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Best NFL Picks Today

Find the best NFL bets today - Sept. 23, 2026. Free expert and computer picks for every NFL game.

New Computer Picks powered by Odds Shark

Predicted Score

ATL logo
ATL
ATL

21.81 @ 25.59

GB
GB logo
GB

Falcons vs Packers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

ATL logo
ATL
ATL

21.81

+5.5 -114

o42.5 -118

+215

GB logo
GB
GB

25.59

-5.5 -105

u43.5 -112

-235

Kansas City @ Miami
Matchup Stats

Predicted Score

KC logo
KC
KC

25.87 @ 16.85

MIA
MIA logo
MIA

Chiefs vs Dolphins · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

KC logo
KC
KC

25.87

-11.5 -108

o45.5 -115

-676

MIA logo
MIA
MIA

16.85

+11.5 -109

u47.5 -150

+550

Top Projection De'Von Achane o60.5 Rushing Yards (-120)
o59.5-114
Carolina @ Cleveland
Matchup Stats

Predicted Score

CAR logo
CAR
CAR

20.55 @ 18.95

CLE
CLE logo
CLE

Panthers vs Browns · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

CAR logo
CAR
CAR

20.55

-2.5 -115

o41.5 -108

-143

CLE logo
CLE
CLE

18.95

+0.0 +117

u42.5 -110

+130

Top Projection Quinshon Judkins o46.5 Rushing Yards (-115)
o46.5-115
Tennessee @ N.Y. Giants
Matchup Stats

Predicted Score

TEN logo
TEN
TEN

17.16 @ 20.51

NYG
NYG logo
NYG

Titans vs Giants · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

TEN logo
TEN
TEN

17.16

+3.5 -133

o39.5 -105

+130

NYG logo
NYG
NYG

20.51

-3.5 -114

u40.0 -108

-142

Top Projection Jameis Winston o6.5 Rushing Yards (-115)
o6.5-115
New England @ Jacksonville
Matchup Stats

Predicted Score

NE logo
NE
NE

21.93 @ 23.51

JAC
JAC logo
JAC

Patriots vs Jaguars · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

NE logo
NE
NE

21.93

+3.0 -115

o44.5 -115

+135

JAC logo
JAC
JAC

23.51

-3.0 -105

u45.5 -110

-148

Top Projection TreVeyon Henderson o38.5 Rushing Yards (-115)
o38.5-115
L.A. Chargers @ Buffalo
Matchup Stats

Predicted Score

LAC logo
LAC
LAC

20.83 @ 26.42

BUF
BUF logo
BUF

Chargers vs Bills · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LAC logo
LAC
LAC

20.83

+7.5 -115

o49.5 -120

+300

BUF logo
BUF
BUF

26.42

-7.5 +100

u50.5 -115

-334

N.Y. Jets @ Detroit
Matchup Stats

Predicted Score

NYJ logo
NYJ
NYJ

19.30 @ 29.18

DET
DET logo
DET

Jets vs Lions · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

NYJ logo
NYJ
NYJ

19.30

+7.5 -135

o47.5 -108

+265

DET logo
DET
DET

29.18

-7.5 +110

u49.5 -140

-300

Top Projection Jared Goff o0.5 Rushing Yards (+140)
o0.5+140
Houston @ Indianapolis
Matchup Stats

Predicted Score

HOU logo
HOU
HOU

22.17 @ 22.50

IND
IND logo
IND

Texans vs Colts · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

HOU logo
HOU
HOU

22.17

-1.5 -135

o41.5 -132

-142

IND logo
IND
IND

22.50

+1.5 +105

u43.0 -110

+130

Top Projection David Montgomery o9.5 Receiving Yards (-115)
o9.5-115
Seattle @ Washington
Matchup Stats

Predicted Score

SEA logo
SEA
SEA

21.07 @ 16.77

WAS
WAS logo
WAS

Seahawks vs Commanders · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

SEA logo
SEA
SEA

21.07

-6.5 -124

o40.0 -110

-310

WAS logo
WAS
WAS

16.77

+6.5 +102

u40.5 -110

+280

Top Projection Stefon Diggs o35.5 Receiving Yards (-115)
o35.5-115
Cincinnati @ Pittsburgh
Matchup Stats

Predicted Score

CIN logo
CIN
CIN

25.13 @ 21.30

PIT
PIT logo
PIT

Bengals vs Steelers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

CIN logo
CIN
CIN

25.13

-3.5 -108

o42.5 -110

-185

PIT logo
PIT
PIT

21.30

+3.5 -105

u42.5 +100

+165

Top Projection Joe Burrow o254.5 Passing Yards (-115)
o249.5-115
Arizona @ San Francisco
Matchup Stats

