MLB Picks

Get free expert and computer MLB picks for every game on May 21, 2026. With over 25 years of betting experience, our analysts and predictive models help you find the best value.

Cleveland Guardians logo CLE @ Detroit Tigers logo DET Thu, May 21 • 1:10 PM ET
2 Expert Picks 10 Computer Picks
Total
Cleveland Guardians logo Detroit Tigers logo u7.5 (-125)
Best Odds
Pick made: 11 hours ago
Chris Faria image
Chris Faria
Betting Analyst

Tigers starter Casey Mize has a stingy 2.43 ERA and ranks in the 85th percentile in xBA (.211).

Detroit can’t score, Mize won’t give up a ton, and both teams have bullpens with a sub-4.00 ERA. 

Moneyline
Cleveland Guardians logo CLE (+100)
Best Odds
Pick made: 11 hours ago
Chris Faria image
Chris Faria
Betting Analyst

The Tigers are missing three key players (Torres, Baez, Carpenter) and have fallen off a cliff, going 2-13 over their last 15 while scoring just 2.47 runs per game over that span.

The Guardians are hot with eight wins in their last nine and rank second in runs as well as third in OBP among all teams this month.

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Pittsburgh Pirates logo PIT @ St. Louis Cardinals logo STL Thu, May 21 • 1:15 PM ET
2 Expert Picks 10 Computer Picks
Total
Pittsburgh Pirates logo St. Louis Cardinals logo o7.5 (-110)
Best Odds
Pick made: 4 hours ago
Quinn Allen image
Quinn Allen
Betting Analyst

The Over has hit in four of the last five meetings between these clubs, and both pitchers have vulnerabilities. The Cardinals have previously hit Ashcraft well, while May is allowing hard contact at a career-worst rate. With Pittsburgh scoring 13 runs in the last two games and St. Louis’ bullpen posting a 4.53 ERA, runs should come from both sides.

Moneyline
Pittsburgh Pirates logo PIT (-125)
Best Odds
Pick made: 4 hours ago
Quinn Allen image
Quinn Allen
Betting Analyst

Pittsburgh has all the momentum after a dominant 7-0 win on Wednesday, and Braxton Ashcraft continues to impress with a strong 2.16 road ERA. While Dustin May has struggled against the Pirates lineup and owns a shaky 4.50 home ERA, Pittsburgh’s offense is producing nearly five runs per game and should stay hot in the series finale.

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New York Mets logo NYM @ Washington Nationals logo WAS Thu, May 21 • 4:05 PM ET
3 Expert Picks 8 Computer Picks
Total
New York Mets logo Washington Nationals logo o7.5 (-122)
Best Odds
Pick made: 44 minutes ago
Ed Scimia image
Ed Scimia
Betting Analyst

The Nationals have been the best offensive team in the majors so far this season, scoring 5.58 runs per game. The Mets lineup is waking up as well, with both Juan Soto and Bo Bichette showing tremendous power in this series. These teams have consistantly had slugfests this year, and I'm taking the Over tonight.

Moneyline
Washington Nationals logo WAS (+100)
Best Odds
Pick made: an hour ago
Ed Scimia image
Ed Scimia
Betting Analyst

David Peterson is 2-4 with a 5.40 ERA this season, and while he’s been better working behind an opener, his stuff still isn’t what it once was. Peterson is allowing a hard-hit rate of 45.3%, and has seen his WHIP balloon to 1.569. The Nationals offense has already hit him hard once this year, and I'm backing Washington to win again tonight.

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Atlanta Braves logo ATL @ Miami Marlins logo MIA Thu, May 21 • 6:40 PM ET
6 Expert Picks 10 Computer Picks
Runs
Ronald Acuna Jr. logo Ronald Acuna Jr. o0.5 Runs (-106)
Best Odds
Pick made: 1 hours ago
Quinn Allen image
Quinn Allen
Betting Analyst

Ronald Acuna Jr. has wasted no time making an impact after coming back from injury, scoring four runs in his last two games and cashing this prop in four straight. He also owns excellent career numbers against Sandy Alcantara, giving him another strong opportunity to get on base and cross the plate.

Total Home Runs
Ronald Acuna Jr. logo Ronald Acuna Jr. o0.5 Total Home Runs (+490)
Best Odds
Pick made: 1 hours ago
Jon Metler image
Jon Metler
Betting Analyst

Ronald Acuña Jr. is trading at +490 to hit a home run on Thursday, and we are definitely hitting the button on that number, as I price Acuña closer to +350 to go deep. This is a strong edge on a home run prop, and while Sandy Alcantara is one of the better starting pitchers in MLB, Acuña has seen him plenty as a division rival and owns a 1.137 OPS against him in 38 career at-bats. There’s nothing I love more than a mathematical edge on a home run prop for one of the elite players in the game, especially when that player also has extensive familiarity with the opposing starter—and that’s exactly the situation we have with Acuña Jr.

