NFL Week 7 Picks: ChatGPT Predicts the Winner of Every Game

The notion of "any given Sunday" has never been more evident than during the 2025 NFL season.

Not a single unbeaten team remains after six weeks, and many teams that entered the year with Super Bowl aspirations are struggling just to keep their heads above water in their own divisions.

Picking winners has never been more challenging, which is why we've turned to artificial intelligence.

Using the Week 7 moneyline odds from FanDuel, we asked ChatGPT to pick the straight-up winners of every single game on the schedule from the opening whistle on Thursday night to the final play on Monday.

Here’s how the AI sees Week 7 shaking out with its NFL picks. 

Week 7 NFL moneyline picks

Matchup	Pick
Steelers vs Bengals	-240
Rams vs Jaguars	-148
Patriots vs Titans	-360
Saints vs Bears	-245
Dolphins vs Browns	-156
Panthers vs Jets	-124
Eagles vs Vikings	-126
Raiders vs Chiefs	-720
Giants vs Broncos	-340
Colts vs Chargers	-126
Commanders vs Cowboys	-126
Packers vs Cardinals	-310
Falcons vs 49ers	-126
Buccaneers vs  Lions	-275
Texans vs Seahawks	-174

Lines courtesy of FanDuel.

Steelers vs Bengals: Steelers (-240)

Pittsburgh’s price implies strong confidence even on the road, and the matchup profiles as a defensive slugfest where the more stable operation wins close. On a short week, we default to the side with the cleaner turnover profile and special-teams edge, and that aligns with the favored Steelers at this number.

Read our full Steelers vs. Bengals predictions.

Rams vs Jaguars: Rams (-148)

Neutral-site London games often compress variance. The Rams are priced as modest favorites and have the more consistent down-to-down offense. If Jacksonville can’t create short fields, L.A.’s red-zone edge should carry. Given the current moneyline, we lean favorite but wouldn’t chase if it balloons.

Patriots vs Titans: Patriots (-360)

The price implies New England wins this more than three times out of four. Tennessee’s path requires explosive plays and red-zone perfection; that’s a tough ask. If you’re backing the dog, you’re betting on chaos. Straight up, we ride with the big favorite.

Saints vs Bears: Bears (-245)

This number suggests Chicago’s run-pass balance and home field are real factors. In a likely windy Soldier Field game, the Bears’ ability to finish drives tips the scale. As a steep favorite, the moneyline isn’t for the faint of heart, but the market’s confidence is clear. 

Dolphins vs Browns: Browns (-156)

Cleveland is priced as a small home favorite in a projected low-total grinder. In that script, defensive front dominance and field position matter most — both lean Browns. Miami’s speed can break rules, but the market says trench play rules the day on the lakefront. 

Panthers vs Jets: Panthers (-124)

This is the tightest moneyline on the board. When the market says “coin flip,” tilt to the side with the steadier early-down offense. Carolina’s slight favoritism reflects that. If the Jets’ defense turns this into a field-goal festival, live markets could matter more than pregame prices. 

Eagles vs Vikings: Eagles (-126)

Short-road-favorite territory. The market expects a one-score game decided by line play and mistake-free QB-ing. Philadelphia’s ability to sustain long drives is the separator in a controlled-environment matchup. If price flips toward pick’em, the lean remains Philly.

Raiders vs Chiefs: Chiefs (-720)

Massive moneyline favorites are rarely bettable straight up, but they’re also rarely wrong. Kansas City’s passing efficiency and situational mastery (third downs, two-minute) justify the number. Upsets happen, but you don’t need to overthink this one.

Giants vs Broncos: Broncos (-340)

Altitude, travel, and Denver’s defense point to a low-scoring home win. The price is rich, so it’s a parlay piece more than a solo bet, but straight-up the market is decisive. If Denver jumps early, expect a run-heavy script to sit on the lead.

Colts vs Chargers: Chargers (-126)

L.A.’s slight favorite tag reflects trust in their passing ceiling at home. The Colts’ path is pressure and explosives; if those don’t show, efficiency wins for the Bolts. As a moneyline play, the juice is moderate compared to the 1.5-point spread.

Commanders vs Cowboys: Commanders (-126)

Yes, the home team is the underdog. Washington’s offense has been more balanced and their pace can stress Dallas’ coverage rules. If the Cowboys win the turnover margin, they’ll flip this, but pricing nudges Commanders.

Packers vs Cardinals:  Packers (-300)

Laying more than 3-to-1 on a road team is rarely appealing to bet, but straight-up picks are about win probability, not price. Green Bay’s defensive front vs. Arizona’s protection is the key mismatch the market is pricing in.

Falcons vs 49ers: 49ers (-126)

Short favorites at home in prime time equal archetypal moneyline leg. San Francisco’s run game and yards-after-catch machine tend to travel across game scripts. If the Falcons control possession, this can be tight, but we follow the market lean.

Buccaneers vs Lions: Lions (-275)

Fast track, loud dome, and a Detroit offense the market views as top-tier... hence the heavy price. Tampa Bay’s path is generating short fields and finishing in the red zone; if not, Detroit’s sustained drives should wear this down late.

Texans vs Seahawks: Seahawks (-174)

Seattle’s number bakes in a tough venue and travel for Houston. In a lower-total setting, crowd noise and field position often matter more. That’s Seahawks moneyline logic, even if Texans’ ceiling keeps live-bet windows interesting.

ChatGPT has gone 61-31 so far this season for +24.45 units.

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