Predicted Score

ARI logo
ARI
ARI

20.47 @ 26.76

SF
SF logo
SF

Cardinals vs 49ers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

ARI logo
ARI
ARI

20.47

+8.5 -105

o47.5 -110

+370

SF logo
SF
SF

26.76

-8.5 -108

u50.0 -145

-400

Top Projection Jacoby Brissett o7.5 Rushing Yards (-110)
o7.5-110
Minnesota @ Tampa Bay
Matchup Stats

Predicted Score

MIN logo
MIN
MIN

20.23 @ 21.04

TB
TB logo
TB

Vikings vs Buccaneers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

MIN logo
MIN
MIN

20.23

-1.5 -105

o41.5 -130

-120

TB logo
TB
TB

21.04

+1.5 -109

u43.0 -115

+106

Top Projection Kyler Murray o20.5 Rushing Yards (-118)
o20.5-111
Baltimore @ Dallas
Matchup Stats

Predicted Score

BAL logo
BAL
BAL

26.42 @ 26.81

DAL
DAL logo
DAL

Ravens vs Cowboys · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

BAL logo
BAL
BAL

26.42

-3.5 -102

o52.5 -106

-175

DAL logo
DAL
DAL

26.81

+3.5 -110

u53.0 -113

+155

Top Projection Dak Prescott o264.5 Passing Yards (-115)
o260.5-115
Las Vegas @ New Orleans
Matchup Stats

Predicted Score

LV logo
LV
LV

20.84 @ 25.74

NO
NO logo
NO

Raiders vs Saints · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LV logo
LV
LV

20.84

+5.5 -159

o43.5 -110

+160

NO logo
NO
NO

25.74

-5.5 +130

u44.0 -115

-168

Top Projection Michael Mayer Score a Touchdown (Yes: +325)
+475
L.A. Rams @ Denver
Matchup Stats

Predicted Score

LA logo
LA
LA

23.99 @ 22.87

DEN
DEN logo
DEN

Rams vs Broncos · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LA logo
LA
LA

23.99

-2.5 -110

o44.5 -120

-140

DEN logo
DEN
DEN

22.87

+2.5 -105

u45.5 -110

+121

Top Projection Bo Nix o210.5 Passing Yards (-120)
o210.5-120
Philadelphia @ Chicago
Matchup Stats

Predicted Score

PHI logo
PHI
PHI

22.27 @ 18.66

CHI
CHI logo
CHI

Eagles vs Bears · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

PHI logo
PHI
PHI

22.27

-4.5 -107

o41.0 -110

-220

CHI logo
CHI
CHI

18.66

+4.5 -105

u41.5 -112

+200

Top Projection Colston Loveland o25.5 Receiving Yards (-115)
o25.5-115
Atlanta Falcons image thumbnail ATL @ Green Bay Packers image thumbnail GB Thu, Sep 24 • 8:15 PM ET
Anytime Touchdown
Tucker Kraft logo Tucker Kraft Score a Touchdown (Yes: +218)
Best Odds
Pick made: an hour ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

The Falcons just watched Carolina tight end Darren Waller score two touchdowns in their Week 2 belly flop and face another TE with a nose for the end zone in Green Bay. Tucker Kraft scored six TDs in eight games before getting injured for the remainder of the season in 2025. In fact, Kraft struck for 13 touchdowns in his last 26 games going back to 2024. He’s yet to be targeted inside the red zone in 2026 but with the receiving corps missing bodies and Christian Watson playing through pain, Kraft could find himself running more routes (13th among all TE in routes run). Touchdown probabilities have Kraft’s chances at reeling in his first TD of the season between 30% and 41%. 

Anytime Touchdown
Tucker Kraft logo Tucker Kraft Score a Touchdown (Yes: +198)
Best Odds
Pick made: 3 hours ago
Joe Osborne logo
Joe Osborne
Senior Betting Analyst

Atlanta has already allowed three TDs to tight ends, giving Tucker Kraft a favorable matchup Thursday. He’s one of the few dependable playmakers in a depleted Packers offense, with Jayden Reed’s injury making him even more important to Jordan Love. Kraft scored six touchdowns in eight games last season, and Green Bay has every reason to feature him near the goal line.

