The Boston Red Sox will look to complete a three-game sweep as they wrap up their road series against the Detroit Tigers tonight.
Detroit will send the wild Jack Flaherty to the mound, which is why I’m taking Boston to win in my Red Sox vs. Tigers predictions.
Read on to learn more and get my free MLB picks for Wednesday, May 6.
Who will win Red Sox vs Tigers today: Red Sox moneyline (+102)
Detroit Tigers starter Jack Flaherty (0-2, 5.90 ERA) is suffering through the worst stretch of his career. Flaherty leads the AL in walks, allowing 7.8 free passes per nine innings, which has ballooned his WHIP to 1.793 over his first seven starts.
Flaherty hasn’t made it out of the fourth inning in any of his last three starts. That includes an April 20 appearance against the Boston Red Sox in which he walked six batters in 3.1 innings of work.
Boston teed off against Framber Valdez yesterday and should produce more than enough offense again tonight to finish off a series sweep.

Red Sox vs Tigers Over/Under pick: Over 8.5 (-105)
I don’t see the Red Sox needing much help to hit the Over tonight, but the Tigers should put up a few runs to help against Sonny Gray. The Boston starter is coming off the IL after suffering a hamstring strain in his last start against Detroit.
The Tigers have been league-average in terms of scoring but far more effective against righties, hitting to a .743 OPS against right-handed pitching this year.
Detroit’s .344 xwOBA is the fourth best in the league, suggesting it's better than its results have shown. That’s enough firepower to bring the total to the Over.
- ML/RL bets: 5-11, -6.31 units
- Over/Under bets: 5-9, -4.43 units
Red Sox vs Tigers odds
- Moneyline: Red Sox -108 | Tigers -112
- Run line: Red Sox -1.5 (+144) | Tigers +1.5 (-175)
- Over/Under: Over 8.5 (-112) | Under 8.5 (-112)
Red Sox vs Tigers trend
The Red Sox and Tigers have combined to hit the Over in four straight meetings. Find more MLB betting trends for Red Sox vs. Tigers.
How to watch Red Sox vs Tigers and game info
| Location | Comerica Park, Detroit, MI |
| Date | Wednesday, May 6, 2026 |
| First pitch | 6:40 p.m. ET |
| TV | NESN, DSN |
| Red Sox starting pitcher | Sonny Gray (2-1, 4.30 ERA) |
| Tigers starting pitcher | Jack Flaherty (0-2, 5.90 ERA) |
Red Sox vs Tigers latest injuries
Red Sox vs Tigers weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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