Get free expert and computer MLB picks for every game on May 21, 2026. With over 25 years of betting experience, our analysts and predictive models help you find the best value.
CLE
@
DET
Thu, May 21 • 1:10 PM ET
u7.5 (-125)
CLE (+100)
The Tigers are missing three key players (Torres, Baez, Carpenter) and have fallen off a cliff, going 2-13 over their last 15 while scoring just 2.47 runs per game over that span.
The Guardians are hot with eight wins in their last nine and rank second in runs as well as third in OBP among all teams this month.
PIT
@
STL
Thu, May 21 • 1:15 PM ET
NYM
@
WAS
Thu, May 21 • 4:05 PM ET
ATL
@
MIA
Thu, May 21 • 6:40 PM ET
ATL (-140)
TOR
@
NYY
Thu, May 21 • 7:05 PM ET
NYY (-160)
Carlos Rodón has some redemption on his mind after a shaky, costly return in the Subway Series for the New York Yankees. As they wrap up their current series against an AL East rival, he’ll need to capitalize on a Toronto Blue Jays lineup that’s hitting just .225 against left-handers this season. Rodón has a 2-3 record with an ERA of 4.72 and 54 strikeouts in 9 appearances against the Blue Jays in his career, but this Toronto team looks like a shell of themselves to start the season. Take the home team to best the Jays as Rodón shakes off the rust and slowly, but surely finds his rhythm again on the mound.
ATH
@
LAA
Thu, May 21 • 9:38 PM ET
ATH (-104)
José Soriano has struggled mightily against the Athletics, going 1-3 with a 9.00 ERA and 33 strikeouts in eight career outings — numbers that should have the AL West-leading A’s feeling confident heading into Thursday’s finale. It also sets the stage for Shea Langeliers, who’s been on fire with a .328 average, hitting .326 against right-handers and already launching 12 home runs this season. Expect Soriano to run into trouble again, with Langeliers likely playing a major role.
COL
@
AZ
Thu, May 21 • 9:40 PM ET
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