View 20 Picks
Kansas City Chiefs image thumbnail KC @ Miami Dolphins image thumbnail MIA Sun, Sep 27 • 1:00 PM ET
Anytime Touchdown
Xavier Worthy logo Xavier Worthy Score a Touchdown (Yes: +181)
Best Odds
Pick made: 2 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

I got this at 2.8x with a fair price of 2.55x. It's the No. 2 TD on the Covers Anytime Value Index, and with Patrick Mahomes looking more pass than handoff in Week 2, this passing game could have a big three quarters of football against the Dolphins. Miami has a bottom-six defense in both EPA/play and success rate, but its dropback success rate and EPA/play rank as the second-worst unit in football. The Chiefs can do whatever they want on Sunday and put up 35+ points. Xavier Worthy has twice as many RZ targets through two games as Rashee Rice and is priced better. He also played more snaps and ran more routes than Rice in Week 2 and leads the team in target share at 20%. It's Worthy over Rice for me in Week 3.

Spread
Kansas City Chiefs image thumbnail KC -11.5 (-108)
Best Odds
Pick made: 6 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

This is undoubtedly one of my best bets for Week 3. We're seeing the biggest spread on the slate, and for good reason; the Fins enter this game with the largest point differential in the AFC (-36) and the fourth-worst red-zone defense in football. Expect Patrick Mahomes and Co. to play with their food and dominate.

View 12 Picks
Carolina Panthers image thumbnail CAR @ Cleveland Browns image thumbnail CLE Sun, Sep 27 • 1:00 PM ET
Anytime Touchdown
Denzel Boston logo Denzel Boston Score a Touchdown (Yes: +310)
Best Odds
Pick made: 4 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

I really wanted Quinshon Judkins at 2.25x against the Panthers, who are getting gashed on the ground. However, getting Denzel Boston at this price after two weeks of cashing still feels long, with a fair price around 3.2x. Judkins has not found any room to run through two games, but Boston already has a 21% target share and a whopping 52% of the air-yard share. The only wide receivers with a bigger AYS are Jaxon Smith-Njigba, Justin Jefferson, and Chris Olave — some big hitters. Boston can run the deep route for a score like he did in Week 1 or catch and run for yards like last week. He's beaten the Jaguars and Bucs. Surely, he can beat the Panthers, who gave up 59 points in Week 1 before having to play the worst QB tandem in the history of the sport in Week 2.

Rushing Yards
Quinshon Judkins logo Quinshon Judkins o43.5 Rushing Yards (-115)
Best Odds
Pick made: yesterday
Neil Parker logo
Neil Parker
Betting Analyst

This Judkins Over is in play to 46.5 because Carolina has allowed the highest yards per carry (6.31) to opposing running backs while ranking 29th in run defense DVOA through two weeks. The Cleveland rusher also cleared this total in nine of 14 games last season, and he has handled 75% of running back carries with a 66% snap share to start 2026. Judkins’ go-to role positions him to scamper well Over this number in the soft Week 3 matchup.

View 14 Picks
Tennessee Titans image thumbnail TEN @ New York Giants image thumbnail NYG Sun, Sep 27 • 1:00 PM ET
Anytime Touchdown
Elic Ayomanor logo Elic Ayomanor Score a Touchdown (Yes: +850)
Best Odds
Pick made: 2 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

Elic Ayomanor might be WR2 facing a Giants defense that is on a short week and dealing with cluster injuries at corner. Davante Adams did whatever he wanted on MNF because of the lack of NFL talent at corner. Ayomanor should not be longer than 5.5x. He's playing better than Calvin Ridley and is getting targeted on 20% of his routes while sitting second on the team in air-yard share at 30%. He also has all of the WR red-zone targets at three through two games, with a TD. It's a longer shot here, but certainly +EV. The only thing knocking it is a bad pass offense, but the Eagles and Jets are a lot different than the Giants, who have allowed a red-zone touchdown on all six of their opponents' trips inside the 20.

Spread
New York Giants image thumbnail NYG -5.5 (-115)
Best Odds
Pick made: 2 days ago
Neil Parker logo
Neil Parker
Betting Analyst

Grabbing this -5.5 line before Monday Night Football because I’m expecting the Giants to hang with the Los Angeles Rams in Week 2, and New York will be an even larger home favorite over Tennessee by Sunday afternoon. The Titans were only on offense for 23:35 against the Philadelphia Eagles on Sunday, and QB Cam Ward has thrown for just 6.2 yards per attempt through two weeks. Tennessee also hits the highway for the first time in 2026, and the new-look G-Men put on an offensive clinic in their season opener at MetLife Stadium. 

