The New Orleans Saints head to Lumen Field on Sunday for a matchup with Sam Darnold and the Seattle Seahawks.
Jaxon Smith-Njigba has been balling out, and my Saints vs Seahawks predictions are eyeing him to do damage again on Sunday.
Read more for my NFL picks for Sunday, September 21.
Saints vs Seahawks prediction
Saints vs Seahawks Best bet: Jaxon Smith-Njigba Over 74.5 receiving yards (-114)
Despite the addition of Cooper Kupp, Jaxon Smith-Njigba went into the 2025 season as the Seattle Seahawks’ WR1, and he’s fully lived up to expectations through the first two weeks. The Ohio State product has already reeled in 17 catches for 227 yards.
Smith-Njigba has easily cashed the Over in both games, putting up over 100 yards receiving in each. He cooked the San Francisco 49ers for 124 yards in Week 1, and then put up another 103 yards receiving in a win over the Pittsburgh Steelers last Sunday.
The Saints’ secondary has looked respectable so far, but Smith-Njigba is a weapon, and he’s got major confidence at the moment. He’ll have another big game as Seattle looks to improve to 2-1.
Saints vs Seahawks same-game parlay
The Seahawks have lost three straight to the Saints, but their last meeting was in 2022. A lot has changed on both sides since then. Seattle just grabbed an impressive victory over the new-look Steelers, and they will be coming into this one with momentum.
Seattle covered the spread in Week 2, winning 31-17. New Orleans has shown a bit of promise with Spencer Rattler under center, but they’re clearly in a rebuild right now. Seattle shouldn’t have any issues winning by a touchdown, at the very least.
Sam Darnold’s start to his Seahawks career has been respectable, completing 67.9% of his throws for 445 yards and two touchdowns against two interceptions. He threw for 295 passing yards last weekend after just 150 yards through the air in Week 1.
Saints vs Seahawks SGP
- Jaxon Smith-Njigba Over 74.5 receiving yards
- Seahawks -7.5
- Sam Darnold Under 219.5 passing yards
Our big-ticket SGP: Olave Slowed!
Chris Olave has failed to clear his receiving yards total in both of the Saints' games, and meets a tough Seattle secondary that should hold him under the total again.
Saints vs Seahawks SGP
- Jaxon Smith-Njigba Over 74.5 receiving yards
- Seahawks -7.5
- Sam Darnold Under 219.5 passing yards
- Chris Olave Under 59.5 receiving yards
Saints vs Seahawks odds
- Spread: Saints +7.5 (-110) | Seahawks -7.5 (-110)
- Moneyline: Saints +280 | Seahawks -350
- Over/Under: Over 42.5 (-110) | Under 42.5 (-110)
More NFL picks and odds from Covers
Saints vs Seahawks trend to know
The New Orleans Saints have hit the Game Total Under in 11 of their last 20 games (+1.00 Units / 5% ROI). Find more NFL betting trends for Saints vs. Seahawks.
How to watch Saints vs Seahawks
| Location | Lumen Field, Seattle, WA |
| Date | Sunday, September 21, 2025 |
| Kickoff | 4:05 p.m. ET |
| TV | CBS |
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