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Best NFL Picks Today

Find the best NFL bets today - Sept. 23, 2026. Free expert and computer picks for every NFL game.

New Computer Picks powered by Odds Shark

Predicted Score

ATL logo
ATL
ATL

21.81 @ 25.59

GB
GB logo
GB

Falcons vs Packers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

ATL logo
ATL
ATL

21.81

+5.5 -105

o42.5 -118

+220

GB logo
GB
GB

25.59

-5.5 -105

u43.5 -112

-250

Kansas City @ Miami
Matchup Stats

Predicted Score

KC logo
KC
KC

25.88 @ 16.86

MIA
MIA logo
MIA

Chiefs vs Dolphins · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

KC logo
KC
KC

25.88

-10.5 -110

o45.5 -115

-699

MIA logo
MIA
MIA

16.86

+10.5 -108

u46.5 -110

+600

Top Projection Patrick Mahomes o13.5 Rushing Yards (-115)
o13.5-115
Carolina @ Cleveland
Matchup Stats

Predicted Score

CAR logo
CAR
CAR

20.55 @ 18.96

CLE
CLE logo
CLE

Panthers vs Browns · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

CAR logo
CAR
CAR

20.55

+0.0 -155

o41.5 -112

-148

CLE logo
CLE
CLE

18.96

+2.5 +105

u42.5 -110

+130

Top Projection Quinshon Judkins o46.5 Rushing Yards (-115)
o46.5-115
Tennessee @ N.Y. Giants
Matchup Stats

Predicted Score

TEN logo
TEN
TEN

17.16 @ 20.51

NYG
NYG logo
NYG

Titans vs Giants · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

TEN logo
TEN
TEN

17.16

+3.5 -133

o39.5 -105

+130

NYG logo
NYG
NYG

20.51

-3.5 -114

u40.0 -108

-135

Top Projection Jameis Winston o6.5 Rushing Yards (-110)
o6.5-110
New England @ Jacksonville
Matchup Stats

Predicted Score

NE logo
NE
NE

21.93 @ 23.52

JAC
JAC logo
JAC

Patriots vs Jaguars · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

NE logo
NE
NE

21.93

+3.0 -115

o45.0 -110

+135

JAC logo
JAC
JAC

23.52

-3.0 -105

u45.5 -110

-148

Top Projection TreVeyon Henderson o41.5 Rushing Yards (-118)
o38.5-115
L.A. Chargers @ Buffalo
Matchup Stats

Predicted Score

LAC logo
LAC
LAC

20.83 @ 26.42

BUF
BUF logo
BUF

Chargers vs Bills · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LAC logo
LAC
LAC

20.83

+7.5 -115

o50.0 -110

+300

BUF logo
BUF
BUF

26.42

-7.5 +100

u50.5 -115

-334

Top Projection Omarion Hampton o60.5 Rushing Yards (-111)
o56.5-115
N.Y. Jets @ Detroit
Matchup Stats

Predicted Score

NYJ logo
NYJ
NYJ

19.31 @ 29.18

DET
DET logo
DET

Jets vs Lions · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

NYJ logo
NYJ
NYJ

19.31

+6.5 -102

o47.5 -105

+260

DET logo
DET
DET

29.18

-6.5 -110

u48.0 -115

-290

Top Projection Jared Goff o0.5 Rushing Yards (+125)
o0.5+125
Houston @ Indianapolis
Matchup Stats

Predicted Score

HOU logo
HOU
HOU

22.18 @ 22.50

IND
IND logo
IND

Texans vs Colts · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

HOU logo
HOU
HOU

22.18

-2.5 -115

o42.5 -110

-145

IND logo
IND
IND

22.50

+2.5 +100

u43.0 -110

+130

Top Projection David Montgomery o9.5 Receiving Yards (-115)
o9.5-115
Seattle @ Washington
Matchup Stats

Predicted Score

SEA logo
SEA
SEA

21.08 @ 16.77

WAS
WAS logo
WAS

Seahawks vs Commanders · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

SEA logo
SEA
SEA

21.08

-6.5 -120

o40.0 -110

-298

WAS logo
WAS
WAS

16.77

+6.5 +102

u40.5 -110

+270

Top Projection Marcus Mariota o175.5 Passing Yards (-115)
o175.5-115
Cincinnati @ Pittsburgh
Matchup Stats