View 10 Picks
New England Patriots image thumbnail NE @ Jacksonville Jaguars image thumbnail JAC Sun, Sep 27 • 1:00 PM ET
Total
New England Patriots image thumbnail Jacksonville Jaguars image thumbnail u45.5 (-115)
Best Odds
Pick made: an hour ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

Two of the top scoring defenses in the NFL up against two passing attacks that have left a lot to be desired over two weeks just screams like an Under to me. Points will be tough to come by here; the Pats have yet to give up a red-zone touchdown, while the Jags are allowing a score at just a 28% clip inside the 20. I'm riding this play as one of my best bets of the day.

Spread
Jacksonville Jaguars image thumbnail JAC -2.5 (-123)
Best Odds
Pick made: 4 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

My belief in the Pats' offense is next to zero. Drake Maye starting the season with 1 touchdown against four picks furthers the narrative that he was a schedule merchant last year. New England's passing offense is among the worst in football through two weeks, averaging just 179 yards in the air per game. I'm expecting this Jags defense to eat them alive in a low-scoring battle at home.

View 13 Picks
Los Angeles Chargers image thumbnail LAC @ Buffalo Bills image thumbnail BUF Sun, Sep 27 • 1:00 PM ET
Total
Los Angeles Chargers image thumbnail Buffalo Bills image thumbnail o50.5 (-105)
Best Odds
Pick made: 4 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

The Bills are 2-0 to the Over this year due to their potent offense. However, their defense is my primary selling point here. Buffalo has been involved in two shootouts this season, a 36-31 win in Week 1 against Houston and a 41-31 victory against the Lions in Week 2 - coughing 368 yards per game as a result. I'm expecting the Chargers to finally put together a game under Mike McDaniel here, with a total that should be closer to 55.5. Punts will be few and far between on Sunday.

Anytime Touchdown
Oronde Gadsden logo Oronde Gadsden Score a Touchdown (Yes: +310)
Best Odds
Pick made: 4 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

With both David Njoku and Charlie Kolar out long-term, Oronde Gadsden is set to pick up some snaps and is coming off a TD in Week 2 that paid 5.75x last week. The price move is still within the buy range, as I have a fair price for a possible No. 2 pass-catcher in this offense as a hefty dog closer to 3x, compared to the 4.1x price tag early in the week. Ladd McConkey is playing through his rib injury, and the rest of the pass-catchers in this offense are invisible. The unit as a whole has been bad. However, there will be plenty of passing opportunities for this Los Angeles offense, as its defense is one of the worst in football, while the Bills' defense has still allowed 62 points in two games.

View 13 Picks
New York Jets image thumbnail NYJ @ Detroit Lions image thumbnail DET Sun, Sep 27 • 1:00 PM ET
Anytime Touchdown
Garrett Wilson logo Garrett Wilson Score a Touchdown (Yes: +170)
Best Odds
Pick made: 3 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

There are a lot of Jets angles I want here. The Lions have been awful at defending the TE position early in the season, as even the Saints had TDs from Juwan Johnson and Noah Fant in Week 1. The problem is that the Jets have a four-TE rotation, with Kenyon Sadiq at 5.1x being a possibility, but I'm looking elsewhere. Adonai Mitchell (4.1x) had 12 targets last week and leads the Jets in target and air-yard share, but I don't want to get cute when Garrett Wilson is 2.5x or better. It's an indoor game with a high total, and Wilson also ranks high on the Covers Anytime TD Value Index. The Jets could put up points against this toothless defense, and a move from 2.8x last week to 2.7x this week isn't enough for the setting and matchup.

Total
New York Jets image thumbnail Detroit Lions image thumbnail u48.5 (-120)
Best Odds
Pick made: yesterday
Ed Scimia logo
Ed Scimia
Betting Analyst

The New York Jets have allowed just 4.0 yards per play, third-best in the NFL, and rank sixth in EPA per defensive play for the season. And while the Detroit Lions have given up an embarrassing 457.5 yards per game on defense, Geno Smith and the New York offense haven't shown any signs that they can even approach that kind of number. I'm backing the Under at totals as low as 47.5 points.

