Premier League Tips, Predictions and Best Bets Matchday 21

March 6 can't get here quickly enough for English Premier League betting fans.

The next Manchester Derby is well over a month away, but there's a good chance both Manchester City and Manchester United will be at or near the top of the EPL standings as they rank 1-2 heading into Matchday 21.

City overtook United for top spot this past week with a 5-0 drubbing of West Brom, combined with United's stunning 2-1 home loss to last-place Sheffield. And Man City's surge has only galvanized its spot atop the EPL futures race, now listed at -350 to reclaim the Premier League crown.

Here are our top Premier League betting plays for Matchday 21:

Premier League Predictions for Matchday 21

Manchester City vs Sheffield United

Now that Man City have achieved their primary goal – surging into the top spot in the table despite a slow start – they'll now turn their focus to padding that lead in the coming weeks. And Saturday presents a great opportunity against a Sheffield United side that stunned Manchester's other club, but remain 20th in the standings with just two victories from their first 20 league matches.

And unlike some teams in the upper echelon of the Premier League, Man City have done an exemplary job of handling teams in the lower tier. The EPL leaders are a perfect 8-0 against clubs ranked 13th or lower in the current standings while outscoring them by a combined 23-1 tally. That's an average margin of victory just shy of three goals—making the -2 handicap a strong play here.

TIP: Manchester City -2 (+105)

Arsenal vs Manchester United

Dropping a 2-1 decision at Old Trafford to the Premier League bottom-feeders isn't exactly how Manchester United wanted to enter Saturday's pivotal showdown with Arsenal. That's especially problematic when you consider that the Gunners are one of the hottest teams going right now, having rolled to five victories and one draw over their previous six league fixtures.

Goal scoring has been a bit of an issue for United, who have struck just seven times in their last six Premier League matches. And with Arsenal having allowed just two goals through their last six league games, the task before the visitors is a tall one. Even though they look rejuvenated in 2020-21, we don't envision United scoring multiple times in this difficult away test.

TIP: Manchester United Under 1.5 (-163)

Chelsea vs Burnley

Chelsea are still singing the Blues, languishing in eighth place in the standings entering Sunday's meeting with a surprisingly spry Burnley club. The visitors have won back-to-back games to create some much-needed separation between themselves and the relegation zone—but they're still huge underdogs against a Chelsea side with just eight points from their last nine league games.

Current form is worth considering here if you're looking for an underdog play this weekend. Chelsea have scored just four goals from their last six league contests while Burnley held Liverpool off the scoresheet and limited Manchester United to just one goal in recent weeks. They might not pull out the win, but taking a victory or draw is an intriguing option at a nice price.

TIP: Burnley Win or Draw (+225)

Premier League Betting Card for Matchday 21

• Manchester City -2 (+105)
• Manchester United Under 1.5 (-163)
• Burnley Win or Draw (+225)

Where Can I Bet on Premier League Soccer?

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