The banged up Arizona Cardinals will try to break a four-game losing streak as they host the Green Bay Packers at State Farm Stadium on Sunday.
Green Bay is in great position to pick up its first road win of the year, and I’m taking it to cover in my Packers vs. Cardinals predictions below.
Read on for a full breakdown of this matchup in my free NFL picks for Sunday, October 19.
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Packers vs Cardinals prediction
Packers vs Cardinals Best bet: Packers -6.5 (-120 at FanDuel)
The Arizona Cardinals haven't won a game since a 27-22 win over the Carolina Panthers back on September 14, and though its four consecutive losses have all been close games, things aren’t looking up heading into Sunday’s game against the Packers.
The Cardinals don’t know who their quarterback will be this week, as Kyler Murray is still questionable with a foot injury, while Jacoby Brissett is coming off a solid performance in relief last week.
While the Green Bay Packers are 3-1-1 on the year, that might undersell how good they’ve looked overall. Green Bay had a few bad minutes against the Cleveland Browns which led to their only loss, and suffered a bizarre 40-40 tie on the road against the Dallas Cowboys.
But this is the same team that has a two-touchdown victory over the Detroit Lions. Along with continued improvement by Jordan Love at quarterback, the Packers have held every opponent except for Dallas to 18 points or less, while Arizona is only averaging 21.7 ppg.
The Cardinals have been keeping games close, but the Packers should be able to outgun them by enough to win by at least a touchdown.
I’m taking Green Bay to cover.
Packers vs Cardinals same-game parlay
The Packers are the clear favorite, as their defense should be able to shut down a Cardinals offense that’s averaging just 21.7 ppg and is dealing with a series of injuries.
Romeo Doubs is an excellent option as a TD scorer for our SGP, as opponents are throwing for 246 yards per game against Arizona.
Packers vs Cardinals SGP
- Packers -6.5
- Under 44.5
- Romeo Doubs anytime TD
Our big-ticket SGP: Doubs to Have a Day!
Doubs has gone for 55+ yards in each of his last two games, and is getting more looks than ever in the Green Bay offense over that span.
Packers vs Cardinals SGP
- Packers -6.5
- Under 44.5
- Romeo Doubs anytime TD
- Romeo Doubs Over 49.5 receiving yards
Packers vs Cardinals odds
- Spread: Packers -7 (-114) | Cardinals +7 (-106)
- Moneyline: Packers -390 | Cardinals +310
- Over/Under: Over 44.5 (-105) | Under 44.5 (-115)
More NFL picks and odds from Covers
Packers vs Cardinals trend to know
The Cardinals are 0-3 ATS at home this season. Find more NFL betting trends for Packers vs. Cardinals.
How to watch Packers vs Cardinals
Location | State Farm Stadium, Glendale, AZ |
Date | Sunday, October 19, 2025 |
Kickoff | 4:25 p.m. ET |
TV | FOX |
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