View 13 Picks
Houston Texans image thumbnail HOU @ Indianapolis Colts image thumbnail IND Sun, Sep 27 • 1:00 PM ET
Anytime Touchdown
David Montgomery logo David Montgomery Score a Touchdown (Yes: -115)
Best Odds
Pick made: 2 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

Your TD card can't be littered with long shots, and getting a clear-cut No. 1 running back with the short-yardage role against the worst points-per-game defense at 1.87x is still a great deal. This should come with a fair price of 1.69x, or 59% vs. 53%. Every position has been padding stats against the Colts this year, and running backs are no exception. Only two other teams are giving up more fantasy points to opposing running backs than the Colts, who gave up 41 points last week and got run over by Kenneth Walker, who likely should have had a TD count. In Week 2, they allowed 5.2 yards per rush, and in Week 1, that number was 5.5. It's another indoor game, and David Montgomery should look more like his Week 1 self than his Week 2 output, when he had two TDs on 20 carries.

Total
Houston Texans image thumbnail Indianapolis Colts image thumbnail o43.5 (-116)
Best Odds
Pick made: 2 days ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

We have two teams that have hit the Over in three of four games this year, leading me to believe that this number is far too low. The Colts' defense is simply the worst in football so far, giving up a total of eight touchdowns through two weeks. Most of these are due to a struggling red-zone unit, which is coughing up a score 67% of the time. So what's been working for Indy? Undeniably, its offense, which is scoring at an 84% clip once they get inside the 20. While yes, the Colts are going up against one of the better defensive units in football, Houston has still allowed over 350 yards of total offense in the early parts of 2026. What does this all add up to? An Over. Play this up to 55%.

View 13 Picks
Seattle Seahawks image thumbnail SEA @ Washington Commanders image thumbnail WAS Sun, Sep 27 • 1:00 PM ET
Passing Yards
Marcus Mariota logo
Marcus Mariota o175.5 Passing Yards (-115)
Projection 187.92 (Over)
Best Odds
Pick made: 3 minutes ago
EV Model Rating
Star rating: 4 out of 5
The Commanders will be rolling with backup QB Marcus Mariota in this game, which generally means fewer pass attempts and more rush attempts.. The Commanders are a 6.5-point underdog in this week's game, likely creating a passing game script.. The Seahawks defense has been a glaring pass funnel since the start of last season, tempting opposing quarterbacks to attempt the 4th-most passes in the league (35.7 per game) since the start of last season.
Rushing Yards
Marcus Mariota logo
Marcus Mariota o20.5 Rushing Yards (-115)
Projection 24.91 (Over)
Best Odds
Pick made: 3 minutes ago
EV Model Rating
Star rating: 4 out of 5
Our trusted projections expect the Commanders to be the 8th-most run-oriented team among all teams this week with a 45.4% run rate, based on their underlying traits and matchup dynamics.. The projections expect Marcus Mariota to earn 5.2 carries in this contest, on balance: the 9th-most among all quarterbacks.. The predictive model expects Marcus Mariota to be a more important option in his team's run game in this contest (19.6% projected Carry Share) than he has been since the start of last season (13.8% in games he has played).. The Seattle defensive tackles rank as the 8th-worst group of DTs in football since the start of last season with their run defense.
View 4 Picks
Cincinnati Bengals image thumbnail CIN @ Pittsburgh Steelers image thumbnail PIT Sun, Sep 27 • 1:00 PM ET
Moneyline
Cincinnati Bengals image thumbnail CIN (-174)
Best Odds
Pick made: 2 days ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Pittsburgh takes a series step up in competition and this is no longer the Steelers we could count on under Mike Tomlin. Aaron Rodgers is done and Cincinnati is looking like the best two-way team in the NFL, after handling Houston on the road in Week 3. The Bengals have collected eight sacks in the first two games and I wouldn’t be surprised if Rodgers doesn’t make it through Week 3, given the pounding he took in New England.  Oh, and Joe Burrow is absolutely firing on all cylinders. He’s surgical versus zone coverage and will slice up Patrick Graham’s passive playcalling. I'm taking Cincy ML before this price ticks up to two bucks or higher.