Predicted Score

CIN logo
CIN
CIN

25.01 @ 21.32

PIT
PIT logo
PIT

Bengals vs Steelers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

CIN logo
CIN
CIN

25.01

+0.0 -195

o42.5 -110

-184

PIT logo
PIT
PIT

21.32

+3.5 -105

u43.5 -120

+160

Top Projection Joe Burrow o252.5 Passing Yards (-112)
o246.5-116
Arizona @ San Francisco
Matchup Stats

Predicted Score

ARI logo
ARI
ARI

20.47 @ 26.76

SF
SF logo
SF

Cardinals vs 49ers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

ARI logo
ARI
ARI

20.47

+8.5 -109

o47.5 -110

+370

SF logo
SF
SF

26.76

-8.5 -105

u48.5 -115

-410

Top Projection Jacoby Brissett o7.5 Rushing Yards (-110)
o7.5-110
Minnesota @ Tampa Bay
Matchup Stats

Predicted Score

MIN logo
MIN
MIN

20.23 @ 21.04

TB
TB logo
TB

Vikings vs Buccaneers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

MIN logo
MIN
MIN

20.23

-1.5 -105

o42.5 -109

-120

TB logo
TB
TB

21.04

+1.5 -106

u42.5 -105

+106

Top Projection Kyler Murray o19.5 Rushing Yards (-120)
o19.5-120
Baltimore @ Dallas
Matchup Stats

Predicted Score

BAL logo
BAL
BAL

26.43 @ 26.81

DAL
DAL logo
DAL

Ravens vs Cowboys · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

BAL logo
BAL
BAL

26.43

-3.5 -102

o52.5 -106

-172

DAL logo
DAL
DAL

26.81

+3.5 -112

u53.0 -112

+155

Top Projection Dak Prescott o266.5 Passing Yards (-111)
o260.5-115
Las Vegas @ New Orleans
Matchup Stats

Predicted Score

LV logo
LV
LV

20.85 @ 25.74

NO
NO logo
NO

Raiders vs Saints · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LV logo
LV
LV

20.85

+3.5 -120

o43.5 -110

+160

NO logo
NO
NO

25.74

-3.5 +102

u44.0 -111

-168

Top Projection Michael Mayer Score a Touchdown (Yes: +350)
+475
L.A. Rams @ Denver
Matchup Stats

Predicted Score

LA logo
LA
LA

24.00 @ 22.87

DEN
DEN logo
DEN

Rams vs Broncos · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LA logo
LA
LA

24.00

-2.5 -110

o45.0 -108

-135

DEN logo
DEN
DEN

22.87

+2.5 -105

u45.5 -110

+120

Top Projection Bo Nix o210.5 Passing Yards (-115)
o210.5-115
Philadelphia @ Chicago
Matchup Stats

Predicted Score

PHI logo
PHI
PHI

22.28 @ 18.66

CHI
CHI logo
CHI

Eagles vs Bears · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

PHI logo
PHI
PHI

22.28

-4.5 -107

o40.5 -120

-217

CHI logo
CHI
CHI

18.66

+4.5 -105

u41.5 -110

+200

Top Projection Colston Loveland o24.5 Receiving Yards (-115)
o24.5-115
Atlanta Falcons image thumbnail ATL @ Green Bay Packers image thumbnail GB Thu, Sep 24 • 8:15 PM ET
Anytime Touchdown
Tucker Kraft logo Tucker Kraft Score a Touchdown (Yes: +198)
Best Odds
Pick made: 24 minutes ago
Joe Osborne logo
Joe Osborne
Senior Betting Analyst

Atlanta has already allowed three TDs to tight ends, giving Tucker Kraft a favorable matchup Thursday. He’s one of the few dependable playmakers in a depleted Packers offense, with Jayden Reed’s injury making him even more important to Jordan Love. Kraft scored six touchdowns in eight games last season, and Green Bay has every reason to feature him near the goal line.

Spread
Green Bay Packers image thumbnail GB -5.5 (-105)
Best Odds
Pick made: 14 hours ago
Jon Metler logo
Jon Metler
Betting Analyst

Give me the Green Bay Packers on Thursday Night Football as a 5.5-point favorite, as I price them closer to a 6.5-point favorite in this matchup. Sure, Michael Penix Jr. is back, which means Falcons fans don't have to suffer through Cooper Rush anymore, but this is Penix's first game back in 10 months following major knee surgery, and he'll be facing a tough road environment. The market is moving toward the Falcons, as the Packers were initially 7-point favorites following their Week 2 overtime victory over the New York Jets. But with the line dropping to Packers -5.5, there's a buy opportunity here, as I make the Packers closer to -6.5 and believe the opening line was closer to the correct number.

