The noon slate for this week's college football schedule is highlighted by a matchup between Notre Dame and Pittsburgh, plus an SEC matchup with Texas A&M hosting South Carolina.
Covers' college football experts have a best bet for both of those games and more — read on for our college football picks and analysis!
College football best bets for Week 12 early games
| Game | Time (ET) Network |
Best bet |
|---|---|---|
| 12:00 | ABC | -114 |
|
| 12:00 | ESPN | -110 |
|
| 12:00 | BTN | -114 |
|
| 12:00 | FOX | -108 |
|
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12:00 | ESPNU | -19.5-108 |
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12:00 | FS1 | -115 |
CFB Week 12 preview with Andrew Caley and Douglas Farmer
LIVE College Football Week 12 Preview with @D_Farmer and Andrew Caley https://t.co/4JiKfJqBfB
— Andrew Caley (@Covers_Caley) November 12, 2025
Notre Dame vs Pittsburgh best bet
Notre Dame team total Over 33.5 (-114 at FanDuel)
The Irish score 4.56 points per quality drive, the second-highest rate in the country. The Panthers’ defense ranks No. 120 in the country in that regard. If Notre Dame can get inside Pittsburgh’s 40-yard line just five times, it is reasonable to think that will be enough opportunities for the Irish to clear this team total. And given the Panthers’ pass-heavy offense, Notre Dame should see at least a dozen possessions.
See our full analysis and Fighting Irish/Panthers SGP in our Notre Dame vs. Pittsburgh predictions.
South Carolina vs Texas A&M best bet
Texas A&M -18.5 (-110 at FanDuel)
This feels like a bloodbath. As I have for almost the entire season, I have real questions about this South Carolina offense and how it will find any success against such an elite defense — in a pretty rabid atmosphere.
See our full analysis and Gamecocks/Aggies SGP in our South Carolina vs. Texas A&M predictions.
Wisconsin vs Indiana best bet
Fernando Mendoza Over 237.5 passing yards (-114 at FanDuel)
The Badgers not only have the No. 112 success rate against the pass, but they are also thrown against at the third-highest relative rate in the country. This is a defense begging a Heisman-caliber quarterback to put up a Heisman-worthy stat line.
See our full analysis and Badgers/Hoosiers SGP in our Wisconsin vs. Indiana predictions.
Michigan vs Northwestern best bet
Northwestern +11.5 (-108 at FanDuel)
Michigan has won six of its last seven games, riding a punishing rushing attack that averages 5.8 yards per carry and a defense that holds opponents to 17.2 ppg. That’s a formula that will win a lot of games, but not necessarily one that leads to blowouts: Michigan has only covered in one of its last five games overall, and it has failed to cover four times this season as a double-digit favorite.
See our full analysis and Wolverines/Wildcats SGP in our Michigan vs. Northwestern predictions.
Kansas State vs Oklahoma State best bet
Kansas State -19.5 (-108 at FanDuel)
Kansas State is 4-5 right now, with a trip to Utah remaining before hosting Colorado to end the season. It is all but guaranteed that Chris Klieman emphasized to his team during the idle week that they need a win on Saturday to keep their bowl hopes thriving.
See Douglas' full analysis, and all of his best bets this week, in his college football predictions for Week 12.
Arizona vs Cincinnati best bet
Cincinnati -6 (-115 at FanDuel)
It's a nice buy-low spot for Cincinnati, which is coming off its worst performance of the season, but had a bye week to regroup and faces an Arizona team that is coming off a misleading (and flukey) victory.
See more picks and our college football Week 12 breakdown on the Covers YouTube channel.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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