Two of the best teams in the Eastern Conference do battle when Cade Cunningham and the Detroit Pistons host James Harden and the Cleveland Cavaliers.
With Cleveland banged up, Detroit is a 6-point home favorite, but my Cavs vs. Pistons predictions break down why the East’s No. 1 seed still deserves more respect.
Read more in my NBA picks for this matchup, set to tip off at 7:00 p.m. ET from Little Caesars Arena in Detroit.
Cavaliers vs Pistons prediction
Cavaliers vs Pistons best bet: Pistons -6 (-110)
It feels like people aren’t giving the Detroit Pistons enough respect. Cade Cunningham and Jaren Duren are stars, and the only team that has a better net rating than the Pistons this season is the Oklahoma City Thunder.
They’ve also been a great team at home this season, going 22-7 with an average margin of victory of 10.3 points.
Meanwhile, the acquisition of James Harden has been a home run for the Cleveland Cavaliers. Unfortunately, he’s questionable to play with a thumb injury while Donovan Mitchell is already out.
That’s too much to overcome against this really great Pistons team.
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Cavaliers vs Pistons same-game parlay
Sure, the James Harden thing has worked for Cleveland so far. But he won’t help the fact that the Cavaliers allow the fifth-most points per game to opposing guards. Give me Cade to go Over 25.5 points, something he’s done in eight of his last 11 games.
The Pistons are also an elite rebounding team, ranking second in rebounding rate. Tobias Harris has hauled down six or more rebounds in seven of his last eight games, and with the Cavs potentially down their top two shooters, there could be plenty of boards up for grabs.
Cavaliers vs Pistons SGP
- Pistons -6
- Cade Cunningham Over 25.5 points
- Tobias Harris Over 5.5 rebounds
Our "from downtown" SGP: Cade!
Cade is getting some MVP buzz down the stretch, and a big game against an East contender could bolster that case.
Cavaliers vs Pistons SGP
- Cade Cunningham Over 25.5 points
- Cade Cunningham Over 5.5 rebounds
- Cade Cunningham Over 9.5 assists
- Cade Cunningham Over 1.5 steals
Cavaliers vs Pistons odds
- Spread: Cavaliers +6 | Pistons -6
- Moneyline: Cavaliers +200 | Pistons -240
- Over/Under: Over 227 | Under 227
Cavaliers vs Pistons betting trend to know
The Pistons have covered the 1H spread in 28 of their last 45 games (+10.75 Units / 21% ROI). Find more NBA betting trends for Cavaliers vs. Pistons.
How to watch Cavaliers vs Pistons
| Location | Little Caesars Arena, Detroit, MI |
| Date | Friday, February 27, 2026 |
| Tip-off | 7:00 p.m. ET |
| TV | ESPN |
Cavaliers vs Pistons latest injuries
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