View 19 Picks
Kansas City Chiefs image thumbnail KC @ Miami Dolphins image thumbnail MIA Sun, Sep 27 • 1:00 PM ET
Spread
Kansas City Chiefs image thumbnail KC -11.5 (-108)
Best Odds
Pick made: 2 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

This is undoubtedly one of my best bets for Week 3. We're seeing the biggest spread on the slate, and for good reason; the Fins enter this game with the largest point differential in the AFC (-36) and the fourth-worst red-zone defense in football. Expect Patrick Mahomes and Co. to play with their food and dominate.

Rushing Yards
Patrick Mahomes logo
Patrick Mahomes o14.5 Rushing Yards (-115)
Projection 20.37 (Over)
Best Odds
Pick made: 29 seconds ago
EV Model Rating
Star rating: 5 out of 5
An extreme rushing game script is implied by the Chiefs being a heavy 11.5-point favorite this week.. The model projects the Kansas City Chiefs to be the 9th-most run-focused offense on the slate this week with a 45.2% run rate, based on their underlying play style and matchup dynamics.. The 8th-highest number of plays in the league have been called by the Kansas City Chiefs since the start of last season (a massive 59.1 per game on average).. In logging a staggering 3.9 rush attempts per game since the start of last season, Patrick Mahomes slots in among the top QBs in the NFL (83rd percentile) as it relates to rushing usage.. The Miami Dolphins defense owns the 2nd-worst efficiency against opposing running games since the start of last season, surrendering 5.27 adjusted yards-per-carry.
View 8 Picks
Carolina Panthers image thumbnail CAR @ Cleveland Browns image thumbnail CLE Sun, Sep 27 • 1:00 PM ET
Anytime Touchdown
Denzel Boston logo Denzel Boston Score a Touchdown (Yes: +310)
Best Odds
Pick made: 28 minutes ago
Josh Inglis logo
Josh Inglis
Betting Analyst

I really wanted Quinshon Judkins at 2.25x against the Panthers, who are getting gashed on the ground. However, getting Denzel Boston at this price after two weeks of cashing still feels long, with a fair price around 3.2x. Judkins has not found any room to run through two games, but Boston already has a 21% target share and a whopping 52% of the air-yard share. The only wide receivers with a bigger AYS are Jaxon Smith-Njigba, Justin Jefferson, and Chris Olave — some big hitters. Boston can run the deep route for a score like he did in Week 1 or catch and run for yards like last week. He's beaten the Jaguars and Bucs. Surely, he can beat the Panthers, who gave up 59 points in Week 1 before having to play the worst QB tandem in the history of the sport in Week 2.

Rushing Yards
Quinshon Judkins logo Quinshon Judkins o43.5 Rushing Yards (-115)
Best Odds
Pick made: 23 hours ago
Neil Parker logo
Neil Parker
Betting Analyst

This Judkins Over is in play to 46.5 because Carolina has allowed the highest yards per carry (6.31) to opposing running backs while ranking 29th in run defense DVOA through two weeks. The Cleveland rusher also cleared this total in nine of 14 games last season, and he has handled 75% of running back carries with a 66% snap share to start 2026. Judkins’ go-to role positions him to scamper well Over this number in the soft Week 3 matchup.

View 14 Picks
Tennessee Titans image thumbnail TEN @ New York Giants image thumbnail NYG Sun, Sep 27 • 1:00 PM ET
Spread
New York Giants image thumbnail NYG -5.5 (-115)
Best Odds
Pick made: 2 days ago
Neil Parker logo
Neil Parker
Betting Analyst

Grabbing this -5.5 line before Monday Night Football because I’m expecting the Giants to hang with the Los Angeles Rams in Week 2, and New York will be an even larger home favorite over Tennessee by Sunday afternoon. The Titans were only on offense for 23:35 against the Philadelphia Eagles on Sunday, and QB Cam Ward has thrown for just 6.2 yards per attempt through two weeks. Tennessee also hits the highway for the first time in 2026, and the new-look G-Men put on an offensive clinic in their season opener at MetLife Stadium. 

