Opening Day in the Majors brings a marquee matchup in San Francisco, but this one sets up as a difficult spot for the Giants against a pitcher they struggled to handle all last season.
With Max Fried on the mound and San Francisco’s well-documented issues against left-handed pitching, my Yankees vs. Giants predictions and MLB picks expect New York to create separation, making the runline a strong play for Wednesday, March 25.
Yankees vs Giants predictions
Yankees vs Giants best bet: Yankees -1.5 (+136)
The 2026 MLB season begins with two aces toeing the rubber, with Max Fried facing off against Logan Webb.
The New York Yankees ace will be a problem for a San Francisco Giants lineup that struggled against left-handed pitchers last season.
Fried is coming off a year where he owned a 3.38 xERA while the Giants had the third-worst wRC+ and were dead last in OPS against lefties, and didn’t do much to address that in the offseason.
I love backing slight road favorites on the runline at plus money, and the Yanks have plenty of value on Opening Day.
COVERS INTEL: Logan Webb is the Giants' ace, but he was hit hard and often last season, ranking in the 38th percentile or worse in expected batting average and average exit velocity.
Yankees vs Giants same-game parlay (SGP)
Aaron Judge is coming off his third MVP season in the last four years, where he led the majors in batting average, slugging, and OPS while swatting 53 dingers and 114 RBIs.
Simply put, he’s one of the greatest hitters of all time and has a solid track record against Giants’ starter Logan Webb (more on that later).
Another guy with good numbers against Webb is third baseman Ryan McMahon from his time with the Colorado Rockies. McMahon has a career .310 expected batting average in 46 career plate appearances vs. Webb.
Yankees vs Giants SGP
- Yankees -1.5
- Aaron Judge Over 2.5 H/R/R
- Ryan McMahon Over 1.5 H/R/R
Yankees vs Giants home run pick: Aaron Judge (+250)
All rise!
There’s no other place we should start the season with our home run bets than with the greatest home run hitter of this generation.
Judge has whacked 210 dingers over the last four seasons, including 53 last season.
So, of course, the three-time MVP has great numbers vs. Webb. He’s 3-for-7 with two homers in his career vs. Webb, who has been prone to giving up hard contact.
It would be cool to see Judge plunk one in McCovey Cove on Opening Day.
- Best bets: 0-0, +0.0 units
- SGPs: 0-0, +0.0 units
- HR picks: 0-0, +0.0 units
Yankees vs Giants odds
- Moneyline: New York -124 | San Francisco +106
- Run line: New York -1.5 (-136) | San Francisco +1.5 (-176)
- Over/Under: Over 7.0 | Under 7.0
Yankees vs Giants trend
The Yankees hit the Team Total Over in 18 of their last 23 away games last season for +12.40 Units and a 46% ROI. Find more MLB betting trends for Yankees vs. Giants.
How to watch Yankees vs Giants and game info
| Location | Oracle Park, San Francisco, CA |
| Date | Wednesday, March 25, 2026 |
| First pitch | 8:05 p.m. ET |
| TV | Netflix |
| Yankees starting pitcher | Max Fried (0-0, 0.00 ERA) |
| Giants starting pitcher | Logan Webb (0-0, 0.00 ERA) |
Yankees vs Giants latest injuries
Yankees vs Giants weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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