Passing Yards
Aaron Rodgers logo
Aaron Rodgers o220.5 Passing Yards (-114)
Projection 251.76 (Over)
Best Odds
Pick made: 19 minutes ago
EV Model Rating
Star rating: 5 out of 5
The Steelers are a 3.5-point underdog in this game, which points towards a passing game script.. The model projects the Steelers as the 3rd-most pass-heavy offense among all teams this week with a 65.5% pass rate, based on their underlying propensities and matchup dynamics.. Accounting for the game dynamics and the underlying approaches of each team, this game is projected by the predictive model to see 129.2 offensive plays called: the 5th-most among all games this week.. In this week's game, Aaron Rodgers is predicted by our trusted projection set to wind up with the 3rd-most pass attempts among all QBs with 39.1. . Since the start of last season, the deficient Cincinnati Bengals defense has conceded a staggering 247.0 adjusted yards per game through the air to opposing offenses: the 3rd-most in the league.
View 11 Picks
Arizona Cardinals image thumbnail ARI @ San Francisco 49ers image thumbnail SF Sun, Sep 27 • 4:05 PM ET
Receiving Yards
Michael Wilson logo
Michael Wilson o44.5 Receiving Yards (-115)
Projection 51.92 (Over)
Best Odds
Pick made: a minute ago
EV Model Rating
Star rating: 5 out of 5
An extreme passing game script is suggested by the Cardinals being an enormous -8.5-point underdog in this week's game.. The model projects the Arizona Cardinals as the 4th-most pass-focused team on the slate this week with a 63.2% pass rate, given their underlying propensities and matchup dynamics.. The Cardinals have run the 7th-most plays in the NFL since the start of last season, totaling a monstrous 59.2 plays per game.. Michael Wilson has run a route on 85.8% of his team's dropbacks since the start of last season, ranking him in the 83rd percentile among wideouts.. Since the start of last season, the feeble San Francisco 49ers defense has been gouged for the 7th-most yards-after-the-catch in the NFL to opposing wideouts: a monstrous 0.52 YAC.
Rushing Yards
Jacoby Brissett logo
Jacoby Brissett o7.5 Rushing Yards (-110)
Projection 15.78 (Over)
Best Odds
Pick made: 7 minutes ago
EV Model Rating
Star rating: 5 out of 5
The Cardinals have run the 7th-most plays in the NFL since the start of last season, totaling a monstrous 59.2 plays per game.. The Arizona Cardinals have played in the 3rd-most "low wind" (4-mph or less) games in football since the start of last season, which ought to mean reduced pass volume, higher running volume, and reduced offense efficiency when facing windier conditions in this game.
View 10 Picks
Minnesota Vikings image thumbnail MIN @ Tampa Bay Buccaneers image thumbnail TB Sun, Sep 27 • 4:05 PM ET
Spread
Tampa Bay Buccaneers image thumbnail TB +1.5 (-106)
Best Odds
Pick made: 7 hours ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Defensive masterminds Todd Bowles and Brian Flores send extra pass rushers more than most, which has me measuring just how the respective QBs will handle the heat. Baker Mayfield has been solid versus the blitz during this time in Tampa, with an uncanny ability to sneak away from pressure and either make a play with his legs or squeeze in a release pass. Kyler Murray is expected to be under center after having his Vikings debut cut short due to a concussion in Week 1. Murray hasn’t been great against blitzes during this career and had only 11 full-speed snaps (five dropbacks) in Kevin O’Connell’s offense before getting hurt. We’re getting Tampa Bay at a discount. It was originally a 1.5-point home favorite on the look-ahead market and sat at that same spread before the results of Week 2.

Total
Minnesota Vikings image thumbnail Tampa Bay Buccaneers image thumbnail u42.5 (-108)
Best Odds
Pick made: 2 days ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

We're seeing two mediocre offenses against two top-10 defenses in Week 3. The Vikings have had to play mistake-free football on both sides of the ball - their defense has allowed an average of just 12.5 points per game as a result. It's also one of the best red-zone defenses this year, allowing a touchdown on just 12% of trips inside the 20. With positive regression looming for the Bucs' defense against Murray and Co. I'm projecting this total to close closer to 40.5.

View 13 Picks
Baltimore Ravens image thumbnail BAL @ Dallas Cowboys image thumbnail DAL Sun, Sep 27 • 4:25 PM ET
Anytime Touchdown
Mark Andrews logo Mark Andrews Score a Touchdown (Yes: +146)
Best Odds
Pick made: 2 hours ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

The Ravens’ receiving corps is banged up with injuries to Zay Flowers and Ja'Kobi Lane, upping TE Mark Andrews spot in the pass-catching pecking order. The veteran tight end is heavily involved, playing in more than 70% of snaps and running the 12th most routes among all TEs. He’s reeled in 10 of 13 targets for just under 100 yards in two games. Andrews has been targeted only once inside the red zone yet faces a Dallas defense not only having issues with the run but also rival tight ends. The Cowboys have allowed 11 receptions to the position, two of which were for touchdowns. Touchdown probabilities park Andrews chances at finding the end zone between 30% and 56%, with most models around 40%. 