Passing Yards
Jameis Winston logo
Jameis Winston o199.5 Passing Yards (-115)
Projection 208.28 (Over)
Best Odds
Pick made: 10 minutes ago
EV Model Rating
Star rating: 4 out of 5
The New York Giants may take to the air less in this contest (and hand the ball off more) as a result of being be forced to start backup quarterback Jameis Winston.. The 4th-most plays in football have been called by the New York Giants since the start of last season (a monstrous 59.4 per game on average).. Since the start of last season, the weak Tennessee Titans defense has allowed a staggering 74.9% Adjusted Completion Rate to opposing quarterbacks: the 3rd-worst rate in the NFL.
View 7 Picks
New England Patriots image thumbnail NE @ Jacksonville Jaguars image thumbnail JAC Sun, Sep 27 • 1:00 PM ET
Spread
Jacksonville Jaguars image thumbnail JAC -2.5 (-123)
Best Odds
Pick made: an hour ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

My belief in the Pats' offense is next to zero. Drake Maye starting the season with 1 touchdown against four picks furthers the narrative that he was a schedule merchant last year. New England's passing offense is among the worst in football through two weeks, averaging just 179 yards in the air per game. I'm expecting this Jags defense to eat them alive in a low-scoring battle at home.

Spread
Jacksonville Jaguars image thumbnail JAC -2.5 (-110)
Best Odds
Pick made: 2 days ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

I won’t discount the Jaguars too much for having a tough day in Denver. Jacksonville gets to come home for what will be its only outing in Duval County until Week 8. The Patriots looked much better than they were against the corpse of Aaron Rodgers in Week 2. New England managed just 20 points – seven coming from a defensive score – went 4-for-12 on third down and 0 for 1 in the red zone. This Jaguars defense still did a lot right against the Broncos, standing tall on third downs and inside the red zone. I’ll take the home side short of the key number of three.

View 12 Picks
Los Angeles Chargers image thumbnail LAC @ Buffalo Bills image thumbnail BUF Sun, Sep 27 • 1:00 PM ET
Total
Los Angeles Chargers image thumbnail Buffalo Bills image thumbnail o50.5 (-105)
Best Odds
Pick made: 43 minutes ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

The Bills are 2-0 to the Over this year due to their potent offense. However, their defense is my primary selling point here. Buffalo has been involved in two shootouts this season, a 36-31 win in Week 1 against Houston and a 41-31 victory against the Lions in Week 2 - coughing 368 yards per game as a result. I'm expecting the Chargers to finally put together a game under Mike McDaniel here, with a total that should be closer to 55.5. Punts will be few and far between on Sunday.

Anytime Touchdown
Oronde Gadsden logo Oronde Gadsden Score a Touchdown (Yes: +310)
Best Odds
Pick made: an hour ago
Josh Inglis logo
Josh Inglis
Betting Analyst

With both David Njoku and Charlie Kolar out long-term, Oronde Gadsden is set to pick up some snaps and is coming off a TD in Week 2 that paid 5.75x last week. The price move is still within the buy range, as I have a fair price for a possible No. 2 pass-catcher in this offense as a hefty dog closer to 3x, compared to the 4.1x price tag early in the week. Ladd McConkey is playing through his rib injury, and the rest of the pass-catchers in this offense are invisible. The unit as a whole has been bad. However, there will be plenty of passing opportunities for this Los Angeles offense, as its defense is one of the worst in football, while the Bills' defense has still allowed 62 points in two games.

View 13 Picks
New York Jets image thumbnail NYJ @ Detroit Lions image thumbnail DET Sun, Sep 27 • 1:00 PM ET
Total
New York Jets image thumbnail Detroit Lions image thumbnail u48.5 (-120)
Best Odds
Pick made: yesterday
Ed Scimia logo
Ed Scimia
Betting Analyst

The New York Jets have allowed just 4.0 yards per play, third-best in the NFL, and rank sixth in EPA per defensive play for the season. And while the Detroit Lions have given up an embarrassing 457.5 yards per game on defense, Geno Smith and the New York offense haven't shown any signs that they can even approach that kind of number. I'm backing the Under at totals as low as 47.5 points.

Spread
Detroit Lions image thumbnail DET -6.5 (-116)
Best Odds
Pick made: yesterday
Ed Scimia logo
Ed Scimia
Betting Analyst

The New York Jets defense still looks legit, but the offense sputtered against its first real taste of adversity, totaling just 285 yards against the Green Bay Packers. That won't be enough to deal with a Detroit Lions team that has averaged 362 yards and 31.0 ppg on offense this season. I'm backing the Lions to cover at -6.5 points.

