College Football Week 10 Picks: ChatGPT Predicts the Winner of Every Big Game

No. 25 Memphis vs Rice

Moneyline prediction: Memphis (-620)
Odds: Memphis -13.5; total 50.5.

Memphis draws a Friday spotlight with the higher ceiling on both sides of the ball. Rice can move it in spurts, but the Tigers’ offense is more balanced and should create enough explosive plays to separate. With a two-score spread on the board and a hefty moneyline price, a straight-up play favors the ranked team’s depth and special-teams edge. Pick the Tigers.

Penn State vs No. 1 Ohio State

Moneyline prediction: Ohio State (-1600)
Odds: Ohio State -20.5; total 43.5.

This series usually has drama, but the market has made its stance clear with a three-touchdown spread. Penn State’s defense can hold up for stretches, yet Ohio State’s talent advantage across the skill positions and a sturdy front make them the correct moneyline side. In a lower-total game, the favorite’s ability to finish drives looms large. For a straight-up wager, Buckeyes all the way.

No. 9 Vanderbilt vs No. 20 Texas

Moneyline prediction: Texas (-134)
Odds: Texas -2.5; total 45.5.

This number implies a tight one. In coin-flip ranges, we look for the better late-down offense and more trustworthy kicking game; Texas checks those boxes. Vanderbilt’s defense can muddy things, but Texas should create just enough separation with sustained drives and field-position wins. With a short spread and modest total, the moneyline is preferable to laying points.

No. 10 Miami vs SMU

Moneyline prediction: Miami (-465)
Odds: Miami -11.5; total 50.5.

SMU has speed and can stress secondaries, but Miami’s lines are the difference. The Hurricanes’ ability to protect the quarterback and generate steady rushing yards keeps them on schedule and limits the Mustangs’ possession count. In a game priced near two scores, the safer straight-up angle is the ranked team at home with the better trench play.

West Virginia vs No. 22 Houston

Moneyline prediction: Houston (-520)
Odds: Houston -13.5; total 49.5.

West Virginia is pesky, but the Cougars have the better blend of speed and pass-game pop. With double-digit chalk and a total Under 50, this sets up as a control-the-game script for the home side: take a lead, force WVU into longer passing downs, and lean on a defense that stiffens near the red zone. Laying the moneyline price is the safer play.

No. 16 Louisville vs Virginia Tech

Moneyline prediction: Louisville (-430)
Odds: Louisville -11.5; total 53.5.

Louisville’s offense thrives when it avoids self-inflicted mistakes, and Virginia Tech’s road profile suggests fewer margin-for-error opportunities. With the Cardinals favored by double digits, the game plan should skew conservative early, then open up once field position tilts their way. Special teams matter in this range; Louisville holds the edge.

No. 2 Indiana vs Maryland

Moneyline prediction: Indiana (-3500)
Odds: Indiana -21.5; total 50.5.

Indiana projects to control pace and possession, leaning on a defense that squeezes explosive plays and an offense that converts in the red zone. Maryland can land a few shots, but the overall efficiency gap is wide. The market made this a three-score game for a reason.

No. 5 Georgia vs Florida

Moneyline prediction: Georgia (-295)
Odds: Georgia -7.5; total 50.5.

Whether it's neutral-site vibes or true road, Georgia’s front usually dictates outcomes in this rivalry. Florida has playmakers, but consistency has been the issue when drives extend. Georgia’s ability to win the field-position battle and close in the fourth quarter makes the Bulldogs the smart moneyline call. Expect a physical, lower-variance game where the favorite’s depth carries the day.

A reminder for bankroll managers: a -295 favorite with a total around 50 often plays to a lower-variance script. If you’re parlay-averse and prefer single-game exposure, moneyline favorites in this range can be reasonable anchors, just be sure to size your stake appropriately.

No. 12 Notre Dame vs Boston College

Moneyline prediction: Notre Dame (-8000)
Odds: Notre Dame -28.5; total 56.5.

This price says mismatch, and the spread agrees. Notre Dame’s defense should choke off sustained BC drives, forcing the Eagles into long-yardage situations where mistakes follow. The Irish don’t need fireworks, they just need methodical offense and a clean turnover sheet. For straight-up bettors, there’s no reason to get cute: Notre Dame is the pick.

No. 13 Texas Tech vs Kansas State

Moneyline prediction: Texas Tech (-275)
Odds: Texas Tech -7.5; total 53.5.

Both programs can score, but Tech is the more reliable straight-up side with a stronger finishing kick. Kansas State’s path involves winning early downs and stealing a possession; otherwise, Tech’s tempo and depth should wear on the Wildcats late. With a one-score spread and mid-50s total, lay the moneyline price on the ranked team.

No. 15 Virginia vs California

Moneyline prediction: Virginia (-194)
Odds: Virginia -4.5; total 52.5.

Cross-country trips can be tricky, but the Cavaliers own the better two-way profile. Cal’s best shot is to create chaos and win turnover margin; otherwise, Virginia’s balance, especially on third down, should tell. The spread under a touchdown makes the road moneyline reasonable insurance against late-game weirdness. Take Virginia to win outright.

No. 7 Mississippi vs South Carolina

Moneyline prediction: Mississippi (-520)
Odds: Ole Miss -12.5; total 54.5.

South Carolina can threaten vertically, but Mississippi is far more explosive snap-to-snap. When the Rebels are in rhythm, they stack quick scores and force opponents into a pace they don’t want. The market has this around two touchdowns for a reason. With superior firepower, Mississippi on the moneyline is the logical play.

Purdue vs No. 21 Michigan

Moneyline prediction: Michigan (-2000)
Odds: Michigan -20.5; total 49.5.

Expect a steady, workmanlike approach from Michigan: run game, play-action, and a defense that limits chunk plays. Purdue will scrap, but sustained drives will be scarce against this front. In a three-score spread zone, the Wolverines don’t need to be flashy, they just need to be efficient and turnover-free.

No. 8 Georgia Tech vs NC State

Moneyline prediction: Georgia Tech (-200)
Odds: Georgia Tech -5.5; total 57.5.

NC State is feisty at home, but Georgia Tech’s efficiency on early downs and explosive-play potential drive the projection. If the Yellow Jackets avoid penalties and negative plays, they’ll control the script. With a one-score spread and an elevated total, volatility is possible — another reason to prefer the moneyline on the better offense. Georgia Tech to win.

No. 18 Oklahoma vs No. 14 Tennessee

Moneyline prediction: Tennessee (-152)
Odds: Tennessee -3.5; total 56.5.

One of the weekend’s best. Oklahoma brings balance, but Neyland energy plus Tennessee’s pace tilts close games. The Vols have a small edge in finishing drives and special teams, and the market nudges their way. In a toss-up with real shootout potential, we’ll side with the home field and the slightly more consistent red-zone profile.

No. 23 USC vs Nebraska

Moneyline prediction: USC (-225)
Odds: USC -6.5; total 59.5.

This total hints at a track meet. Nebraska’s best avenue is controlling tempo and shrinking possessions; if it turns into a scoring race, USC’s advantages at quarterback and receiver typically shine. The spread sits under a touchdown, making the Trojans a palatable moneyline choice in what could be a tense fourth quarter. Take USC straight-up.

No. 17 Cincinnati vs No. 24 Utah

Moneyline prediction: Utah (-330)
Odds: Utah -8.5; total 55.5.

Utah’s defense routinely shows up in leverage moments. Cincinnati’s path is winning the turnover battle and keeping the chains moving with short third downs. If Utah plays clean, its physicality and situational defense should prevail. At under double-digit chalk, the moneyline is the safer route. Pick Utah straight-up.