The Houston Astros seek a series victory this afternoon when they host the Los Angeles Dodgers at Daikin Park.
The L.A. bats have struggled recently, and my Dodgers vs. Astros predictions have Houston winning this series.
Read on for my MLB picks for Wednesday, May 6.
Who will win Dodgers vs Astros today: Astros moneyline (+180)
Lance McCullers Jr. is trending up at exactly the right time, generating 13 swings and misses across six innings against Baltimore last week.
The Houston Astros have also been the hotter offense over the last seven days, posting a 107 wRC+ while the Los Angeles Dodgers rank 14th with just two home runs and a .085 ISO.
Yordan Alvarez is a threat against anyone, and Jose Altuve has gone deep twice against Dodgers starter Tyler Glasnow.
Nearly 2/1 underdogs with an offense this dangerous is too much to pass up.
COVERS INTEL: Alvarez ranks in the 89th percentile, with a 51.3% hard-hit rate across 117 batted-ball events. 
Dodgers vs Astros Over/Under pick: Over 8.5 (-112)
Glasnow is excellent but has surrendered four home runs this season, and the wind blowing out at Daikin Park on a hot, humid afternoon turns warning-track shots into runs.
The Astros bullpen ranks among the worst in baseball over the last seven days, posting a 5.88 ERA with a 15% home run rate.
Alvarez is a genuine threat to go deep against anyone, and once both starters exit, neither pen inspires confidence.
The Over is 6-4 in their previous 10 meetings, and this total is begging to be cleared.
- ML/RL bets: 5-9, -3.05 units
- Over/Under bets: 5-7, -3.16 units
Dodgers vs Astros odds
- Moneyline: Dodgers -194 | Astros +186
- Run line: Dodgers -1.5 (-117) | Astros +1.5 (+113)
- Over/Under: Over 8.5 (-117) | Under 8.5 (+108)
Dodgers vs Astros trend
The Astros are 7-3 in their previous 10 games with the Dodgers. Find more MLB betting trends for Dodgers vs. Astros.
How to watch Dodgers vs Astros and game info
| Location | Daikin Park, Houston, TX |
| Date | Wednesday, May 6, 2026 |
| First pitch | 2:10 p.m. ET |
| TV | SportsNet LA, SCHN |
| Dodgers starting pitcher | Tyler Glasnow (3-0, 2.56 ERA) |
| Astros starting pitcher | Lance McCullers Jr. (2-2, 6.32 ERA) |
Dodgers vs Astros latest injuries
Dodgers vs Astros weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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