Western Kentucky vs Southern Miss Prediction, Picks & Odds for December 23 — New Orleans Bowl

The Western Kentucky Hilltoppers are a better unit all around than Southern Miss, and they will storm to a victory while covering the modest spread in the New Orleans Bowl.

Jason Ence - Contributor at Covers.com
Jason Ence • Betting Analyst
Dec 22, 2025 • 10:07 ET • 4 min read

NCAAF

Match starts: 25 hrs
USM
34 %
WKU
66 %
EXPERT PICK - SPREAD
Western Kentucky -2.5 (-110) Western Kentucky -2.5 (-110)
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Rodney Tisdale Western Kentucky Hilltoppers NCAA College Football
Photo By - Imagn Images. Western Kentucky QB Rodney Tisdale drops back to pass.

Tuesday’s New Orleans Bowl between Western Kentucky and Southern Miss gives us a unique situation in today’s college football landscape.

Nearly every player on both teams has remained active for the bowl game, meaning we should get a matchup of two hungry sides. But the Golden Eagles will be without head coach Charles Huff, who has taken the Memphis job after just one season in charge.

Find out who I’m backing in my Western Kentucky vs Southern Miss predictions and free college football picks for Tuesday, December 23.

Western Kentucky vs Southern Miss predictions for the New Orleans Bowl

Who will win the New Orleans Bowl?

Western Kentucky will get the win. The Hilltoppers are the more consistent team, especially when it comes to turning drives into points, and their defense is underrated. 

Western Kentucky vs Southern Miss best bet: Western Kentucky -2.5 (-110)

The Western Kentucky Hilltoppers will be without running back La’Vell Wright, who was second on the team in rushing yards and led them with 10 touchdowns. But for an offense that threw the ball at the 17th-highest rate in college football, it might not matter.

The rest of the offense will play in the bowl game, and the Hilltoppers have the luxury of having both Maverick McIvor and Rodney Tisdale available at quarterback. Tisdale took over for the final five games after McIvor suffered a shoulder injury in October.

That means they’ll have options for an offense that ranked 23rd in third-down conversion rate, 32nd in points per quality drive, and 29th in completion rate. The Southern Miss Golden Eagles defense ranked 115th in getting third-down stops, 111th in points per quality drive, and 85th in EPA/dropback. 

While the Golden Eagles also kept most of their roster intact, this is an offense that ranks 110th in dropback success rate and just 59th in points per quality drive. The latter is an area where the Hilltoppers thrive, having allowed the fourth-fewest points per quality drive at just 2.20 on the year. 

The Hilltoppers do a great job of keeping drives alive on third down and getting third-down stops. For Southern Miss, penalties have been a huge problem all season long.

Add in the huge difference in turning quality drives into actual points, and I’ll happily lay less than a field goal for the better team that has gone 9-3 against the spread in its last 12 games.

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Western Kentucky vs Southern Miss same-game parlay

The team totals for this game have Southern Miss at 28.5 points, which is far too high. That said, I don’t think Western will score enough to push the total Over on its own. 

Add in the fact that Western has gone Under in six of its last eight games, and Southern Miss has seen the Under hit in three of four, and you have a perfect spot to fade the total.

Southern Miss didn’t score a single first-quarter point in any of its final three games of the season. Meanwhile, the Hilltoppers led after one period in each of its final three, including a 3-0 lead at LSU.

I expect Western to come out with a strong opening drive that leads to points, while the Golden Eagles once again struggle to find scoring success in the first 15 minutes. 

Western Kentucky vs Southern Miss SGP

  • Western Kentucky -2.5
  • Under 57.5
  • Western Kentucky 1Q -1.5

    Western Kentucky vs Southern Miss odds

    • Spread: Western Kentucky -2.5 (-110) | Southern Miss +2.5 (-110)
    • Moneyline: Western Kentucky -134 | Southern Miss +114
    • Over/Under: Over 58.5 (-110) | Under 58.5 (-110)

    Western Kentucky vs Southern Miss trend to know

    Western Kentucky have covered the Spread in 9 of their last 12 games (+5.70 Units / 43% ROI). Find more college football betting trends for Western Kentucky vs Southern Miss.

    How to watch Western Kentucky vs Southern Miss

    Location Caesars Superdome, New Orleans, LA
    Date Tuesday, December 23, 2025
    Kickoff 5:30 p.m. ET
    TV ESPN

    Western Kentucky vs Southern Miss latest injuries

    Western Kentucky vs Southern Miss weather

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    Odds are correct at the time of publishing and are subject to change.
    Not intended for use in MA.
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    Jason Ence - Covers
    Betting Analyst

    Jason has been hooked on football since watching Real Madrid and Manchester United in the 2003 Champions League, and has been betting on the sport for nearly 15 years. He has given soccer gambling and fantasy advice for nearly a decade, writing for sites including Rotowire, SB Nation, and The TwinSpires Edge.

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