It’s Shohei Ohtani Day at Daikin Park as the Los Angeles Dodgers face the Houston Astros on May 5.
My Dodgers vs. Astros predictions and MLB picks expect Los Angeles to come away with the win in what will be a low-scoring affair.
Who will win Dodgers vs Astros today: Dodgers (-225)
Shohei Ohtani is an early leader for the Cy Young, allowing just two earned runs over his first 30 frames.
He gives the Los Angeles Dodgers a substantial starting pitching edge over the Houston Astros. Although Peter Lambert has been effective (3.52 ERA), he’ll likely regress toward his 6.12 career ERA given his underwhelming stuff (93 Stuff+).
When it gets to the bullpen, Houston has a league-worst 6.22 ERA in relief. The arms are taxed after essentially throwing two consecutive bullpen games, making this a tough spot.
COVERS INTEL: Houston thrives by hitting for average (.284), but it’ll be difficult to string together hits against Ohtani and his .183 xBA. 
Dodgers vs Astros Over/Under pick: Under 8.5 (-115)
The Under has hit in four of the five games Ohtani has started, and I’m going to keep riding that trend until it stops reaping profit.
It works twofold. On the mound, he’s arguably been the sport’s best starting pitcher, suppressing runs at an elite rate. Since Dave Roberts has been removing Ohtani from the lineup on days he starts lately, it deprives the Boys in Blue of their best hitter.
L.A. has been slumping at the plate lately, averaging 3.2 runs across its last six games. Without Ohtani, Mookie Betts, and Tommy Edman in the lineup, this may not be a “blow-up” offensive spot but more of a low-scoring win instead.
- ML/RL bets: 9-8, +0.14 units
- Over/Under bets: 12-6, +5.7 units
Dodgers vs Astros odds
- Moneyline: Dodgers -220 | Astros +212
- Run line: Dodgers -1.5 (-130) | Astros +1.5 (+110)
- Over/Under: Over 8.5 (-105) | Under 8.5 (-115)
Dodgers vs Astros trend
The Dodgers have hit the Under in five of their last seven away games. Find more MLB betting trends for Dodgers vs. Astros.
How to watch Dodgers vs Astros and game info
| Location | Daikin Park, Houston, TX |
| Date | Tuesday, May 5, 2026 |
| First pitch | 8:10 p.m. ET |
| TV | TBS |
| Dodgers starting pitcher | Shohei Ohtani (2-1, 0.60 ERA) |
| Astros starting pitcher | Peter Lambert (1-2, 3.52 ERA) |
Dodgers vs Astros latest injuries
Dodgers vs Astros weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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