Orioles vs Red Sox Prediction, Picks & Best Bet for Today’s MLB Game 1

Ponnaiya's pick: The conditions are conducive to the Over as the Orioles and Red Sox collide for Game 1 of a doubleheader on Friday afternoon.

Rohit Ponnaiya - Betting Analyst at Covers.com
Rohit Ponnaiya • Betting Analyst
May 23, 2025 • 09:05 ET • 4 min read
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This article contains predictions for an old game!

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Ryan O'Hearn Baltimore Orioles MLB
Photo By - Imagn Images. Ryan O'Hearn of the Baltimore Orioles in MLB action.

Last night's scheduled game between the Baltimore Orioles and Boston Red Sox was rained out and will take place on Friday afternoon as the first game in a double-header. 

Boston has swapped pitchers from Lucas Giolito to Brayan Bello, and that along with a change in the wind in Beantown has me backing the Over in my Orioles vs. Red Sox predictions.

Here are my free MLB picks for this AL East showdown on May 23, with the first pitch scheduled for 1:35 p.m. ET at Fenway Park.

Orioles vs Red Sox prediction

My Orioles vs Red Sox best bet: Over 9 (-120 at Sports Interaction)

The Boston Red Sox were going to start Lucas Giolito yesterday but have decided to move him to tonight's contest, with Brayan Bello getting the nod the early game. The right-hander is in the bottom 10th percentile in expected ERA (5.59) and expected batting average (.302)

The Baltimore Orioles respond with lefty Cade Povich, who has a 5.23 ERA with an xERA of 5.84 across eight starts. 

The Red Sox are seventh in the majors in OPS (.743) with that number ticking up to .776 against southpaws. The Orioles have struggled to hit lefties, but have been productive against righties like Bello, posting an OPS of .735.

Both lineups strike out at extremely high rates but when they make contact, they crush the ball. The O's are seventh in barrel rate, and fourth in exit velocity and hard-hit rate. The BoSox are in the Top-3 in all three of those metrics.

Given that neither starting pitcher generate many whiffs, we should see plenty of offense. In addition, while we had 20 mph winds blowing towards the infield last night, it's now projected at 9 mph towards the outfield.

Orioles vs Red Sox same-game parlay (SGP)

Over 9

Ryan O'Hearn 1+ hits

Rafael Devers Over 0.5 walks

Ryan O'Hearn leads Baltimore with a batting average of .306 and his xBA of .305, indicates that number is sustainable long-term. He's batting .323 this month and will have the platoon advantage against Bello.

Povich has walked 11 batters over his last five starts, and Baltimore's relievers have really struggled with control (91 walks through 182 2/3 innings). Rafael Devers is tied for second in the majors in walks (39) and has been given a free pass in 12 of his last 16 games.

Orioles vs Red Sox odds

Orioles vs Red Sox live odds

Orioles vs Red Sox opening odds

  • Moneyline: Baltimore +105 | Boston -125
  • Run line: Baltimore +1.5 (-200) | Boston -1.5 (+165)
  • Over/Under: Over 8.5 (-120) | Under 8.5 (+100)

Orioles vs Red Sox trend

The Orioles are 1-8 in their last nine games. Find more MLB betting trends for Orioles vs. Red Sox.

How to watch Orioles vs Red Sox and game info

Location Fenway Park, Boston, MA
Date Friday, 5-23-2025
First pitch 1:35 p.m. ET
TV MASN, NESN
Orioles starting pitcher Cade Povich
(1-3, 5.23 ERA)
Red Sox starting pitcher Brayan Bello
(2-1, 4.02 ERA)

Orioles vs Red Sox latest injuries

Orioles vs Red Sox weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Betting Analyst

With a background playing soccer, rugby, and boxing, combined with a journalism degree, it's little surprise that Rohit gravitated towards the world of sports betting. He specializes in betting on UFC and college basketball, two sports where the eyeball test can tell you a lot more about matchups than any analytics. Rohit has years of experience handicapping NFL and NBA games as well as niche betting markets such as politics and Oscar odds. He's also the resident CFL expert and formerly hosted "The Chez and Ro Show" with former CFL star Davis Sanchez.

You can catch Rohit breaking down every UFC event with Joe Osborne on "P4P Picks" on the Covers YouTube channel and he also has regular appearances on "Before You Bet" with Joe. In addition, he's a regular guest on "By The Book" on the Monumental Sports Network and makes guest appearances on VSIN's "The Handle" and CBS Sports.

Rohit primarily makes his bets at bet365, which offers a wide variety of prop markets, but also has accounts at several others so he can shop around for the best prices. For Rohit, bankroll management is key. He believes you should never bet what you can't afford to lose and maximize those few betting opportunities where books misprice a line.

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