View 12 Picks
Houston Texans image thumbnail HOU @ Indianapolis Colts image thumbnail IND Sun, Sep 27 • 1:00 PM ET
Total
Houston Texans image thumbnail Indianapolis Colts image thumbnail o43.5 (-116)
Best Odds
Pick made: 2 days ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

We have two teams that have hit the Over in three of four games this year, leading me to believe that this number is far too low. The Colts' defense is simply the worst in football so far, giving up a total of eight touchdowns through two weeks. Most of these are due to a struggling red-zone unit, which is coughing up a score 67% of the time. So what's been working for Indy? Undeniably, its offense, which is scoring at an 84% clip once they get inside the 20. While yes, the Colts are going up against one of the better defensive units in football, Houston has still allowed over 350 yards of total offense in the early parts of 2026. What does this all add up to? An Over. Play this up to 55%.

Spread
Houston Texans image thumbnail HOU -2.5 (-137)
Best Odds
Pick made: 2 days ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

The Houston Texans defense has faced two of the most potent offenses in football, the Buffalo Bills and Cincinnati Bengals, and still comes out on top in virtually every statistical category against the Indianapolis Colts. The Colts have a major issue, allowing 514 total yards per game - the most in the NFL by almost 60 yards. That coincides with allowing 37 points per game, also the worst mark in the league. They'll be going up against an offense that ranks in the top 10 in yards per game, which is good enough for me to get behind the Texans, even if Nico Collins misses another game. I'm expecting David Montgomery to run all over Indy, which is allowing 5.4 yards per carry through two weeks of the season. Comfortably fade the Colts and play this up to 60%.

View 12 Picks
Seattle Seahawks image thumbnail SEA @ Washington Commanders image thumbnail WAS Sun, Sep 27 • 1:00 PM ET
Passing Yards
Marcus Mariota logo
Marcus Mariota o175.5 Passing Yards (-115)
Projection 187.92 (Over)
Best Odds
Pick made: 2 hours ago
EV Model Rating
Star rating: 5 out of 5
The Commanders will be rolling with backup QB Marcus Mariota in this game, which generally means fewer pass attempts and more rush attempts.. The Commanders are a 6.5-point underdog in this week's game, likely creating a passing game script.. The Seahawks defense has been a glaring pass funnel since the start of last season, tempting opposing quarterbacks to attempt the 4th-most passes in the league (35.7 per game) since the start of last season.
Rushing Yards
Jacory Croskey-Merritt logo
Jacory Croskey-Merritt o36.5 Rushing Yards (-115)
Projection 57.06 (Over)
Best Odds
Pick made: 2 hours ago
EV Model Rating
Star rating: 5 out of 5
Our trusted projections expect the Commanders to be the 5th-most run-oriented team among all teams this week with a 48.7% run rate, based on their underlying traits and matchup dynamics.. The Seattle defensive tackles rank as the 8th-worst group of DTs in football since the start of last season with their run defense.
View 4 Picks
Cincinnati Bengals image thumbnail CIN @ Pittsburgh Steelers image thumbnail PIT Sun, Sep 27 • 1:00 PM ET
Moneyline
Cincinnati Bengals image thumbnail CIN (-174)
Best Odds
Pick made: 2 days ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Pittsburgh takes a series step up in competition and this is no longer the Steelers we could count on under Mike Tomlin. Aaron Rodgers is done and Cincinnati is looking like the best two-way team in the NFL, after handling Houston on the road in Week 3. The Bengals have collected eight sacks in the first two games and I wouldn’t be surprised if Rodgers doesn’t make it through Week 3, given the pounding he took in New England.  Oh, and Joe Burrow is absolutely firing on all cylinders. He’s surgical versus zone coverage and will slice up Patrick Graham’s passive playcalling. I'm taking Cincy ML before this price ticks up to two bucks or higher.

