Week 4 of the NFL season is upon us, and we've got our next international game on tap as the Minnesota Vikings play the Pittsburgh Steelers in Ireland.
That and a pair of Monday Night Football offerings line the schedule.
The headline game might be an AFC Championship preview as the Kansas City Chiefs host the Baltimore Ravens on Sunday afternoon, with Patrick Mahomes & Co. listed as home underdogs against Lamar Jackson's squad.
Here is a look at all of the Week 4 NFL odds.
Opening NFL odds for Week 4
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Seahawksvs  Cardinals |
Cardinals -1.5 | Seahawks -108 Cardinals -108 |
43.5 |
 Vikingsvs  Steelers |
Steelers +1.5 | Vikings -116 Steelers -102 |
40.5 |
 Titansvs  Texans |
Texans -7.5 | Titans +300 Texans -375 |
38.5 |
 Panthersvs  Patriots |
Patriots -4.5 | Panthers +180 Patriots -215 |
43.5 |
 Chargersvs  Giants |
Giants +5.5 | Chargers -255 Giants +210 |
45.5 |
 Saintsvs  Bills |
Bills -16.5 | Saints +1040 Bills -2000 |
48.5 |
 Eaglesvs  Buccaneers |
Buccaneers +3 | Eagles -158 Buccaneers +134 |
46.5 |
 Commandersvs  Falcons |
Falcons +3 | Commanders -158 Falcons +134 |
45.5 |
 Brownsvs  Lions |
Lions -8.5 | Browns +370 Lions -480 |
45.5 |
 Coltsvs  Rams |
Rams -3.5 | Colts +168 Rams -200 |
47.5 |
 Jaguarsvs  49ers |
49ers -3.5 | Jaguars +168 49ers -200 |
45.5 |
 Bearsvs  Raiders |
Raiders -1.5 | Bears -108 Raiders -108 |
47.5 |
 Ravensvs  Chiefs |
Chiefs +3 | Ravens -144 Chiefs +122 |
48.5 |
 Packersvs  Cowboys |
Cowboys +5.5 | Packers -270 Cowboys +220 |
48.5 |
 Jetsvs  Dolphins |
Dolphins -2.5 | Jets +132 Dolphins -156 |
43.5 |
 Bengalsvs  Broncos |
Broncos -7.5 | Bengals +300 Broncos -375 |
44.5 |
Lines as of 9-21
Seahawks vs Cardinals odds (Thursday, 8:15 p.m. ET, PRIME)
Opening line
- Cardinals -2.5
- Over/Under 43.5
- View full Seahawks vs. Cardinals odds and matchup
Opening line analysis coming soon!
Also see: full Thursday Night Football odds
Vikings vs Steelers odds (Sunday, 9:30 a.m. ET, NFL Network)
Opening line
- Steelers -2.5
- Over/Under 40.5
- View full Vikings vs. Steelers odds and matchup
Opening line analysis coming soon!
Titans vs Texans odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Texans -7.5
- Over/Under 39.5
- View full Titans vs. Texans odds and matchup
Opening line analysis coming soon!
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Panthers vs Patriots odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Patriots -5.5
- Over/Under 43.5
- View full Panthers vs. Patriots odds and matchup
Opening line analysis coming soon!
Chargers vs Giants odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Giants +5.5
- Over/Under 45.5
- View full Chargers vs. Giants odds and matchup
Opening line analysis coming soon!
Saints vs Bills odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Bills -14.5
- Over/Under 48.5
- View full Saints vs. Bills odds and matchup
Opening line analysis coming soon!
Covers NFL awards analysis
Eagles vs Buccaneers odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Buccaneers +3
- Over/Under 45.5
- View full Eagles vs. Buccaneers odds and matchup
Opening line analysis coming soon!
Commanders vs Falcons odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Falcons +1.5
- Over/Under 46.5
- View full Commanders vs. Falcons odds and matchup
Opening line analysis coming soon!
Browns vs Lions odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Lions -9.5
- Over/Under 46.5
- View full Browns vs. Lions odds and matchup
Opening line analysis coming soon!
More NFL betting analysis
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- Lamar Jackson’s record vs. every NFL team
Colts vs Rams odds (Sunday, 4:05 p.m. ET, FOX)
Opening line
- Rams -4.5
- Over/Under 46.5
- View full Colts vs. Rams odds and matchup
Opening line analysis coming soon!
Jaguars vs 49ers odds (Sunday, 4:05 p.m. ET, FOX)
Opening line
- 49ers -3
- Over/Under 44.5
- View full Jaguars vs. 49ers odds and matchup
Opening line analysis coming soon!
Bears vs Raiders odds (Sunday, 4:25 p.m. ET, CBS)
Opening line
- Raiders -2.5
- Over/Under 46.5
- View full Bears vs. Raiders odds and matchup
Opening line analysis coming soon!
Ravens vs Chiefs odds (Sunday, 4:25 p.m. ET, CBS)
Opening line
- Chiefs +2.5
- Over/Under 48.5
- View full Ravens vs. Chiefs odds and matchup
Opening line analysis coming soon!
Packers vs Cowboys odds (Sunday, 8:20 p.m. ET, NBC)
Opening line
- Cowboys +5.5
- Over/Under 48.5
- View full Packers vs. Cowboys odds and matchup
Opening line analysis coming soon!
Also see: full Sunday Night Football odds
Jets vs Dolphins odds (Monday, 7:15 p.m. ET, ESPN)
Opening line
- Dolphins -2.5
- Over/Under 43.5
- View full Jets vs. Dolphins odds and matchup
Opening line analysis coming soon!
Also see: full Monday Night Football odds
Bengals vs Broncos odds (Monday, 7:15 p.m. ET, ABC)
Opening line
- Broncos -6.5
- Over/Under 44.5
- View full Bengals vs. Broncos odds and matchup
Opening line analysis coming soon!
Also see: full Monday Night Football odds
Best NFL bets this week
Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!
Odds are correct at the time of publishing and are subject to change.
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