The St. Louis Cardinals look to even their series when they host the Cleveland Guardians tonight at Busch Stadium.
Cleveland starter Joey Cantillo has command issues, and my Guardians vs. Cardinals predictions expect St. Louis to come out on top.
Read on for my MLB picks for Tuesday, April 14.
Who will win Guardians vs Cardinals today: Cardinals moneyline (+105)
Michael McGreevy's underlying metrics aren't pretty, but he doesn't need to be dominant tonight.
He just needs to survive long enough for the St. Louis Cardinals to make Cleveland Guardians starter Joey Cantillo pay.
Cantillo walks over four batters per nine with a 45% fly ball rate, and that’s a dangerous combination for a lefty on a warm night with gusty winds blowing out to left.
Cleveland's bullpen is surrendering 1.61 home runs per nine, and while their bats boomed last night, the Guardians average a shade under four runs per night.
Back the home dog tonight.
COVERS INTEL: Joey Cantillo is surrendering a .361 slugging percentage and .342 wOBA against right-handed hitters this season. 
Guardians vs Cardinals Over/Under pick: Over 8.5 (+100)
Neither bullpen can consistently get anyone out, and that's a problem against two lineups that rank seventh and eighth in expected offensive production despite sitting outside the Top 15 in actual results.
McGreevy's underlying metrics suggest Cleveland will score, while Cantillo's command issues against a right-handed heavy Cardinals lineup and gusty winds blowing out mean a few free passes could turn into a run explosion in a hurry.
Cleveland's bullpen is surrendering 1.61 home runs per nine. The Cardinals' pen can't miss bats. Play the Over.
- ML/RL bets: 1-3, -1.90 units
- Over/Under bets: 2-1, +0.94 units
Guardians vs Cardinals odds
- Moneyline: Guardians -104 | Cardinals -104
- Run line: Guardians -1.5 (+133) | Cardinals +1.5 (-186)
- Over/Under: Over 8.5 (-117) | Under 8.5 (-117)
Guardians vs Cardinals trend
The Over is 4-1 in Cleveland’s previous five games. Find more MLB betting trends for Guardians vs. Cardinals.
How to watch Guardians vs Cardinals and game info
| Location | Busch Stadium, St. Louis, MO |
| Date | Tuesday, April 14, 2026 |
| First pitch | 7:45 p.m. ET |
| TV | CleGuardians.TV, Cardinals.TV |
| Guardians starting pitcher | Joey Cantillo (1-0, 2.46 ERA) |
| Cardinals starting pitcher | Michael McGreevy (1-1, 2.16 ERA) |
Guardians vs Cardinals latest injuries
Guardians vs Cardinals weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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