Passing Yards
Joe Burrow logo
Joe Burrow o252.5 Passing Yards (-112)
Projection 309.57 (Over)
Best Odds
Pick made: 29 seconds ago
EV Model Rating
Star rating: 5 out of 5
The predictive model expects the Cincinnati Bengals to be the most pass-focused offense on the slate this week with a 64.7% pass rate, given their underlying play style and matchup dynamics.. The model projects the Cincinnati Bengals to be the 8th-fastest paced defense in football (context-neutralized) at the moment, leading opposing offenses to average 28.13 seconds per snap.. In this game, Joe Burrow is forecasted by our trusted projection set to total the most pass attempts among all quarterbacks with 38.7. . The Steelers defense has been a glaring pass funnel since the start of last season, leading opposing quarterbacks to attempt the 5th-most passes in the NFL (34.3 per game) since the start of last season.. Joe Burrow grades out as one of the best quarterbacks in the league since the start of last season, averaging an exceptional 202.0 adjusted yards per game while ranking in the 75th percentile.
View 11 Picks
Arizona Cardinals image thumbnail ARI @ San Francisco 49ers image thumbnail SF Sun, Sep 27 • 4:05 PM ET
Rushing Yards
Jacoby Brissett logo
Jacoby Brissett o7.5 Rushing Yards (-110)
Projection 15.78 (Over)
Best Odds
Pick made: 8 minutes ago
EV Model Rating
Star rating: 5 out of 5
The Cardinals have run the 7th-most plays in the NFL since the start of last season, totaling a monstrous 59.2 plays per game.. The Arizona Cardinals have played in the 3rd-most "low wind" (4-mph or less) games in football since the start of last season, which ought to mean reduced pass volume, higher running volume, and reduced offense efficiency when facing windier conditions in this game.
Receiving Yards
George Kittle logo
George Kittle o42.5 Receiving Yards (-115)
Projection 52.19 (Over)
Best Odds
Pick made: 8 minutes ago
EV Model Rating
Star rating: 5 out of 5
The model projects George Kittle to notch 5.3 targets in this game, on average, ranking him in the 86th percentile among tight ends.. George Kittle has been a key part of his team's passing offense, garnering a Target Share of 21.7% since the start of last season, which places him in the 98th percentile when it comes to tight ends.. George Kittle has posted a massive 45.0 air yards per game since the start of last season: 96th percentile among tight ends.. George Kittle has been one of the leading pass-game TEs since the start of last season, averaging a remarkable 47.0 adjusted yards per game while ranking in the 93rd percentile.. Since the start of last season, the porous Cardinals defense has been gouged for a monstrous 62.0 adjusted receiving yards per game to opposing TEs: the 4th-most in the NFL.
View 10 Picks
Minnesota Vikings image thumbnail MIN @ Tampa Bay Buccaneers image thumbnail TB Sun, Sep 27 • 4:05 PM ET
Spread
Tampa Bay Buccaneers image thumbnail TB +1.5 (-106)
Best Odds
Pick made: 3 hours ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Defensive masterminds Todd Bowles and Brian Flores send extra pass rushers more than most, which has me measuring just how the respective QBs will handle the heat. Baker Mayfield has been solid versus the blitz during this time in Tampa, with an uncanny ability to sneak away from pressure and either make a play with his legs or squeeze in a release pass. Kyler Murray is expected to be under center after having his Vikings debut cut short due to a concussion in Week 1. Murray hasn’t been great against blitzes during this career and had only 11 full-speed snaps (five dropbacks) in Kevin O’Connell’s offense before getting hurt. We’re getting Tampa Bay at a discount. It was originally a 1.5-point home favorite on the look-ahead market and sat at that same spread before the results of Week 2.

Total
Minnesota Vikings image thumbnail Tampa Bay Buccaneers image thumbnail u42.5 (-108)
Best Odds
Pick made: yesterday
Dustin Saracini logo
Dustin Saracini
Senior Analyst

We're seeing two mediocre offenses against two top-10 defenses in Week 3. The Vikings have had to play mistake-free football on both sides of the ball - their defense has allowed an average of just 12.5 points per game as a result. It's also one of the best red-zone defenses this year, allowing a touchdown on just 12% of trips inside the 20. With positive regression looming for the Bucs' defense against Murray and Co. I'm projecting this total to close closer to 40.5.

View 13 Picks
Baltimore Ravens image thumbnail BAL @ Dallas Cowboys image thumbnail DAL Sun, Sep 27 • 4:25 PM ET
Total
Baltimore Ravens image thumbnail Dallas Cowboys image thumbnail o52.5 (-105)
Best Odds
Pick made: 2 days ago
Neil Parker logo
Neil Parker
Betting Analyst

Baltimore just allowed New Orleans Saints QB Tyler Shough to throw for 7.4 yards per attempt with a 79.4 completion percentage in Week 2, and now the Ravens go up against a Dallas offense that’s fourth in both EPA per play and offensive success rate ahead of Monday Night Football in Week 2. Of course, there’s no stop on defense for the Cowboys, and the Ravens respectively check in sixth and third in the two highlighted metrics. Finally, I anticipate the trip south to Maracana Stadium to also take its toll on the two defenses in Week 3.

