115) | Under 7.5 (-105)

Reds vs Blue Jays trend

Nick Lodolo has lost three straight starts for the Reds. Find more MLB betting trends for Reds vs. Blue Jays.

How to watch Reds vs Blue Jays and game info

Location Rogers Centre, Toronto, ON
Date Friday, September 25, 2026
First pitch 7:07 p.m. ET
TV Sportsnet
Reds starting pitcher Nick Lodolo
(3-6, 5.04 ERA)
Blue Jays starting pitcher Jose Soriano
(12-8, 3.72 ERA)

Reds vs Blue Jays latest injuries

Reds vs Blue Jays weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Dustin Saracini
Betting Analyst

Dustin Saracini is a betting analyst at Covers with over 14 years of experience in the sports betting industry. Throughout his career, Dustin has hosted multiple betting shows- breaking down NBA, NFL, PGA, and MLB markets alongside top handicappers - and has appeared as a Super Bowl consultant for CNN. A disciplined daily bettor who extensively line-shops across FanDuel, DraftKings, BetMGM, and Caesars, his sharpest edges lie in MLB and the NFL (followed closely by the NHL and NBA). A self-proclaimed NRFI guru targeting his second straight +10u MLB season, Dustin holds a Broadcast Journalism degree from Western University (2014). For daily picks, market strategies, and insights, follow him on X (Twitter) @DustinSaracini.

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