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Toronto Blue Jays logo TOR @ New York Yankees logo NYY Thu, May 21 • 7:05 PM ET
4 Expert Picks 10 Computer Picks
Total RBIs
Vladimir Guerrero Jr. logo Vladimir Guerrero Jr. o0.5 Total RBIs (+187)
Best Odds
Pick made: an hour ago
Quinn Allen image
Quinn Allen
Betting Analyst

Vladimir Guerrero Jr. has historically crushed Carlos Rodon, going 11-for-18 with seven RBIs against the Yankees left-hander. He’s already driven in runs in both games of this series, and with Toronto’s star swinging well on the road, the plus-money value stands out here.

Total Home Runs
Vladimir Guerrero Jr. logo Vladimir Guerrero Jr. o0.5 Total Home Runs (+550)
Best Odds
Pick made: 1 hours ago
Jon Metler image
Jon Metler
Betting Analyst

Carlos Rodón has returned from injury, but he hasn’t looked sharp by any means, posting a 5.63 ERA through his first two starts. Meanwhile, Vladimir Guerrero Jr. has historically had a ton of success against him—even when Rodón was at his best. I usually don’t put much weight into BVP, but Guerrero Jr. going 11-for-18 with two home runs against Rodón is impossible to ignore. That’s complete domination, and +550 feels like a massive number for a hitter with that kind of track record against this pitcher. Even at his peak, Rodón has been vulnerable to right-handed power, and now he’s still working his way back into form after the injury. The familiarity edge almost always favors the hitter, and Guerrero Jr. clearly sees Rodón extremely well.

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Athletics Athletics logo ATH @ Los Angeles Angels logo LAA Thu, May 21 • 9:38 PM ET
6 Expert Picks 10 Computer Picks
Total Home Runs
Shea Langeliers logo Shea Langeliers o0.5 Total Home Runs (+350)
Best Odds
Pick made: 1 hours ago
Josh Inglis image
Josh Inglis
Betting Analyst

José Soriano has fallen out of form, allowing 15 runs over his last 22 innings. The command is wavering, the double-digit strikeouts are no longer showing up, and Langeliers has been a major problem for him. The BlastContact darling has already taken Soriano deep twice in 11 at-bats while posting a 1.765 OPS in the matchup. He hasn’t had the best series so far, but getting plunked twice yesterday could provide some added motivation for a hitter sitting on 12 home runs and batting .322. Only four players own a higher slugging percentage than Langeliers this season. The Los Angeles Angels bullpen is also capable of cashing this HR prop. It owns the second-worst ERA on the season, and that mark has been even uglier over the last two weeks at a 6.60 ERA. It’s extremely fly-ball heavy, and its HR/FB rate also sits in the bottom three in baseball.

Moneyline
Los Angeles Angels logo LAA (-106)
Best Odds
Pick made: 1 hours ago
Jon Metler image
Jon Metler
Betting Analyst

José Soriano will get the ball for the Los Angeles Angels, and I believe he should be a much bigger favorite against the Athletics on Thursday. The Athletics lineup is built around launch angle and three-run home runs, and that’s exactly the type of offense Soriano is elite at neutralizing. Soriano relies on a heavy, high-velocity sinker that generates a ton of ground balls, which is a nightmare matchup for this Athletics lineup. His pitch profile should allow him to keep the ball out of the air and limit the damage from the Athletics power hitters. The Angels are trading at -106 on the moneyline, but I price them closer to -135, which is why I’m hitting the button.

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Colorado Rockies logo COL @ Arizona Diamondbacks logo AZ Thu, May 21 • 9:40 PM ET
3 Expert Picks 10 Computer Picks
Total Home Runs
Nolan Arenado logo Nolan Arenado o0.5 Total Home Runs (+630)
Best Odds
Pick made: 1 hours ago
Jon Metler image
Jon Metler
Betting Analyst

Give me the hot bat, the revenge angle, and a price that’s far too long for Nolan Arenado to hit a home run, and I’ll bet that scenario every day of the week. Zach Agnos is expected to serve as the opener, with Tanner Gordon handling the bulk of the innings afterward. Based on their pitching profiles, both matchups set up well for Arenado, who has been red hot with a 1.188 OPS over the last seven days. What I also love is that Arenado hits behind Corbin Carroll in the lineup. If the Colorado Rockies bring in a left-handed reliever to face Carroll, Arenado could gain the platoon advantage later in the game once the starters exit. I price Arenado closer to +480 to hit a home run on Thursday.

 

Total Home Runs
Corbin Carroll logo Corbin Carroll o0.5 Total Home Runs (+445)
Best Odds
Pick made: 3 hours ago
Josh Inglis image
Josh Inglis
Betting Analyst

The Arizona Diamondbacks have a great hitting matchup today as the Colorado Rockies are rolling with call-up Zach Agnos, who hasn’t started a game this year and will likely hand things off early to a Colorado bullpen that owns the second-worst ERA over the last two weeks and ranks 28th in HR/FB rate over that stretch. Corbin Carroll got the day off yesterday, but before that, he had ripped triples in back-to-back games and, three games ago, launched a pair of home runs against the Rockies and this bullpen. It’s also nice to get a Top-10 bat sitting right at +EV with a fair price around +360. Over the last two weeks, Carroll ranks eighth in BlastContact, third in slugging, and second in ISO. On this small slate, he projects as the third-most likely player to go deep behind only Aaron Judge and Mike Trout.

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