Passing Completions
Dak Prescott logo
Dak Prescott o25.5 Passing Completions (-105)
Projection 28.21 (Over)
Best Odds
Pick made: 2 minutes ago
EV Model Rating
Star rating: 4 out of 5
This game's spread suggests a throwing game script for the Cowboys, who are -3-point underdogs.. Accounting for their underlying strategic approach and matchup dynamics, the predictive model expects the Cowboys to pass on 67.4% of their chances: the greatest clip on the slate this week.. This game will be played in a dome—meaning no wind, higher pass volume, higher touchdown potential, and increased passing effectiveness.. Opposing quarterbacks have averaged 36.3 pass attempts per game versus the Ravens defense since the start of last season: 3rd-most in the NFL.. Dak Prescott's passing accuracy has improved this season, with his Adjusted Completion% jumping from 66.8% to 73.0%.
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Las Vegas Raiders image thumbnail LV @ New Orleans Saints image thumbnail NO Sun, Sep 27 • 4:25 PM ET
Spread
Las Vegas Raiders image thumbnail LV +3.5 (-120)
Best Odds
Pick made: 2 hours ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Vegas' new defensive coordinator Rob Leonard is creating tremendous pressure with his front four (No. 1 pressure rate despite blitzing on only 22% of snaps), collecting eight sacks and 10 QB hits. The Raiders now set their sights on second-year QB Tyler Shough. His PFF profile doesn’t paint a pretty picture under pressure. As a rookie, Shough was night and day when kept clean vs. under duress, rating 27th among qualifying QBs. The 2026 season produces a similar split, rating No. 5 when clean but 18th under pressure. It just so happens an already stressed New Orleans offensive line will be without starting LT Kelvin Banks for a while due to an ankle injury in Week 2. The Saints pass protection has already allowed eight sacks and ranks 28th in pass block win rate.

Receiving Yards
Juwan Johnson logo
Juwan Johnson o34.5 Receiving Yards (-115)
Projection 45.04 (Over)
Best Odds
Pick made: 6 minutes ago
EV Model Rating
Star rating: 5 out of 5
The Saints rank as the 8th-most pass-heavy team in the league (context-neutralized) this year with a 60.8% pass rate.. The projections expect this game to have the highest number of plays run among all games this week at 132.6 plays, based on the traits of each team and game dynamics.. The New Orleans Saints have called the 3rd-most plays in the league since the start of last season, totaling a staggering 60.4 plays per game.. The passing attacks of both teams (including both volume and efficiency) ought to benefit from the calm "weather" conditions (i.e. zero wind) inside this dome, while ground volume may suffer.. Juwan Johnson checks in as one of the best TEs in the pass game since the start of last season, averaging an exceptional 44.0 adjusted yards per game while checking in at the 92nd percentile.
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Los Angeles Rams image thumbnail LA @ Denver Broncos image thumbnail DEN Sun, Sep 27 • 8:20 PM ET
Receiving Yards
Jaylen Waddle logo
Jaylen Waddle o58.5 Receiving Yards (-115)
Projection 69.73 (Over)
Best Odds
Pick made: an hour ago
EV Model Rating
Star rating: 5 out of 5
The projections expect the Denver Broncos to be the 4th-most pass-centric offense on the slate this week with a 62.2% pass rate, given their underlying traits and matchup dynamics.. Based on their underlying play style and game dynamics, the Broncos are expected by our trusted projection set to run 65.3 plays on offense in this contest: the 6th-most on the slate this week.. The Denver Broncos have called the 9th-most plays in the NFL since the start of last season, averaging a colossal 58.4 plays per game.. The Los Angeles Rams defense has been a glaring pass funnel since the start of last season, causing opposing quarterbacks to attempt the 6th-most passes in the league (34.2 per game) since the start of last season.. With a remarkable 51.0 adjusted yards per game through the air (87th percentile) since the start of last season, Jaylen Waddle stands as one of the best wide receivers in the game in the NFL.
Rushing Yards
Bo Nix logo
Bo Nix o15.5 Rushing Yards (-135)
Projection 18.4 (Over)
Best Odds
Pick made: an hour ago
EV Model Rating
Star rating: 4 out of 5
Based on their underlying play style and game dynamics, the Broncos are expected by our trusted projection set to run 65.3 plays on offense in this contest: the 6th-most on the slate this week.. The Denver Broncos have called the 9th-most plays in the NFL since the start of last season, averaging a colossal 58.4 plays per game.
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Philadelphia Eagles image thumbnail PHI @ Chicago Bears image thumbnail CHI Mon, Sep 28 • 8:15 PM ET
Anytime Touchdown
Jalen Hurts logo
Jalen Hurts Score a Touchdown (Yes: +150)
Projection 0.55 (Yes)
Best Odds
Pick made: an hour ago
EV Model Rating
Star rating: 4 out of 5
The Eagles have played in the most "bad weather" (rain, snow, or 15+ mph wind) games in the league since the start of last season, which ought to result in increased pass volume, reduced running volume, and improved passing offense performance when facing better weather in this game.. When talking about pass-blocking (and the positive effect it has on all pass attack stats), the O-line of the Eagles profiles as the 2nd-best in the NFL since the start of last season.. Jalen Hurts has been one of the leading TD throwers in the NFL since the start of last season, averaging a terrific 1.58 per game while grading out in the 85th percentile.. Opposing teams have completed passes at the 5th-highest clip in the league vs. the Bears defense since the start of last season (74.0% Adjusted Completion%).. The Chicago Bears defense has yielded the 5th-most TDs through the air in the league: 1.84 per game since the start of last season.
Anytime Touchdown
Colston Loveland logo
Colston Loveland Score a Touchdown (Yes: +375)
Projection 0.28 (Yes)
Best Odds
Pick made: an hour ago
EV Model Rating
Star rating: 4 out of 5
The Chicago Bears may pass less in this week's game (and call more rushes) given that they be rolling out backup QB Case Keenum.. This week's spread indicates a throwing game script for the Bears, who are -3-point underdogs.. With regard to a defense's effect on pace, at 27.49 seconds per play, our trusted projections expect the Chicago Bears to be the 4th-fastest in football (in a neutral context) at the moment.. The Chicago O-line ranks as the 6th-best in the league since the start of last season in protecting the passer, which has a positive influence on all passing game stats across the board.. The Philadelphia Eagles defensive tackles rank as the 2nd-best group of DTs in football since the start of last season in regard to defending the run.
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For every matchup in an NFL season, our NFL computer produces selections for a variety of different betting angles. Our computer picks are based on a proprietary algorithm that values each team in the current week to produce moneyline, spread, and point total selections.

