No. 16 Florida hosts South Carolina in Week 6 at Ben Hill Griffin Stadium in Gainesville, Florida.
My South Carolina vs. Florida prediction and college football picks have the Gamecocks keeping things competitive this weekend in The Swamp.
Kickoff is scheduled for 12:45 p.m. ET on Saturday, Oct. 10. The Gators are favored by 11.5 points, while the total is set at 59.5.
TOP PICK
Who will win South Carolina vs Florida: South Carolina +11.5
Playable to 48%.
South Carolina is one of the most underrated teams in the market heading into Week 6 following consecutive losses to Alabama and Kentucky.
The final score looked ugly against Alabama in Week 4, but South Carolina was only outgained 489-419 in a tough road matchup. The Gamecocks' day was derailed by a missed field goal, a fumble, an interception, and a pair of failed fourth-down conversion attempts. Their defense also allowed a one-play, 75-yard touchdown drive.
South Carolina outgained Kentucky 458-394 in Week 5 but lost in overtime after once again being burned by turnovers. After jumping out to a 17-0 lead, South Carolina fumbled in its own territory, turned the ball over on downs at midfield, and lost another fumble in the fourth quarter.
COVERS INTEL: South Carolina is 11-10 ATS in SEC road games under head coach Shane Beamer and is due for some positive regression in the turnover department, which should help the Gamecocks keep this Week 6 matchup competitive.
South Carolina vs Florida Over/Under pick: Over 59.5
Playable to 51%.
South Carolina's defense has been gashed repeatedly in matchups against ranked opponents in 2026, allowing 489 yards of total offense to Alabama and 394 yards to Kentucky.
The Gamecocks have been more than capable of holding their own offensively in those games, though. They produced 419 yards of total offense against Alabama and 458 yards against Kentucky. If not for several costly turnovers, South Carolina would have had a legitimate chance to pull off an upset in both games.
Rain and wind could prove troublesome for the offenses on Saturday if the forecast worsens, but as of now, the conditions don't appear to be a major concern.
South Carolina vs Florida combo
Playable to 44%.
The Gamecocks haven't won at Florida since 2014. They are 0-4 SU since then but 2-2 ATS in those games.
South Carolina has the offensive talent to cover a double-digit spread against an underwhelming Florida defense, but there is a big difference between covering a large spread and delivering an outright upset.
Expect South Carolina and Florida to both put points on the board this weekend, but for the Gators to ultimately squeak out a narrow victory at home.
South Carolina vs Florida combo
- Florida moneyline
- Over 59.5
- Top picks: 5-2, +2.59 units
- Combos: 4-5, +2.53 units
South Carolina vs Florida odds
For help understanding probabilities, see our odds calculator.
- Spread: South Carolina +11.5 | Florida -11.5
- Over/Under: Over 59.5 (49%) | Under 59.5 (52%)
- Moneyline: South Carolina 20% | Florida 81%
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South Carolina vs Florida weather
Weather could play a significant role this weekend in Florida, with a high chance of rain and strong winds in the forecast for Saturday.
Check out our college football weather page for up-to-date info on every matchup.
South Carolina vs Florida trend to know
South Carolina has hit the Game Total Over in seven of its last 12 games [+1.50 Units / 11% ROI]. Find more college football betting trends for South Carolina vs. Florida.
How to watch South Carolina vs Florida
| Location | Ben Hill Griffin Stadium, Gainesville, Fla. |
| Date | Saturday, Oct. 10, 2026 |
| Kickoff | 1:45 p.m. ET |
| TV | SEC Network |
South Carolina vs Florida latest injuries
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