The St. Louis Cardinals will look to clinch just their second series win in two weeks when they host the Cincinnati Reds in the second game of their weekend series.
Nothing gets Cardinal bats started like playing Cincinnati, and St. Louis hopes to keep the hitting going on Saturday.
The Reds are in danger of losing their third series in a row, and with the Cardinals having an edge in the pitching matchup, my Reds vs. Cardinals predictions and MLB picks call for St. Louis to get the win.
Who will win Reds vs Cardinals today: Cardinals -1.5 run line (+165)
The St. Louis Cardinals have scored 24 runs in three games against the Cincinnati Reds this season. Jordan Walker, in particular, loves seeing the Reds, hitting .500 with five extra-base hits and eight RBIs.
Reds starter Nick Lodolo doesn't seem like a candidate to slow the St. Louis onslaught. Lodolo's fastball is in the bottom 5% of MLB, and his barrel rate allowed is in the bottom 2%. His barrel rate (14.3%) nearly matches his strikeout rate (18.3%).
The Cards' last three wins have been by multiple runs. I'd take them and give the runs until about +150, or until the moneyline gets closer to -110.
COVERS INTEL: Lodolo throws his sinker nearly 23% of the time, even though batters are slugging 1.000 against it with a .444 average. He's given up almost as many extra base hits on the sinker (8) as swings and misses (9).
Reds vs Cardinals Over/Under pick: Under 9.5 (-122)
The total market is teetering on the verge of being too expensive. I'd prefer a cutoff at a run lower and closer to even odds, but I'll take -122. Not much steeper.
St. Louis has allowed under five runs in four of the last five. Cincinnati doesn't have much punch with Elly de la Cruz hurt. The Reds have lost six of eight, hitting the five-run mark once. They're scoring less than three a game with Elly out.
Cards starter Matthew Liberatore is coming off a scoreless 5.1 innings. He dropped his ERA by .77 runs and his WHIP by .096 in May.
- ML/RL bets: 19-23 -2.79 units
- Over/Under bets: 23-23 -1.51 units
Reds vs Cardinals odds
- Moneyline: Reds +117 | Cardinals -122
- Run line: Reds +1.5 (-178) | Cardinals -1.5 (+170)
- Over/Under: Over 9.5 (+117) | Under 9.5 (-122)
Reds vs Cardinals trend
The St. Louis Cardinals have covered the Run Line in 30 of their last 45 games (+9.25 Units / 14% ROI. Find more MLB betting trends for Reds vs. Cardinals.
How to watch Reds vs Cardinals and game info
| Location | Busch Stadium, St. Louis, MO |
| Date | Saturday, June 6, 2026 |
| First pitch | 2:15 p.m. ET |
| TV | Reds.TV, Cardinals.TV |
| Reds starting pitcher | Nick Lodolo (2-1, 5.20 ERA) |
| Cardinals starting pitcher | Matthew Liberatore (3-3, 4.35 ERA) |
Reds vs Cardinals latest injuries
Reds vs Cardinals weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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