Opening NFL Week 15 Odds and Betting Lines: Buffalo -1.5 at New England

After a big win against the Bengals in Week 14, the Bills are slight favorites against the Patriots in Week 15.

Jason Logan: Senior Betting Analyst at Covers
Jason Logan • Senior Betting Analyst
Dec 7, 2025 • 19:36 ET • 4 min read
Opening NFL Week 15 odds
Photo By - Imagn Images. Bills QB Josh Allen (17) runs with the ball in the snow.

Entering the season, the Sunday afternoon clash between the Los Angeles Chargers and Kansas City Chiefs appeared like it would be the premier matchup on the Week 15 slate. And while it may still carry some heft, this year's edition of the Chiefs isn't as intimidating as the dynastic one of years past.

Similarly, the flailing Baltimore Ravens visit the Cincinnati Bengals as slight road favorites, but neither team has lived up to expectations.

Instead, the Buffalo Bills at New England Patriots (+1.5), Detroit Lions at Los Angeles Rams (-4.5), and Green Bay Packers at Denver Broncos (+2.5) are the marquee matches for this go-around, and they'll all be in the books before Sunday Night Football.

Here's a look at the latest NFL Week 15 odds.

NFL odds Week 15

Matchup Spread Moneyline Over/Under
Falcons Falcons
vs
Buccaneers Buccaneers
Buccaneers -5.5 Falcons +210
Buccaneers -255
43.5
Raiders Raiders
vs
Eagles Eagles
Eagles -12.5 Raiders +700
Eagles -1100
38.5
CommandersCommanders
vs
Giants Giants

Giants -2.5 Commanders +116
Giants -136
46.5
Chargers Chargers
vs
Chiefs Chiefs
Chiefs -5.5 Chargers +220
Chiefs -270
44.5
Browns Browns
vs
Bears Bears
Bears -7.5 Browns +340
Bears -430
39.5
Cardinals Cardinals
vs
Texans Texans
Texans -7 Cardinals +290
Texans -360
43.5
Jets Jets
vs
Jaguars Jaguars
Jaguars -11.5 Jets +570
Jaguars -820
41.5
Ravens Ravens
vs
Bengals Bengals
Bengals +2.5 Ravens -146
Bengals +124
52.5
Bills Bills
vs
Patriots Patriots
Patriots +1.5 Bills -116
Patriots -102
49.5
Panthers Panthers
vs
Saints Saints
Saints +2.5 Panthers -144
Saints +122
39.5
Colts Colts
vs
Seahawks Seahawks
Seahawks -10.5 Colts +440
Seahawks -590
43.5
Lions Lions
vs
Rams Rams
Rams -4.5 Lions +180
Rams -215
52.5
Titans Titans
vs
49ers 49ers
49ers -13.5 Titans +830
49ers -1400
44.5
Packers Packers
vs
Broncos Broncos
Broncos +2.5 Packers -136
Broncos +116
41.5
Vikings Vikings
vs
Cowboys Cowboys
Cowboys -6.5 Vikings +260
Cowboys -320
47.5
ROAD Dolphins
vs
Steelers Steelers
Steelers -3.5 Dolphins +166
Steelers -198
43.5

Lines as of 12-7

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Falcons vs Buccaneers odds (Thursday, 8:15 p.m. ET, Prime)

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Raiders vs Eagles odds (Sunday, 1:00 p.m. ET, FOX)

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Commanders vs Giants odds (Sunday, 1:00 p.m. ET, FOX)

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Chargers vs Chiefs odds (Sunday, 1:00 p.m. ET, CBS)

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Browns vs Bears odds (Sunday, 1:00 p.m. ET, FOX)

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Cardinals vs Texans odds (Sunday, 1:00 p.m. ET, FOX)

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Jets vs Jaguars odds (Sunday, 1:00 p.m. ET, CBS)

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Ravens vs Bengals odds (Sunday, 1:00 p.m. ET, CBS)

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Bills vs Patriots odds (Sunday, 1:00 p.m. ET, CBS)

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Panthers vs Saints odds (Sunday, 4:25 p.m. ET, FOX)

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Colts vs Seahawks odds (Sunday, 4:25 p.m. ET, CBS)

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Lions vs Rams odds (Sunday, 4:25 p.m. ET, FOX)

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Titans vs 49ers odds (Sunday, 4:25 p.m. ET, FOX)

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Packers vs Broncos odds (Sunday, 4:25 p.m. ET, FOX)

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Vikings vs Cowboys odds (Sunday, 8:20 p.m. ET, NBC)

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Dolphins vs Steelers odds (Monday, 8:15 p.m. ET, ESPN)

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Best NFL bets this week

Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!

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Jason Logan Senior Industry Analyst Covers.com
Senior Betting Analyst

In his 20 years with Covers, lead NFL betting analyst; has seen it all and bet it all. Through the wild west of early Internet gambling to lobbying for legalized sports betting to our brave new wagering world, Jason has been a consistent source of actionable info and entertainment for squares and sharps alike. Since joining the Covers team back in 2005, he honed his handicapping skills to provide audiences with the most thorough insights, blending traditional capping methods with advanced modelling and predictive analysis. Jason has studied the ins and outs of the sports betting business, learning from some of the most successful gamblers in the industry and the biggest sportsbook operators on the planet. He is under center for Covers during NFL season as our top NFL expert, taking the points in his infamous NFL Underdogs column and representing the Covers Community at the Super Bowl. While he lives for football season, Jasons first love is basketball and that shows in his in-depth NBA, NCAA, and WNBA betting breakdowns. On top of being a mainstay in media from coast to coast; WPIX, PHL17, Fox 5 San Diego, WGNO, TSN, SportsNet, ESPN Radio; he had his analysis featured in USA Today, MSNBC, ESPN, the Wall Street Journal, CBS, Bloomberg, the L.A. Times, the New York Times and other major publications. You can also find JLo stuffing all the top picks and predictions he can into 10 minutes as the host of Covers; flagship podcast, The Sharp 600.

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