MLS Predictions: Moneyline Picks for Every Matchday 4 Game

Jason Ence - Contributor at Covers.com
Jason Ence • Betting Analyst 13+ years betting experience
Updated: Mar 13, 2026 , 07:11 PM ET • 4 min read

Jason Ence breaks down his top moneyline picks for every match on MLS Matchday 4.

New York City FC midfielder Nicolas Fernandez Mercau (7) dribbles during the second half.
Photo By - Reuters Connect. New York City FC midfielder Nicolas Fernandez Mercau (7) dribbles during the second half.

Week 3 of the MLS slate saw some surprising results, but some teams are starting to separate themselves from the pack.

There have only been five draws through the first 44 matches of the MLS campaign. That’s as many stalemates as we saw in the opening weekend of the 2025 season.

With CONCACAF Champions League action already seeing some fixture congestion, I break down why we might see more sharing of the spoils in my free MLS Week 4 moneyline picks.

Read on for our MLS predictions and free betting picks for Week 4 of the campaign. 

Week 3 results: 7-7, -0.97u
MLS SEASON: 24-20, +5.17u

MLS moneyline picks for Matchday 4

Game Pick
Toronto FC Toronto FC vs New York Red Bulls New York Red Bulls Toronto FC +145
Atlanta United Atlanta United FC vs Philadelphia Union Philadelphia Union Draw +250
Columbus Crew SC Columbus Crew SC vs Nashville SC Nashville SC Nashville SC -102
New York City FC New York City FC vs Colorado Rapids Colorado Rapids  New York City FC -172
Cardinals Charlotte FC vs  Inter Miami FC Inter Miami FC Inter Miami FC -105
Orlando City SC Orlando City SC vs vs CF Montreal CF Montreal Orlando City SC -141
Chicago Fire Chicago Fire vs D.C. United D.C. United Draw +300
FC Dallas FC Dallas vs San Jose Earthquakes San Diego FC San Jose Earthquakes  +145
Houston Dynamo Houston Dynamo vs Portland Timbers Portland Timbers Houston Dynamo -102
LA Galaxy LA Galaxy vs Sporting Kansas City Sporting Kansas City LA Galaxy -182
Real Salt Lake Real Salt Lake vs Austin FC Austin FC Real Salt Lake -108
Los Angeles FC LAFC vs Cardinals St. Louis CITY SC Los Angeles FC -294
New England Revolution New England Revolution vs FC Cincinnati FC Cincinnati Draw +260
Vancouver Whitecaps FC Vancouver Whitecaps FC vs Minnesota United FC Minnesota United FC Draw +350
San Jose Earthquakes San Jose Earthquakes vs Seattle Sounders FC Seattle Sounders FC Seattle Sounders FC +130

Odds courtesy of Sports Interaction.

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Toronto FC Toronto FC vs New York Red Bulls New York Red Bulls

Pick: Toronto (+145)

The Red Bulls are entertaining to watch, but quite inconsistent so far. Toronto’s playing at home for the first time, coming off an impressive win at Cincinnati, and Josh Sargent is set to make his debut. I love getting them to win at this price. 

Atlanta United Atlanta United FC vs Philadelphia Union Philadelphia Union

Pick: Draw (+250)

This is a matchup of two bad teams. Atlanta is struggling to defend. Philadelphia can’t score. This feels like a 1-1 stalemate. 

Columbus Crew SC Columbus Crew SC vs Nashville SC Nashville SC

Pick: Nashville (-102)

The Crew are still trying to figure out what kind of team they want to be. Nashville comes in off the back of a hard-fought draw with Inter Miami, but they’ve got Sam Surridge and Hany Mukhtar in attack. They should find success against a Crew side struggling against quality playmakers. 

New York City FC New York City FC vs Colorado Rapids Colorado Rapids 

Pick: NYCFC (-172)

NYCFC’s 5-0 win over Orlando was aided by the early red card to Crepeau, but they were already swarming before the man advantage. They’ve looked quite impressive early on, and Colorado has lost five straight on the road dating back to last August. NYCFC should take all three points behind a lethal counter-attack.

Cardinals Charlotte FC vs  Inter Miami FC Inter Miami FC

Pick: Inter Miami (-105)

Speaking of Miami, they defended fairly well against Nashville with Dayne St. Clair looking like the breakout GK he was a season ago. The creativity in the past two matches has suffered a bit as they’ve solidified that back line, but they should find chances against a Charlotte side that has looked poor when they’ve not held a man advantage. 