The table above, below the game picks, tracks our NFL computer's results over the last 100 games, outlining the record and profit for selections, based on $100 unit size. We track the profit based on both opening and closing lines for every matchup.

How to Use NFL Computer Picks

The easiest way to utilize our computer picks is to simply follow our selections for every matchup, what you'd call ailing the computer." But there are other ways to utilize our NFL computer picks, as well.

You can use our NFL computer as a jumping-off point to do more research into specific lines, cross-referencing with expert picks, which can be found above the selections for some matchups, recent NFL betting trends, and more.

As well, you can gauge the confidence of the matchup. The larger the projected score, the more confident the computer is in a specific pick.

Or, if you want to implement a system, betting only on underdogs, for example, you can look for matchups in which our computer likes the underdog to inform which picks you're going to hone in on for a given week.

We have these computer picks for every sport you're looking to wager on, as well:

Free Computer Picks by Odds Shark

Moneyline

NFL moneyline picks are the simplest way to get in on the NFL action. All you have to do is simply bet on which team you think will win the game.

For moneyline picks, the favorite is represented with a minus sign (-) in front of the odds, while the underdog has a plus (+). However, you don't get the same profit for picking an underdog compared to a favorite. If the favored team is -120, a $100 bet on them would pay out $80 in profit and $180 total, if they win the game. The underdog winning at +150 would pay out a $150 profit, $250 total.

We have a complete breakdown of how to read NFL moneyline odds for these NFL computer picks.

Spread

While moneyline picks are the simplest, picking NFL games against the spread is probably the most common wager for regular NFL bettors.

To bet an NFL spread, you wager on whether a team will win by a certain number of points or more or if they'll lose by fewer points than the spread. For example, if the spread is -6.5 for the New England Patriots, you would win the bet if they win the game by 7 points or more. Or if a team is +6.5, you're betting on if they'll win outright or lose by fewer than 6.5 points.

There is a correlation between moneyline odds and the spread, as books set these lines based on the same information.

You can read more about NFL spreads here.

Totals (Over/Under)

If you aren’t entirely sold on which NFL team will win or cover in an NFL game, you can still use our NFL computer picks to bet on the point total.

As opposed to taking a side, in total or Over/Under betting, you wager on whether both NFL teams will combine for a final score of more than (Over) or less than (Under) the total number of points set by oddsmakers.

The computer picks, and your handicapping of totals is more about how you think both teams will score points, not which team has the edge to win.

More NFL Picks & Betting Tools

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NFL Free Picks FAQs

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