Rushing Yards
Lamar Jackson logo Lamar Jackson o35.5 Rushing Yards (-115)
Best Odds
Pick made: 3 hours ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

A dual-threat QB like Lamar Jackson can roll through that Dallas defense like a carnival float. The Cowboys can’t contain fleet-footed quarterbacks, having allowed a league-high 126 rushing yards to the likes of Jaxson Dart and Jayden Daniels – the latter of which only played the first half (69 rushing yards). Jackson’s rushing efforts have been modest through two games, amassing 40 and 34 yards in the opening two games. However, he told reporters he’s still a big part of the running playbook heading into Week 3. Lamar’s forecasts differ, ranging from 31.5 to 51 rushing yards in Week 3. My number comes out to 44 rushing yards but leans to the higher ceiling given the matchup.

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Las Vegas Raiders image thumbnail LV @ New Orleans Saints image thumbnail NO Sun, Sep 27 • 4:25 PM ET
Spread
Las Vegas Raiders image thumbnail LV +3.5 (-120)
Best Odds
Pick made: 6 hours ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Vegas' new defensive coordinator Rob Leonard is creating tremendous pressure with his front four (No. 1 pressure rate despite blitzing on only 22% of snaps), collecting eight sacks and 10 QB hits. The Raiders now set their sights on second-year QB Tyler Shough. His PFF profile doesn’t paint a pretty picture under pressure. As a rookie, Shough was night and day when kept clean vs. under duress, rating 27th among qualifying QBs. The 2026 season produces a similar split, rating No. 5 when clean but 18th under pressure. It just so happens an already stressed New Orleans offensive line will be without starting LT Kelvin Banks for a while due to an ankle injury in Week 2. The Saints pass protection has already allowed eight sacks and ranks 28th in pass block win rate.

Anytime Touchdown
Tyler Shough logo
Tyler Shough Score a Touchdown (Yes: +270)
Projection 0.32 (Yes)
Best Odds
Pick made: an hour ago
EV Model Rating
Star rating: 4 out of 5
The model projects the Saints to be the 8th-most pass-heavy team on the slate this week with a 61.2% pass rate, based on their underlying play style and matchup dynamics.. Our trusted projections expect the New Orleans Saints to be the 6th-most pass-centric offense in the league near the end zone (context-neutralized) right now with a 61.4% red zone pass rate.. The projections expect this game to have the highest number of plays run among all games this week at 133.7 plays, based on the traits of each team and game dynamics.. The New Orleans Saints have called the 3rd-most plays in the league since the start of last season, totaling a staggering 60.4 plays per game.. The passing attacks of both teams (including both volume and efficiency) ought to benefit from the calm "weather" conditions (i.e. zero wind) inside this dome, while ground volume may suffer.
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Los Angeles Rams image thumbnail LA @ Denver Broncos image thumbnail DEN Sun, Sep 27 • 8:20 PM ET
Rushing Yards
Kyren Williams logo
Kyren Williams o51.5 Rushing Yards (-115)
Projection 54.42 (Over)
Best Odds
Pick made: 9 minutes ago
EV Model Rating
Star rating: 4 out of 5
The model projects this game to see the 4th-most plays run among all games this week at 129.8 plays, accounting for the play styles of each team and game dynamics.. The Rams have played in the 10th-most "low wind" (4-mph or less) games in the NFL since the start of last season, which ought to lead to lower pass volume, increased running volume, and reduced passing offense performance when facing windier conditions in this week's game.. Kyren Williams has grinded out 70.0 adjusted rushing yards per game since the start of last season, one of the largest marks in football when it comes to RBs (97th percentile).. With a fantastic record of 5.86 adjusted yards per carry (91st percentile), Kyren Williams ranks as one of the top RBs in football this year.. Kyren Williams comes in as one of the leading running backs in the NFL at generating extra rushing yardage, averaging an exceptional 3.35 yards-after-contact this year while grading out in the 80th percentile.
Receiving Yards
Evan Engram logo
Evan Engram o22.5 Receiving Yards (-115)
Projection 26.8 (Over)
Best Odds
Pick made: 21 minutes ago
EV Model Rating
Star rating: 4 out of 5
The projections expect the Denver Broncos to be the 4th-most pass-centric offense on the slate this week with a 62.2% pass rate, given their underlying traits and matchup dynamics.. Based on their underlying play style and game dynamics, the Broncos are expected by our trusted projection set to run 65.3 plays on offense in this contest: the 6th-most on the slate this week.. The Denver Broncos have called the 9th-most plays in the NFL since the start of last season, averaging a colossal 58.4 plays per game.. The Los Angeles Rams defense has been a glaring pass funnel since the start of last season, causing opposing quarterbacks to attempt the 6th-most passes in the league (34.2 per game) since the start of last season.. Evan Engram's receiving reliability have been refined this year, with his Adjusted Completion Rate increasing from 68.7% to 100.0%.
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Philadelphia Eagles image thumbnail PHI @ Chicago Bears image thumbnail CHI Mon, Sep 28 • 8:15 PM ET
Rushing Yards
D'Andre Swift logo
D'Andre Swift u70.5 Rushing Yards (-115)
Projection 62.44 (Under)
Best Odds
Pick made: 21 minutes ago
EV Model Rating
Star rating: 5 out of 5
The Chicago Bears may pass less in this week's game (and call more rushes) given that they be rolling out backup QB Case Keenum.. This week's spread indicates a throwing game script for the Bears, who are -4.5-point underdogs.. Since the start of last season, the poor Philadelphia Eagles run defense has been gouged for a monstrous 4.14 adjusted yards-per-carry (YPC) to the opposition's run game: the 24th-highest rate in football.. The Philadelphia Eagles defensive tackles rank as the 2nd-best group of DTs in football since the start of last season in regard to defending the run.
Receiving Yards
Colston Loveland logo
Colston Loveland o25.5 Receiving Yards (-115)
Projection 38.83 (Over)
Best Odds
Pick made: 23 minutes ago
EV Model Rating
Star rating: 5 out of 5
The Chicago Bears may pass less in this week's game (and call more rushes) given that they be rolling out backup QB Case Keenum.. This week's spread indicates a throwing game script for the Bears, who are -4.5-point underdogs.. Our trusted projections expect this game to see the 5th-highest number of plays run among all games this week at 128.9 plays, accounting for the approaches of each team and game dynamics.. The Chicago Bears have run the 2nd-most plays in football since the start of last season, totaling a colossal 61.1 plays per game.. The Chicago O-line ranks as the 6th-best in the league since the start of last season in protecting the passer, which has a positive influence on all passing game stats across the board.
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For every matchup in an NFL season, our NFL computer produces selections for a variety of different betting angles. Our computer picks are based on a proprietary algorithm that values each team in the current week to produce moneyline, spread, and point total selections.

