The Philadelphia Phillies head to Petco Park tonight to begin a three-game series with the San Diego Padres. The first pitch is scheduled for 6:40 p.m. ET.
My Phillies vs. Padres predictions are eyeing the visitors to win the opener, with Jesus Luzardo bringing his best on the mound.
Read more in my MLB picks for Monday, May 25.
Who will win Phillies vs Padres today: Phillies moneyline (-120)
The Philadelphia Phillies head into tonight’s matchup riding a four-game road winning streak, and Jesus Luzardo has been far more effective away from home.
The left-hander owns a stellar 1.52 ERA in four road outings compared to a 7.31 ERA at Citizens Bank Park. Luzardo has also allowed just two earned runs across his last two starts away from Philly.
The San Diego Padres counter with Randy Vasquez, whose ERA jumps from 2.96 overall to 4.20 at Petco Park. Philadelphia’s lineup has also enjoyed success against him, batting .500 in 20 at-bats led by Bryce Harper, Alec Bohm, and Kyle Schwarber.
COVERS INTEL: Luzardo owns a 3.20 xERA this season, and he's in the top 10 of the MLB in lowest hard hit rate. 
Phillies vs Padres Over/Under pick: Under 7.5 (-115)
Recent meetings between these clubs have been low-scoring, with the Under cashing in three of the last four matchups. Luzardo appears to be settling into a groove, while Vasquez typically keeps damage limited despite occasional struggles at Petco Park.
Offense has also been an issue for both teams this season. The Phillies rank 21st in MLB in runs scored, while the Padres sit 19th. Both bullpens have been reliable, each carrying sub-4.00 ERAs.
Philadelphia has hit the Under in eight of its last 10 games, while San Diego has stayed below 7.5 runs in three of its previous four contests.
- ML/RL bets: 16-11, +5.54 units
- Over/Under bets: 15-11, +1.09 units
Phillies vs Padres odds
- Moneyline: Phillies -117 | Padres +113
- Run line: Phillies -1.5 (+150) | Padres +1.5 (-156)
- Over/Under: Over 7.5 (+108) | Under 7.5 (-113)
Phillies vs Padres trend
The Phillies have cashed the Under in total runs in eight of their last 10 games. Find more MLB betting trends for Phillies vs. Padres.
How to watch Phillies vs Padres and game info
| Location | Petco Park, San Diego, CA |
| Date | Monday, May 25, 2026 |
| First pitch | 6:40 p.m. ET |
| TV | NBC Sports Philadelphia, Padres.TV |
| Phillies starting pitcher | Jesus Luzardo (3-4, 4.85 ERA) |
| Padres starting pitcher | Randy Vasquez (5-2, 2.96 ERA) |
Phillies vs Padres latest injuries
Phillies vs Padres weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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