Packers vs Cardinals Predictions, Picks & Best Bets for NFL Week 7

With the Cardinals in disarray, backing the visiting Packers to cover isn’t much of a stretch.

Ed Scimia - Contributor at Covers.com
Ed Scimia • Betting Analyst
Oct 18, 2025 • 14:47 ET • 4 min read

NFL

Match starts: 15 hrs
ARI
39 %
GB
61 %
EXPERT PICK - SPREAD
Green Bay -6.5 (-120) Green Bay -6.5 (-120)
Read Analysis
Romeo Doubs Green Bay Packers NFL
Photo By - Imagn Images. Green Bay Packers wide receiver Romeo Doubs (87) celebrates in the end zone after he catches a pass for a touchdown.

The banged up Arizona Cardinals will try to break a four-game losing streak as they host the Green Bay Packers at State Farm Stadium on Sunday.

Green Bay is in great position to pick up its first road win of the year, and I’m taking it to cover in my Packers vs. Cardinals predictions below.

Read on for a full breakdown of this matchup in my free NFL picks for Sunday, October 19.

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Packers vs Cardinals prediction

Packers vs Cardinals Best bet: Packers -6.5 (-120 at FanDuel)

The Arizona Cardinals haven't won a game since a 27-22 win over the Carolina Panthers back on September 14, and though its four consecutive losses have all been close games, things aren’t looking up heading into Sunday’s game against the Packers.

The Cardinals don’t know who their quarterback will be this week, as Kyler Murray is still questionable with a foot injury, while Jacoby Brissett is coming off a solid performance in relief last week.

While the Green Bay Packers are 3-1-1 on the year, that might undersell how good they’ve looked overall. Green Bay had a few bad minutes against the Cleveland Browns which led to their only loss, and suffered a bizarre 40-40 tie on the road against the Dallas Cowboys.

But this is the same team that has a two-touchdown victory over the Detroit Lions. Along with continued improvement by Jordan Love at quarterback, the Packers have held every opponent except for Dallas to 18 points or less, while Arizona is only averaging 21.7 ppg.

The Cardinals have been keeping games close, but the Packers should be able to outgun them by enough to win by at least a touchdown.

I’m taking Green Bay to cover.

Packers vs Cardinals same-game parlay

The Packers are the clear favorite, as their defense should be able to shut down a Cardinals offense that’s averaging just 21.7 ppg and is dealing with a series of injuries.

Romeo Doubs is an excellent option as a TD scorer for our SGP, as opponents are throwing for 246 yards per game against Arizona.

Packers vs Cardinals SGP

  • Packers -6.5
  • Under 44.5
  • Romeo Doubs anytime TD

Our big-ticket SGP: Doubs to Have a Day!

Doubs has gone for 55+ yards in each of his last two games, and is getting more looks than ever in the Green Bay offense over that span.

Packers vs Cardinals SGP

  • Packers -6.5
  • Under 44.5
  • Romeo Doubs anytime TD
  • Romeo Doubs Over 49.5 receiving yards

Packers vs Cardinals odds

  • Spread: Packers -7 (-114) | Cardinals +7 (-106)
  • Moneyline: Packers -390 | Cardinals +310
  • Over/Under: Over 44.5 (-105) | Under 44.5 (-115)

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Packers vs Cardinals trend to know

The Cardinals are 0-3 ATS at home this season. Find more NFL betting trends for Packers vs. Cardinals.

How to watch Packers vs Cardinals

Location State Farm Stadium, Glendale, AZ
Date Sunday, October 19, 2025
Kickoff 4:25 p.m. ET
TV FOX

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Ed Scimia - Covers.com
Betting Analyst

Ed Scimia has been writing about the gaming industry for over 15 years. He graduated from Syracuse University with degrees in Magazine Journalism and Political Science in 2003, and has covered major gambling events like the World Series of Poker in his career. Since joining Covers in 2022, Ed has offered his sports betting analysis primarily on MLB, NFL, college football, and college basketball games, but is willing to take on any sport.

His betting strategy focuses more on finding line value based on deviations from the market rather than traditional handicapping, primarily shopping between DraftKings, FanDuel, and Fanatics in his home state of Connecticut, though he’s not afraid to do deep game analysis to find profitable bets at any book.

Outside of gambling, Ed is an avid curler who competes in mixed doubles on the World Curling Tour and runs a popular curling YouTube channel, Chess on Ice. That experience has come in handy during the Olympics, when he has proven to be a successful curling bettor as well. 

Ed's advice to new bettors is to always open multiple sportsbook accounts and check the odds at each before placing any bet. Successful sports betting is about consistently beating the closing line value, which requires finding spots where one book is offering odds far better than the rest of the market and jumping on those opportunities.

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