Matchweek 5 of the 2026-27 Premier League season is here, with 10 matches spread across Friday, Saturday, and Sunday and several intriguing betting spots across the board.
Our Premier League predictions cover every Matchweek throughout the season, with expert analysis across moneylines, spreads, totals, props, and more. Each week, we'll break down the biggest betting angles and identify where the market may be offering value.
This page is your home for our latest EPL picks, with best bets and matchup analysis updated throughout the season as lines move and new information becomes available.
This week, I'm backing Leeds to keep rolling at Elland Road, targeting another low-scoring Tottenham performance against Aston Villa, and taking a shot on Fulham and Manchester United sharing the points at Craven Cottage.
EPL picks this week
Chris Vasile's top picks
Season record:5-7.
| Bet Type | Pick |  |
|---|---|---|
| ⭐ Top Pick | Leeds United to win | 56% |
| ⚽ Best Total | Tottenham/Aston Villa Under 2.5 goals | 49% |
| 🎲 Wild Card | Fulham/Manchester United draw | 26% |
Percentages courtesy of Kalshi. Odds are subject to change.
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Premier League predictions & analysis
⭐ Top pick — Leeds United win vs Crystal Palace
Leeds have quickly turned Elland Road back into one of the Premier League's tougher places to visit. They're unbeaten through four league matches and are coming off their best performance yet, hammering Newcastle 4-1 on Monday.
Now the schedule gives them another edge. Crystal Palace played in Europe on Thursday, beating Lech Poznan 4-0, and have a short turnaround before Sunday's trip to Yorkshire. Palace are also dealing with injuries in attack, while Leeds enter with form, rest, and home-field advantage all working in their favor.
I'm backing Leeds to keep their unbeaten start alive with another three points.
⚽ Best total — Tottenham/Aston Villa Under 2.5 goals
At some point, Tottenham's attack is going to wake up, but I'm not betting on it happening here. Spurs have failed to score in all four Premier League matches this season, most recently playing out a scoreless draw with Everton.
Aston Villa's attack has shown signs of life outside league play, but this still profiles as a matchup where Tottenham's offensive problems can keep the overall score down.
Spurs don't need to be completely shut out for this Under to cash, either. A 1-0, 1-1, or 2-0 result all gets us there, and Tottenham haven't shown enough going forward for me to expect a shootout.
🎲 Wild card — Fulham/Manchester United draw
Manchester United have shown a much higher attacking ceiling than Fulham, but trusting them away from Old Trafford is another matter.
Fulham went to Anfield last weekend and held Liverpool scoreless before putting three past West Ham in the EFL Cup, giving me enough confidence that they can make this uncomfortable at Craven Cottage.
United have already dropped points against Everton and lost to Manchester City and Hull this season, and Wednesday's collapse against Brighton offered another reminder of their volatility. I don't necessarily want to fade United outright, but at a bigger price, the draw is my favorite way to attack this matchup.
More EPL picks
| Matchup | Pick | Expert |
|---|---|---|
| Brentford vs Chelsea | Chelsea team total Over 1.5 — 54% | Chris Vasile |
| Nottingham Forest vs Coventry City | Coming Soon! | Sam Farley |
| Fulham vs Man United | Coming Soon! | Jason Ence |
EPL schedule, Sept. 18-20
| Matchup | Date | Time (ET) | TV |
|---|---|---|---|
 Brentford vs  Chelsea |
Fri, Sep 18 | 3:00 PM | USA Network |
 Tottenham vs  Aston Villa |
Sat, Sep 19 | 7:30 AM | USA Network |
 Brighton vs  Arsenal |
Sat, Sep 19 | 10:00 AM | USA Network |
 Everton vs  Ipswich Town |
Sat, Sep 19 | 10:00 AM | Peacock |
 Newcastle United vs  Hull City |
Sat, Sep 19 | 10:00 AM | Peacock |
 Nottingham Forest vs  Coventry City |
Sat, Sep 19 | 12:30 PM | NBC/Peacock |
 Bournemouth vs  Liverpool |
Sun, Sep 20 | 9:00 AM | USA Network |
 Leeds United vs  Crystal Palace |
Sun, Sep 20 | 9:00 AM | Peacock |
 Manchester City vs  Sunderland |
Sun, Sep 20 | 9:00 AM | Peacock |
 Fulham vs  Manchester United |
Sun, Sep 20 | 11:30 AM | NBC/Peacock |
EPL 2026-27 winner odds
Odds as of 9-17. Percentages courtesy of Kalshi.
Kalshi is a regulated financial exchange where you trade on real-world event outcomes. Instead of traditional odds, prices are listed as percentages (0-100%), representing the market's estimated probability of an event occurring.
Chris Vasile's outright pick: Chelsea (12%)
At 12%, Chelsea is the first outright that jumped off the board. Manchester City, Liverpool and Manchester United are all navigating managerial changes, while Arsenal faces a completely different challenge after finally ending its title drought. It's one thing to hunt down the league leaders, it's another to be the team everyone is chasing. Chelsea is also starting a new chapter under Xabi Alonso, but I view that as a positive. He transformed Bayer Leverkusen into Bundesliga champions by instilling a clear identity and winning mentality. With Cole Palmer, Estevao, Moises Caicedo forming one of the league's most talented cores, Chelsea has everything it needs to contend for the title. At 10/1, the upside is simply too good to pass up.
Pick made on August 1.
About the Premier League
The English Premier League (EPL) is one of the most popular and competitive soccer leagues in the world, featuring 20 clubs battling across a 38-match season. From perennial contenders such as Arsenal, Manchester City, Liverpool, and Chelsea to newly promoted clubs looking to establish themselves in the top flight, every Matchweek brings a new set of storylines and betting opportunities.
The league's depth and variety of playing styles create plenty of ways to wager beyond simply picking a winner. Bettors can target moneylines, spreads, goal totals, player props, futures, and more, with EPL betting odds available throughout the season.
Premier League betting odds
When it comes to betting lines in the Premier League, there are a few major markets that resonate within English soccer. EPL odds reflect the unpredictability of the league, and although fans love to nibble at the Over/Under totals, most head straight to moneyline markets as their first port of call.
Premier League moneyline
The single most popular bet when it comes to Premier League betting lines. It differs from traditional American sports in that it is a three-way market. You can back a win for Team A, a win for Team B, or back the draw (an option that can offer great value). The moneyline is your starting point when it comes to Premier League odds.
Premier League Over/Under
Within Premier League betting lines the Over/Under for an English soccer game is traditionally set at 2.5 goals. It works as a good gauge for the market, but EPL fans can choose their own Over/Under total. Whisper it quietly, but you can even back Under 0.5 goals and pray for the 0-0.
Premier League opening lines
If you want to get an idea of what other English soccer supporters are thinking, you can always compare Premier League betting lines to that of the opening lines. These are the first set of odds released by bookmakers and can be found on the left side of the odds comparison tool.
Premier League Odds FAQs
Arsenal are the betting favorites to defend their EPL crown in 2027.
Arsenal are the defending champions after winning their first title since 2004.
Under its current construction, Manchester United have won nearly three times more than the next closest team, at 13. Expanding it to include the previous structure, Man United still hold the most first division titles at 20.
Since its new formation in 1992, the Premier League has seen seven different winners.
