The Green Bay Packers came out of the bye week slowly, scoring just 10 points in the first half against the Bengals. However, they added 17 in the second half for a relatively comfortable 27-18 victory.
The Arizona Cardinals kept things close in yet another loss, and my early Packers vs. Cardinals predictions expect the birds to put up another strong fight in Week 7.
Here are my NFL picks for October 19.
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Packers vs Cardinals predictions
Here are our early thoughts on the spread and total for this week’s game. We will have a full game preview (with a best bet and SGP) later in the week.
Early Packers vs Cardinals spread pick: Cardinals +6.5
Some say that you create your own luck, but the Arizona Cardinals have been quite unlucky in recent weeks.
After starting the season 2-0, they've lost their last four games by a combined total of nine points. They were underdogs in three of those, including +10 in Indianapolis in Week 6.
Arizona led 17-14, 24-17, and 27-24 in the second half, but couldn't find the end zone again in the loss.
On the other side, the Green Bay Packers have not been overly impressive this season, especially on the road. They lost 22-10 in Philadelphia and 13-10 in Cleveland, then tied 40-40 in Dallas. They did win on Sunday by nine points, but failed to cover the 14-point spread against the woeful Bengals.
Arizona has enough firepower with GB and keep this game within a touchdown.
Early Packers vs Cardinals total pick: Over 44.5
This total opens a bit low at 43.5, given how these teams have played recently, especially Arizona.
The Cardinals have scored 20, 21, and 27 points in their last three games while allowing 23, 22, and 31. The Packers let the Bengals score 18 points on Sunday, so the Cards should be able to put up more than a few scores — and we know Green Bay can find the end zone.
This game may not go too far over 43.5 points, but both teams are capable of scoring 20 points and more, and neither defense inspires much confidence.
Packers vs Cardinals odds
- Packers vs. Cardinals spread: Cardinals +6.5
- Packers vs. Cardinals moneyline: Packers -310, Cardinals +250
- Packers vs. Cardinals Over/Under: 44.5
How to watch Packers vs Cardinals
- Packers vs. Cardinals matchup
- Date: Sunday, October 19, 2025, 4:25 p.m. ET
- City: Glendale, AZ
- Venue: State Farm Stadium
- TV: FOX
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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