After a slow start to the series, Vladimir Guerrero Jr. has caught fire and played an instrumental role in helping Toronto climb out of an early 2-0 hole.
My Blue Jays vs. Mariners predictions see Guerrero Jr. building on his success and continuing to be a run scoring machine in Game 5. Let’s break down my October 17 MLB picks.
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Blue Jays vs Mariners Game 5 predictions
Who will win Blue Jays vs Mariners Game 5
Kevin Gausman has allowed two runs or fewer in six of his last eight starts, including both postseason appearances.
The Toronto Blue Jays scored 21 runs over the past two blowout victories and should be able to muster up a better offensive showing against Bryce Miller, who posted a 5.53 ERA in the regular season, this time around.
Blue Jays vs Mariners best bet
Vladimir Guerrero Jr. Over 0.5 runs (+120)
Vladimir Guerrero Jr. did not finish the regular season on a strong note, but you wouldn’t know it based on his playoff performance.
He has piled up the hits and the runs have followed, scoring nine times through eight games against the Yankees and Mariners.
Guerrero Jr. did not produce over the first two games against Seattle but has found his footing on the road. He’s picked up six hits, and four runs, since the series shifted to T-Mobile Park.
He is red-hot and should be able to keep it going against Bryce Miller. Vladdy hit .282 vs. righties in the regular season, while Miller conceded a .274 average to right-handed batters.
After seeing Miller earlier in this series, Guerrero Jr. should have a good idea of how Miller’s pitches move and what kind of adjustments need to be made.
He is a hit machine and also draws plenty of walks (be it earned or intentional), which could lead to multiple run-scoring opportunities.
Blue Jays vs Mariners Game 5 same-game parlay (SGP)
The Blue Jays lead the series 25-19 in aggregate. Their offense is suddenly red-hot, and they have the pitching advantage with veteran Kevin Gausman on the mound.
Josh Naylor recorded a hit in 74% of his regular season games, is coming off a three-hit performance, and owns a .308 average against Gausman in his career. He’s perhaps the most likely Seattle Mariners batter to pick up a hit.
Blue Jays vs Mariners SGP
- Vladimir Guerrero Jr. Over 0.5 runs
- Blue Jays moneyline
- Josh Naylor Over 0.5 hits
Blue Jays vs Mariners home run pick for Game 5
Daulton Varsho (+425)
Daulton Varsho hasn’t homered in six straight games, but he’s knocking on the door. He has already hit three balls 350+ feet in this series — including a 362-footer against Miller — and hammered one off the wall in Game 3.
Blue Jays vs Mariners Game 5 odds
- Moneyline: Toronto -110 | Seattle -110
- Run line: Toronto -1.5 (+165) | Seattle +1.5 (-200)
- Over/Under: Over 7.5 (-110) | Under 7.5 (-110)
Blue Jays vs Mariners trend
Vladimir Guerrero Jr. has scored a run in six of eight playoff games. Find more MLB betting trends for Blue Jays vs. Mariners.
How to watch Blue Jays vs Mariners and Game 5 info
| Location | T-Mobile Park, Seattle, WA |
| Date | Friday, October 17, 2025 |
| First pitch | 6:08 p.m. ET |
| TV | FS1 |
| Blue Jays starting pitcher | Kevin Gausman (1-1, 2.38 ERA) |
| Mariners starting pitcher | Bryce Miller (1-0, 2.61 ERA) |
Blue Jays vs Mariners latest injuries
Blue Jays vs Mariners weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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