Pirates vs Diamondbacks Prediction, Picks & Odds for Today’s MLB Game

The Pirates can't hit and go up against Diamondbacks ace Corbin Burnes who, after a rocky start to his Arizona tenure, has settled in nicely in the desert. The D-Backs will win by multiple runs tonight.

JD Yonke - Contributor at Covers.com
JD Yonke • Contributor
May 27, 2025 • 10:00 ET • 4 min read

MLB

Match starts: 5 hrs
AZ
80 %
PIT
20 %
EXPERT PICK - RUN LINE
Arizona -1.5 (-125) Arizona -1.5 (-125)
Read Analysis
Corbin Burnes Arizona Diamondbacks MLB
Photo By - Imagn Images. D-Backs ace Corbin Burnes throws a pitch in 2025.

The Arizona Diamondbacks host the Pittsburgh Pirates tonight at Chase Field.

With ace Corbin Burnes on the mound, my Pirates vs. Diamondbacks predictions give Arizona the upper hand against Pittsburgh's paltry attack. 

Read on for my MLB picks for Tuesday, May 27.

Pirates vs Diamondbacks prediction

My Pirates vs Diamondbacks best bet: Diamondbacks -1.5 (-125 at DraftKings)

The Arizona Diamondbacks picked up a much-needed win on Monday, snapping a five-game losing skid with a 5-0 victory. 

The Pittsburgh Pirates offense struggled yet again, which has been quite the theme of the season. With Corbin Burnes on the bump tonight, it’s hard to fancy Pittsburgh's chances of an offensive breakout. 

The 30-year-old hurler has been on top of his game, allowing five combined earned runs across his last five starts (31 1/3 IP).

Pittsburgh’s anemic offense ranks second-last in both wOBA (.289) and wRC+ (79) against right-handed pitching.

Failing to score runs makes it hard to win baseball games, so, unsurprisingly, the Pirates have one lonely win in their last 12 road games. They’re just 6-20 away from PNC Park this season.

Mike Burrows will make his second career start after allowing four earned runs on four hits, two walks, and two home runs across five innings in his debut against Milwaukee. 

Most projection systems paint the 25-year-old with an ERA in the mid-4.00s, well below Burnes’ 2.73. 

Arizona has been one of the better lineups against right-handed pitching, ranking third in wRC+ (122) and first in wOBA (.351).

The Diamondbacks have picked up wins in three of Burnes’ last four starts with a +14 run differential.

The National League wild card is going to be highly competitive, and Arizona knows it must get back on track after the recent losing streak. Burnes gives the home team a good chance of doing just that, plus the D-Backs have the advantage at the dish.

Pirates vs Diamondbacks same-game parlay (SGP)

Diamondbacks -1.5

Under 9

Corbin Carroll 2+ total bases

Pittsburgh has been dead set on the Under, going 5-14 O/U in its last 19 games. The Pirates’ season-long record is 20-32 O/U thanks to their dreadful offense, and they have a tough opponent on Tuesday.

Arizona has cashed the Under in four straight Burnes starts and 17 of their last 25 games overall, so we're betting on a low-scoring game between two teams trending in the same direction.

Betting on Corbin Carroll to go Over his 1.5 total bases prop may seem counterintuitive to this same-game parlay, but there is still plenty of room for him to record 2+ total bases and for this game to go Under the total. 

The 24-year-old has a 156 wRC+ against right-handed pitchers and is better at home (157 wRC+) than on the road (127 wRC+).

Pirates vs Diamondbacks odds

Pirates vs Diamondbacks live odds

Pirates vs Diamondbacks opening odds

  • Moneyline: Pittsburgh +205 | Arizona -250
  • Run line: Pittsburgh +1.5 (+105) | Arizona -1.5 (-125)
  • Over/Under: Over 9 (+100) | Under 9 (-120)

Pirates vs Diamondbacks trend

Pittsburgh is 1-3 to the run line in its last four away games. Find more MLB betting trends for Pirates vs. Diamondbacks.

How to watch Pirates vs Diamondbacks and game info

Location Chase Field, Phoenix, AZ
Date Tuesday, 5-27-2025
First pitch 9:40 p.m. ET
TV SportsNet Pittsburgh, ARID
Pirates starting pitcher Mike Burrows
(0-1, 7.20 ERA)
Diamondbacks starting pitcher Corbin Burnes
(3-2, 2.73 ERA)

Pirates vs Diamondbacks latest injuries

Pirates vs Diamondbacks weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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JD Yonke
Contributor

JD is a diehard college football fan with five years of experience writing betting and fantasy content for publications such as SportsGrid, Fantasy Points, Fantrax, and Devy Watch. An avid reader, he uses his inclination to look at things with an exhausting and in-depth, analytic viewpoint combined with a love for statistics and metrics to form a well-rounded handicapping approach.

e's an integral member of the niche (but growing!) college fantasy football community, twice traveling to Canton, OH for the Fantasy Football Expo as a member of the CFF King's Classic drafting squad. His specialization in college football DFS and prop betting taught him that there are exploitable markets to be found and that narrowing your focus is integral to being a profitable bettor.

A lifelong Californian who grew up playing baseball, basketball, football, and lacrosse, he's glad to share a passionate love for sports with this wonderful community.

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