College Football Best Bets & Predictions for Week 7 Afternoon Games

College football best bets for Week 7 afternoon games, including Indiana vs. Oregon, Oklahoma vs. Texas, and Iowa State vs. Colorado.

Jared Hochman - Content Operations Manager at Covers.com
Jared Hochman • Content Manager
Oct 11, 2025 • 08:16 ET • 3 min read
College football Week 7 afternoon best bets Arch Manning
Photo By - Imagn Images. Texas Longhorns quarterback Arch Manning (16) runs with the ball.

Week 7's afternoon slate features a pair of big-time showdowns, with Indiana visiting Oregon, while Texas tries to bounce back by hosting Oklahoma in the latest edition of the Red River Rivalry.

We've got a best bet for both of those games, plus a few additional matchups in the late-afternoon time slot — see below for our college football picks and analysis.

College football best bets for Week 7 early games

Game Time (ET)
Network
Best bet
Indiana vs Oregon 3:30 | CBS 1H o27.5
-105
Oklahoma vs Texas 3:30 | ABC Texas Manning o21.5 rush
-114
Iowa State vs Colorado 3:30 | ESPN Colorado +2.5
-105
NC State vs Notre Dame 3:30 | Peacock NC State TT o17.5
-104
TCU vs Kansas State 3:30 | FOX u55.5
-110
Navy vs Temple 4:00 | ESPN2 u54.5
-110

CFB Week 7 preview with Andrew Caley and Douglas Farmer


Indiana vs Oregon best bet

First-half Over 27.5 (-105 at FanDuel)

Oregon has cleared the first-half total in three of its five games this season, the exceptions coming on the shores of Lake Michigan at Northwestern’s temporary stadium (where Unders are a matter of form) and at Penn State in an absolute slugfest.

See our full analysis and Hoosiers/Ducks SGP in our Indiana vs. Oregon predictions.

Oklahoma vs Texas best bet

Arch Manning Over 21.5 rushing yards (-114 at FanDuel)

The Sooners lead the nation in defensive success rate and sack rate. Despite his passing struggles, Arch is still a great athlete and can make things happen with his legs — and he’s going to have to be here as the Sooners might have him running for his life.

See our full analysis and Sooners/Longhorns SGP in our Oklahoma vs. Texas predictions.

Iowa State vs Colorado best bet

Colorado +2.5 (-105 at FanDuel)

Iowa State has some questionable tendencies in its profile and is coming off a poor showing, while Colorado is at home following arguably its two strongest outings of the year.

See our full analysis and Cyclones/Buffaloes SGP in our Iowa State vs. Colorado predictions.

NC State vs Notre Dame best bet

NC State team total Over 17.5 (-104 at FanDuel)

Notre Dame ranks 95th in success rate against the pass and is generating little to no pass rush or havoc. Nobody’s held the Wolfpack below 21 points this season... Notre Dame won’t be the first to do so.

See our full analysis and Wolfpack/Fighting Irish SGP in our NC State vs. Notre Dame predictions.

TCU vs Kansas State best bet

Under 55.5 (-110 at FanDuel)

The wind is expected to be consistently in the double digits throughout the game with gusts up to 25 mph. If the game is going to be dependent on short passes and the run game, then the defenses will be at their best.

See our full analysis and Horned Frogs/Wildcats SGP in our TCU vs. Kansas State predictions.

Under 54.5 (-110 at FanDuel)

The Owls hold up well against the pass, perhaps not something you normally expect to care about against Navy, but very much an explosive concern these days. Removing chunk pass plays from the Midshipmen's quiver will slow this game down and turn it into a more typical slog against a service-academy option attack.

See Douglas' full analysis — and the rest of his best bets — in his college football predictions for Week 7.

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Jared Hochman Content Operations Manager at Covers.com
Content Manager

Before Jared Hochman joined the Covers team in 2020, he worked for newspaper outlets such as the Chronicle Herald and The Coast, worked in marketing for SkipTheDishes and Vivid Seats, and previously ran a magazine. A journalism graduate from the University of King's College in, Halifax, N.S., "Hoch" brings more than a decade of experience in sports betting, having worked as a freelance handicapper, making appearances on Monumental Sports Network and the Sharp 600 podcast, and now also filling in occasionally as host of Covers' NHL Puck Props. 

Awarded Covers' company MVP for 2023, Jared is an avid bettor of MLB, NFL, NHL, and NBA, while also wagering on some soccer and WNBA. His best advice for sports bettors? Price shop, which is something he does daily across 10 different sportsbook apps.

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