The table above, below the game picks, tracks our NFL computer's results over the last 100 games, outlining the record and profit for selections, based on $100 unit size. We track the profit based on both opening and closing lines for every matchup.

How to Use NFL Computer Picks

The easiest way to utilize our computer picks is to simply follow our selections for every matchup, what you'd call ailing the computer." But there are other ways to utilize our NFL computer picks, as well.

You can use our NFL computer as a jumping-off point to do more research into specific lines, cross-referencing with expert picks, which can be found above the selections for some matchups, recent NFL betting trends, and more.

As well, you can gauge the confidence of the matchup. The larger the projected score, the more confident the computer is in a specific pick.

Or, if you want to implement a system, betting only on underdogs, for example, you can look for matchups in which our computer likes the underdog to inform which picks you're going to hone in on for a given week.

We have these computer picks for every sport you're looking to wager on, as well:

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Moneyline

NFL moneyline picks are the simplest way to get in on the NFL action. All you have to do is simply bet on which team you think will win the game.

For moneyline picks, the favorite is represented with a minus sign (-) in front of the odds, while the underdog has a plus (+). However, you don't get the same profit for picking an underdog compared to a favorite. If the favored team is -120, a $100 bet on them would pay out $80 in profit and $180 total, if they win the game. The underdog winning at +150 would pay out a $150 profit, $250 total.

We have a complete breakdown of how to read NFL moneyline odds for these NFL computer picks.

Spread

While moneyline picks are the simplest, picking NFL games against the spread is probably the most common wager for regular NFL bettors.

To bet an NFL spread, you wager on whether a team will win by a certain number of points or more or if they'll lose by fewer points than the spread. For example, if the spread is -6.5 for the New England Patriots, you would win the bet if they win the game by 7 points or more. Or if a team is +6.5, you're betting on if they'll win outright or lose by fewer than 6.5 points.

There is a correlation between moneyline odds and the spread, as books set these lines based on the same information.

You can read more about NFL spreads here.

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If you aren’t entirely sold on which NFL team will win or cover in an NFL game, you can still use our NFL computer picks to bet on the point total.

As opposed to taking a side, in total or Over/Under betting, you wager on whether both NFL teams will combine for a final score of more than (Over) or less than (Under) the total number of points set by oddsmakers.

The computer picks, and your handicapping of totals is more about how you think both teams will score points, not which team has the edge to win.

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