The 1-5 Tennessee Titans may have thought firing Brian Callahan would lift the gloom around Nissan Stadium, but the return of former head coach Mike Vrabel and his New England Patriots this weekend will surely just add to the dark clouds.
New England has won four in a row to climb to the top of the AFC East, and my Patriots vs Titans predictions expect Drake Maye to cash in against a vulnerable Tennessee squad.
Find out more in my NFL picks for this October 19 matchup, which has all the makings of a Vrabel revenge game.
Want to make sure Covers shows up often in your Google search results and Discover feed?
Simply click here and add Covers as one of your "source preferences".
Patriots vs Titans prediction
Patriots vs Titans Best bet: Drake Maye Over 1.5 passing TDs (-114)
The Drake Maye hype train has left the station, and there’s no reason to think it’ll slow down in Tennessee this weekend.
Maye led the New England Patriots past the New Orleans Saints in Week 6 with 261 passing yards and three TDs, and he’s now thrown for 2+ scores in four of his last five outings.
Sign me up for at least two passing touchdowns again here.
The variety in the New England receiver room is becoming more apparent every week.
Stefon Diggs was the headline act in the Patriots’ victory over the Buffalo Bills, but it was Kayshon Boutte and DeMario Douglas who stepped up last Sunday, while Hunter Henry continues to be a key target for Maye.
That’s more than enough weapons to hit this Over.
It also helps that the visitors’ rushing attack is stuck in mud, somehow turning 31 carries into just 73 yards against the Saints. So it should be a no-brainer for the Patriots to air it out this weekend, boosting their mark of 244.5 passing yards per game, the sixth-most in the NFL.
Look for the New England defense to provide Maye with excellent field position, too. It could be a long day for interim Tennessee Titans head coach Mike McCoy and QB Cam Ward, with enough three-and-outs to give the Patriots a string of chances in the red zone.
Patriots vs Titans same-game parlay
The Patriots are 3-0 ATS on the road this season, and I expect the visitors to take care of business against a Titans team that’s 2-8 ATS in its past 10 contests and hasn’t covered the spread in any of its last 10 games at Nissan Stadium. New England has the edge on both sides of the ball, and you can be sure that Vrabel will be hungry for a big win.
I’m also taking the Over on TreVeyon Henderson catches. We’re still waiting for the Henderson breakout game, and he won’t get many better opportunities. His receiving work has dropped off since six grabs in Week 1, but don’t be surprised if he’s a bigger part of the playbook here, especially if this turns into a blowout.
Patriots vs Titans SGP
- Drake Maye Over 1.5 passing touchdowns
- New England Patriots -6.5
- TreVeyon Henderson Over 2.5 receptions
Our big-ticket SGP: One Way Traffic!
I’ve already made the case for the Patriots to feast in the red zone, and Kayshon Boutte is a nice anytime TD target after a two-touchdown effort last weekend. He’s caught 18 of his 23 targets this year and can make the Titans pay if they’re too locked in on Diggs and Henry.
Patriots vs Titans SGP
- Drake Maye Over 1.5 passing touchdowns
- New England Patriots -6.5
- TreVeyon Henderson Over 2.5 receptions
- Kayshon Boutte anytime touchdown
Patriots vs Titans odds
- Spread: Patriots -6.5 (-115) | Titans +6.5 (-105)
- Moneyline: Patriots -325 | Titans +260
- Over/Under: Over 42.5 (-105) | Under 42.5 (-115)
More NFL picks and odds from Covers
Patriots vs Titans trend to know
The Patriots are 7-2 ATS in the last nine meetings between these teams. Find more NFL betting trends for Patriots vs. Titans.
How to watch Patriots vs Titans
| Location | Nissan Stadium, Nashville, TN |
| Date | Sunday, October 19, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | CBS |
Patriots vs Titans latest injuries
Patriots vs Titans weather
Monitor gametime conditions with our live NFL weather info and learn how weather impacts NFL betting.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
