After getting lit up last night by the Chicago Cubs, I expect the Tigers to come out with a chip on their shoulder this evening.
My Tigers vs. Cubs predictions and MLB picks for Wednesday, July 22, see Detroit pulling off the upset on the road.
Who will win Tigers vs Cubs today: Tigers moneyline (+111)
There is no way I can ignore the Chicago Cubs scoring 11 runs last night and not take the Detroit Tigers tonight, especially with them drawing Colin Rea.
The Cubs right hander has been brutal all season, and over his last three starts, he owns a 4.41 ERA, 4.87 xERA, and 1.47 WHIP.
I think the top of the Tigers lineup can hold it down, even with most of the offense going cold lately. Asking the Cubs to replicate last night's success at the plate is a lot to ask for, especially after seeing several teams go cold following a 10+ run performance the day before.
Give me the Tigers.
COVERS INTEL: Tigers right hander Keider Montero owns a 2.29 xERA and 1.13 WHIP over his last three starts, while allowing a 0% barrel rate during that stretch.
Tigers vs Cubs Over/Under pick: Over 7.5 (-125)
Typically, a team coming off a ten-plus run outburst suggests a natural offensive regression that favors the Under, but tonight’s matchup presents a prime spot to shatter that.
Standing in the way of a quiet evening is Colin Rea, whose recent outings have featured an alarmingly high WHIP and elevated home run rate. Throwing hittable, middle-middle pitches to a Detroit lineup primed to bounce back makes a low-scoring affair unlikely.
With Rea vulnerable to hard contact and the Chicago bats already in a groove, expect early offensive fireworks to push this game over the 7.5 total with ease.
- 2026 MLB Season: 328-607, +1.60 Units
Tigers vs Cubs weather
It is looking like a mild evening on the Northside of Chicago, with the wind lightly blowing in and temperatures sitting in the sub 70s.
Tigers vs Cubs odds
- Moneyline: Detroit +111 | Chicago -113
- Run line: Detroit +1.5 (-199) | Chicago -1.5 (+194)
- Over/Under: Over 7.5 (-117 | Under 7.5 (+115)
Tigers vs Cubs trend
The Detroit Tigers have hit the Run Line in 21 of their last 40 games (+5.65 Units / 12% ROI). Find more MLB betting trends for Tigers vs. Cubs.
How to watch Tigers vs Cubs and game info
| Location | Wrigley Field, Chicago, IL |
| Date | Wednesday, July 22, 2026 |
| First pitch | 8:10 p.m. ET |
| TV | ESPN |
| Tigers starting pitcher | Keider Montero (6-5, 3.22 ERA) |
| Cubs starting pitcher | Colin Rea (7-6, 4.74 ERA) |
Tigers vs Cubs latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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