College Football Best Bets & Predictions for Week 12 Early Games

College football best bets for Week 12 early games, including Notre Dame vs. Pittsburgh, South Carolina vs. Texas A&M, and Wisconsin vs. Indiana.

Jared Hochman - Content Operations Manager at Covers.com
Jared Hochman • Content Manager
Nov 15, 2025 • 07:59 ET • 3 min read
College football best bets early games Week 12 Will Pauling
Photo By - Imagn Images. Notre Dame wide receiver Will Pauling celebrates getting a first down.

The noon slate for this week's college football schedule is highlighted by a matchup between Notre Dame and Pittsburgh, plus an SEC matchup with Texas A&M hosting South Carolina.

Covers' college football experts have a best bet for both of those games and more — read on for our college football picks and analysis!

College football best bets for Week 12 early games

Game Time (ET)
Network
Best bet
South Carolina vs Pittsburgh 12:00 | ABC South Carolina TT o33.5
-114
South Carolina vs Texas A&M 12:00 | ESPN Texas A&M -18.5
-110
Wisconsin vs Indiana 12:00 | BTN Indiana Mendoza o237.5 pass
-114
Michigan vs Northwestern 12:00 | FOX Northwestern+11.5
-108
Kansas State vs Oklahoma State 12:00 | ESPNU Kansas State-19.5
-108
Arizona vs Cincinnati 12:00 | FS1 Cincinnati-6
-115

CFB Week 12 preview with Andrew Caley and Douglas Farmer


Notre Dame vs Pittsburgh best bet

Notre Dame team total Over 33.5 (-114 at FanDuel)

The Irish score 4.56 points per quality drive, the second-highest rate in the country. The Panthers’ defense ranks No. 120 in the country in that regard. If Notre Dame can get inside Pittsburgh’s 40-yard line just five times, it is reasonable to think that will be enough opportunities for the Irish to clear this team total. And given the Panthers’ pass-heavy offense, Notre Dame should see at least a dozen possessions.

See our full analysis and Fighting Irish/Panthers SGP in our Notre Dame vs. Pittsburgh predictions.

South Carolina vs Texas A&M best bet

Texas A&M -18.5 (-110 at FanDuel)

This feels like a bloodbath. As I have for almost the entire season, I have real questions about this South Carolina offense and how it will find any success against such an elite defense — in a pretty rabid atmosphere.

See our full analysis and Gamecocks/Aggies SGP in our South Carolina vs. Texas A&M predictions.

Wisconsin vs Indiana best bet

Fernando Mendoza Over 237.5 passing yards (-114 at FanDuel)

The Badgers not only have the No. 112 success rate against the pass, but they are also thrown against at the third-highest relative rate in the country. This is a defense begging a Heisman-caliber quarterback to put up a Heisman-worthy stat line.

See our full analysis and Badgers/Hoosiers SGP in our Wisconsin vs. Indiana predictions.

Michigan vs Northwestern best bet

Northwestern +11.5 (-108 at FanDuel)

Michigan has won six of its last seven games, riding a punishing rushing attack that averages 5.8 yards per carry and a defense that holds opponents to 17.2 ppg. That’s a formula that will win a lot of games, but not necessarily one that leads to blowouts: Michigan has only covered in one of its last five games overall, and it has failed to cover four times this season as a double-digit favorite.

See our full analysis and Wolverines/Wildcats SGP in our Michigan vs. Northwestern predictions.

Kansas State vs Oklahoma State best bet

Kansas State -19.5 (-108 at FanDuel)

Kansas State is 4-5 right now, with a trip to Utah remaining before hosting Colorado to end the season. It is all but guaranteed that Chris Klieman emphasized to his team during the idle week that they need a win on Saturday to keep their bowl hopes thriving.

See Douglas' full analysis, and all of his best bets this week, in his college football predictions for Week 12.

Arizona vs Cincinnati best bet

Cincinnati -6 (-115 at FanDuel)

It's a nice buy-low spot for Cincinnati, which is coming off its worst performance of the season, but had a bye week to regroup and faces an Arizona team that is coming off a misleading (and flukey) victory.

See more picks and our college football Week 12 breakdown on the Covers YouTube channel.


Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Jared Hochman Content Operations Manager at Covers.com
Content Manager

Before Jared Hochman joined the Covers team in 2020, he worked for newspaper outlets such as the Chronicle Herald and The Coast, worked in marketing for SkipTheDishes and Vivid Seats, and previously ran a magazine. A journalism graduate from the University of King's College in, Halifax, N.S., "Hoch" brings more than a decade of experience in sports betting, having worked as a freelance handicapper, making appearances on Monumental Sports Network and the Sharp 600 podcast, and now also filling in occasionally as host of Covers' NHL Puck Props. 

Awarded Covers' company MVP for 2023, Jared is an avid bettor of MLB, NFL, NHL, and NBA, while also wagering on some soccer and WNBA. His best advice for sports bettors? Price shop, which is something he does daily across 10 different sportsbook apps.

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