The first month of NFL action ends with a spicy slate, including a Thursday nighter in the desert, a Sunday morning tilt in Dublin, heavyweight showdowns late Sunday, and a monstrous Monday doubleheader.
Instead of leaving the picks to the talking heads, we've turned to artificial intelligence. Using the Week 4 moneyline odds from FanDuel, we asked ChatGPT to pick the straight-up winners of every single game on the schedule from the opening whistle on Thursday night to the final play on Monday.
Here’s how the AI sees Week 4 shaking out with its NFL picks.
Week 4 NFL moneyline picks
| Matchup | Pick |
|---|---|
 Seahawks vs  Cardinals |
-116 |
 Vikings vs  Steelers |
-146 |
 Saints vs  Bills |
-1800 |
 Titans vs  Texans |
-335 |
 Browns vs  Lions |
-500 |
 Commanders vs  Falcons |
-116 |
 Eagles vs  Buccaneers |
-194 |
 Panthers vs  Patriots |
-240 |
 Chargers vs  Giants |
-290 |
 Jaguars vs  49ers |
-168 |
 Colts vs  Rams |
-180 |
 Bears vs  Raiders |
-110 |
 Ravens vs  Chiefs |
-146 |
 Packers vs  Cowboys |
+265 |
 Jets vs  Dolphins |
-154 |
 Bengals vs  Broncos |
-355 |
Lines courtesy of FanDuel.
Seahawks vs Cardinals: Seahawks (-116)
Seattle’s defense has been the steadier unit to date, and the market leans its way on the road. With both teams at 2–1 and divisional familiarity high, we’ll side with the slight favorite’s pass rush to swing a few key downs.
Vikings vs Steelers: Vikings (-146)
Neutral-site games add variance, but Minnesota’s offense has flashed the higher ceiling early. With travel equalized and a morning kick, we’ll follow the market’s lean toward the Vikings to land a few more explosive plays.
Saints vs Bills: Bills (-1800)
Buffalo has been one of September’s most efficient teams on both sides, and the price reflects a major gap. Upsets happen, but the Bills’ QB play and depth make them the rightful heavy favorite at home.
Titans vs Texans: Texans (-335)
Houston’s defense has tightened in high-leverage spots, and the offense has enough balance to punish negative scripts for Tennessee. Laying a bigger moneyline is justified by matchup edges.
Browns vs Lions: Lions (-500)
Detroit’s front four and early-down efficiency should stress a Cleveland offense that’s been volatile. At Ford Field, the Lions’ balance sets a high floor.
Commanders vs Falcons: Commanders (-116)
In a near coin-flip, Washington’s front can dictate against a Falcons offense still searching for rhythm. Slight edge to the road side that can win the line of scrimmage.
Eagles vs Buccaneers: Eagles (-194)
Tampa has been sticky in recent meetings, but Philadelphia’s trenches and red-zone designs tip this toward the visitors. It’s not a layup, yet the price is fair for a better roster.
Panthers vs Patriots: Patriots (-240)
New England’s defense has traveled, and the ground game is good enough to keep the script friendly. Carolina’s margin is thin if it falls behind.
Chargers vs Giants: Chargers (-290)
Los Angeles’ passing game has been steady, and the matchup with New York’s offense favors a comfortable road script if the Bolts avoid giveaways.
Jaguars vs 49ers: 49ers (-168)
San Francisco’s defense is built to limit explosive passes, and the ground game can salt away leads. Jacksonville can make this tricky, but the Niners at home are still the higher-probability side.
Colts vs Rams: Rams (-180)
L.A.’s passing efficiency and red-zone creativity gives it an edge at home. Indy’s been plucky, but the Rams’ skill talent and pass pro make them the right side straight-up.
Bears vs Raiders: Raiders (-110)
With both teams volatile, we’ll lean toward the home team in a near pick’em. If Vegas protects the ball and finishes drives, that’s enough to squeak by.
Ravens vs Chiefs: Ravens (-146)
Arrowhead is daunting, but Baltimore’s run game and defensive speed travel, and the market has nudged toward the visitors. Slight edge to the Ravens to control tempo and field position.
Packers vs Cowboys: Cowboys (+265)
Dallas’ defense at home should dictate against a Green Bay front that’s been up-and-down. The matchup — particularly on third down — favors the Cowboys in prime time.
Jets vs Dolphins: Dolphins (-154)
Miami’s team speed and scripted offense give them multiple outs at home. New York’s defense can muddy things, but the Dolphins’ explosive capability keeps them as worthy favorites.
Bengals vs Broncos: Broncos (-355)
Denver’s defense and altitude advantage are tough for a Bengals offense still searching for consistency. In a positive script, the Broncos’ run game can close the door.
ChatGPT has gone 39-9 so far this season for +26.4 units.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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