Brewers vs Diamondbacks Picks and Predictions: Desert 'Dogs Are Live Today

Arizona is a big dog today against Brandon Woodruff and the Brewers. But as some D-backs have had success against the Milwaukee righty before — and the Brew Crew struggle against lefties like Caleb Smith — we like the value on the home team in the desert.

Zachary Cohen
Posted: Jun 23, 2021 9:55 AM ET Updated: Jun 23, 2021 11:50 AM ET Est Time: 4 min
Nick Ahmed Arizona Diamondbacks MLB
Photo By - USA TODAY Sports

The Arizona Diamondbacks will host the Milwaukee Brewers at 3:40 p.m. ET as the two clubs clash at Chase Field in Phoenix, Arizona.

The D-backs are big MLB betting underdogs this afternoon but, believe it or not, the Diamondbacks have a chance to steal this series with a win today.

They'll be in tough against one of Milwaukee's aces — can Arizona win and potentially start putting together some more victories? Find out in our Brewers vs. Diamondbacks picks and predictions for Wednesday, June 23.

Brewers vs Diamondbacks game info

Location: Chase Field, Phoenix, AZ
Date: Wednesday, June 23, 2021
Time: 3:40 p.m. ET
TV: Bally Sports Arizona, Bally Sports Wisconsin

Brewers vs Diamondbacks odds

Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.

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MLB sharp money and line movement report

By Patrick Everson

As of 11:45 a.m. ET today, Milwaukee is a -220 favorite at DraftKings, shooting up from its Tuesday night opener of -177. Early practically all Brewers early, with 92 percent of moneyline bets and 95 percent of moneyline dollars on Milwaukee. The total fell from 8 (Under -115) to 7.5 flat (-110), with 71 percent of tickets on the Over, but 68 percent of dollars on the Under.

Check out the full line movement for this game

Brewers vs Diamondbacks betting preview

Starting pitchers

Brandon Woodruff (5-3, 1.94 ERA): Woodruff gave up five earned runs in five innings against the Colorado Rockies last game but he deserves a break with that game being played at Coors Field. Heading into that one, the righty had allowed two or fewer earned runs in 12 games in a row. He is missing bats at an incredible rate and it won’t take long for him to get back in the win column.

Caleb Smith (2-2, 3.21 ERA): Smith faced this Milwaukee team back on June 6, when he gave up just one earned run in five innings. The lefty struck out eight batters in that game, and he should be pretty confident coming into this one. Smith was excellent his last time on the mound as well, when he threw six shutout innings against the Los Angeles Dodgers.


Be sure to monitor the gametime conditions with our MLB weather info.

Key injuries

Brewers: Corey Dickerson OF (Out), Travis Shaw 3B (Out), Lorenzo Cain OF (Out).
Diamondbacks: Ketel Marte OF (Questionable), Eduardo Escobar 3B (Questionable), Carson Kelly C (Out), Kole Calhoun OF (Out).
Find our latest MLB injury reports.

Betting trend to know

The Brewers are 2-6 in their last eight games. Find more MLB betting trends for Brewers vs. Diamondbacks.

Moneyline pick

The Brewers are batting just .218 against left-handed pitchers this season, and they’re also missing Lorenzo Cain, who has made a career being an absolute monster against southpaws. This matchup is just an extremely tough one for Milwaukee, which just so happens to be a massive favorite in this game.

The Brewers obviously have a good chance of winning this game, but so do the Diamondbacks — that’s what makes them such an enticing underdog this afternoon.

Woodruff is a legitimate Cy Young candidate this season but some of these Arizona hitters have had their way with Woodruff in the past. Eduardo Escobar is 3 for 5 with an RBI against the righty, and Josh Rojas hit a homer off him in their last matchup.

If those two can come through for the Diamondbacks, that just might be enough in what should be a low-scoring game. And of course, Ketel Marte and David Peralta are always capable of giving Arizona big games, so the two of them are going to be players to watch as well.

PREDICTION: Diamondbacks ML (+172)

Over/Under pick

This series hasn’t featured a whole lot of scoring, as the two teams combined to score six runs in the series opener and then followed it up with five runs last night.

Now, two very good starting pitchers will be clashing on the mound, and it wouldn’t be surprising if both of them get it going here.

Woodruff has the ability to strike out 10 batters whenever he touches the rubber, and Smith has to like his matchup against a Brewers team that hasn’t been very productive against left-handed pitchers on the year.

PREDICTION: Under 7.5 (-104)

Brewers vs Diamondbacks betting card

  • Diamondbacks ML (+172)
  • Under 7.5 (-104)

Picks made on 6/23/2021 at 1:54 a.m. ET

MLB parlays

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