Orlando City SC Orlando City SC vs vs CF Montreal CF Montreal

Pick: Orlando (-137)

Maxime Crepeau took an extremely early shower when he lost track of where he was, and a 5-0 defeat cost Oscar Pareja his job. Reports indicate he had lost the locker room, and this Orlando team has too much attacking power to keep losing. I like the Lions to get a new-manager bump against a Montreal side with a very shaky defense. 

Chicago Fire Chicago Fire vs D.C. United D.C. United

Pick: Draw (+300)

DC United actually looked solid against Inter Miami, especially on defense. The Fire got a solid draw in Columbus last weekend, but I’ve yet to see anything special. I expect these two defenses to cancel each other out. 

FC Dallas FC Dallas vs San Jose Earthquakes San Diego FC

Pick: San Diego (+145)

I’m getting +145 odds for the better team, and I’m going to take it. FC Dallas has only allowed three goals, but this San Diego attack is lethal when clicking. They’ve managed three straight clean sheet victories to begin the MLS campaign and will get another win on Saturday. 

Houston Dynamo Houston Dynamo vs Portland Timbers Portland Timbers

Pick: Houston (-102)

The Dynamo come in off a week of rest, and are facing a Portland side coming off consecutive defeats. The Timbers coughed up four goals to Vancouver, and Guilherme is the kind of playmaker who is giving them fits. He will lift the Dynamo to victory.

LA Galaxy LA Galaxy vs Sporting Kansas City Sporting Kansas City

Pick: LA Galaxy (-182)

This is a tricky spot for the Galaxy. Gabriel Pec is suspended, while Joseph Paintsil is out for a few weeks after picking up an injury in the defeat to the Rapids. But they still have enough firepower to get the job done against a bad Sporting side that hasn’t taken an away point since last Fourth of July. 

Real Salt Lake Real Salt Lake vs Austin FC Austin FC

Pick: Real Salt Lake (-108)

It’s time to take notice of the youth movement in Utah. Real Salt Lake has handed the reins to Zavier Gozo and Aiden Hezarkhani, and they’ve now terrorized the left-sided defenses of both Seattle and Atlanta. They’ve offset the absence of Diego Luna, and will cause issues for this Austin team that is struggling without Brandon Vazquez and Owen Wolff. 

Los Angeles FC LAFC vs Cardinals St. Louis CITY SC

Pick: LAFC (-294)

Consecutive defeats to San Diego and the Sounders have St Louis sitting with just one point. Things get no easier against an LAFC side that has established itself as perhaps the team to beat in the league. They’re not creating enough scoring chances, and this LAFC attack could put them to the sword. 

New England Revolution New England Revolution vs FC Cincinnati FC Cincinnati

Pick: Draw (+260)

Cincinnati’s attack finally showed up against Tigres in CONCACAF on Thursday night, but Evander is still not ready to play a full match. They’re a better side than New England, but the Revs have had a week off and weren’t awful against the Red Bulls. They’ll play compact and frustrate a Cincy side that hasn’t scored in their last two MLS outings.

Vancouver Whitecaps FC Vancouver Whitecaps FC vs Minnesota United FC Minnesota United FC

Pick: Vancouver (-204)

Vancouver’s midfield may be the best in the league, but their 3-0 loss to Seattle in CONCACAF Champions League on Thursday night was eye-opening. But this Minnesota defense has shown serious flaws, and the Whitecaps still have a lethal attack. A draw wouldn’t shock me, but I think Vancouver gets the job done. 

San Jose Earthquakes San Jose Earthquakes vs Seattle Sounders FC Seattle Sounders FC

Pick: San Jose (+130)

The Sounders have looked great early on, but traveling to St. Louis last weekend, Vancouver on Thursday, and then to San Jose will take a bit of a toll. San Jose has yet to concede a goal, and Timo Werner may get his first start with how well he’s already settling in. His pace will cause issues for a tired Seattle defense. 

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Jason Ence - Covers
Betting Analyst

Jason has been hooked on football since watching Real Madrid and Manchester United in the 2003 Champions League, and has been betting on the sport for nearly 15 years. He has given soccer gambling and fantasy advice for nearly a decade, writing for sites including Rotowire, SB Nation, and The TwinSpires Edge.

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