The Houston Texans aim to push their winning streak to six games when they host the Arizona Cardinals this afternoon.
Houston’s last three victories came as underdogs against the Bills, Colts, and Chiefs, but the Texans now return home as heavy favorites against the struggling Cardinals.
My Cardinals vs. Texans predictions and NFL picks focus on Nico Collins continuing his hot streak against a poor passing defense.
Cardinals vs Texans prediction
Cardinals vs Texans Best bet: Nico Collins Over 74.5 receiving yards (-114)
Nico Collins is far and away the top wide receiver for the Houston Texans. He leads the Texans with 61 catches on 103 targets for 916 yards in 12 games, an average of 76.33 yards per contest.
Collins is coming off his third game of at least 100 receiving yards this season, racking up 121 yards on just four catches, including a long of 53. That’s now two straight games and five of his last six in which he’s had at least 75 receiving yards.
The Arizona Cardinals allow 224.3 passing yards per game, and Collins should get his fair share on Sunday afternoon.
Cardinals vs Texans same-game parlay
The Texans should be able to keep this a low-scoring game against the Cardinals while covering the spread.
Houston allows a league-low 16 points per game while scoring just 22 points.
Cardinals vs Texans SGP
- Nico Collins Over 74.5 receiving yards
- Texans -9.5
- Under 42.5
Our big-ticket SGP: Woody Makes His Mark!
I’m adding Collins to score and a Woody Marks touchdown for this big-ticket same-game parlay.
They’re tied for the team lead with five touchdowns each, so we could get a Collins TD in the first half before the Texans turn it over to the running game to close things out.
Cardinals vs Texans SGP
- Nico Collins Over 74.5 receiving yards
- Texans -9.5
- Under 42.5
- Nico Collins anytime touchdown
- Woody Marks anytime touchdown
Cardinals vs Texans game predictions
Cardinals vs Texans moneyline prediction
I can’t see the Cardinals pulling off the upset in Houston. Use the Texans on the moneyline as a parlay piece if you so desire.
Cardinals vs Texans spread prediction
The Cardinals had kept it close in their previous two games before a 45-17 blowout loss to the Rams last week. Meanwhile, Houston boasts one of the best defenses in the league and is coming off a 10-point win over the Chiefs. I’ll take the Texans at -9.5 in what should be an easy home win for Houston.
Cardinals vs Texans Over/Under prediction
Houston has been one of the most profitable underdogs this season at 9-3-1, including going under the total in each of its last four games. The Texans should be able to hold the Cardinals in the low double digits while topping out in the high 20s themselves.
Cardinals vs Texans odds
- Spread: Cardinals +7.5 | Texans -7.5
- Moneyline: Cardinals +300 | Texans -375
- Over/Under: Over 43.5 | Under 43.5
More NFL picks and odds from Covers
Cardinals vs Texans trend to know
The Texans have only cashed the Over in six of their last 22 games for -10.5 units and a -43% ROI. Find more NFL betting trends for Cardinals vs. Texans.
How to watch Cardinals vs Texans
| Location | NRG Stadium, Houston, TX |
| Date | Sunday, December 14, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | FOX |
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